Abstract
Although the benefits are sometimes obvious, traditional or herbal medicine is regarded with skepticism, because the mechanism through which plant compounds exert their powers are largely elusive. Recent studies have shown however that many of these plant compounds interact with specific ion channels and thereby modulate the sensing mechanism of the human body. Especially members of the Transient Receptor Potential (TRP) channels have drawn large attention lately as the receptors for plant-derived compounds such as capsaicin and menthol. TRP channels constitute a large and diverse family of channel proteins that can serve as versatile sensors that allow individual cells and entire organisms to detect changes in their environment. For this family, a striking number of empirical views have turned into mechanismbased actions of natural compounds. In this review we will give an overview of herbal compounds and toxins, which modulate TRP channels.
Current Neuropharmacology
Title: Herbal Compounds and Toxins Modulating TRP Channels
Volume: 6 Issue: 1
Author(s): Rudi Vennekens, Joris Vriens and Bernd Nilius
Affiliation:
Abstract: Although the benefits are sometimes obvious, traditional or herbal medicine is regarded with skepticism, because the mechanism through which plant compounds exert their powers are largely elusive. Recent studies have shown however that many of these plant compounds interact with specific ion channels and thereby modulate the sensing mechanism of the human body. Especially members of the Transient Receptor Potential (TRP) channels have drawn large attention lately as the receptors for plant-derived compounds such as capsaicin and menthol. TRP channels constitute a large and diverse family of channel proteins that can serve as versatile sensors that allow individual cells and entire organisms to detect changes in their environment. For this family, a striking number of empirical views have turned into mechanismbased actions of natural compounds. In this review we will give an overview of herbal compounds and toxins, which modulate TRP channels.
Export Options
About this article
Cite this article as:
Vennekens Rudi, Vriens Joris and Nilius Bernd, Herbal Compounds and Toxins Modulating TRP Channels, Current Neuropharmacology 2008; 6 (1) . https://dx.doi.org/10.2174/157015908783769644
DOI https://dx.doi.org/10.2174/157015908783769644 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
How Immune-inflammatory Processes Link CNS and Psychiatric Disorders: Classification and Treatment Implications
CNS & Neurological Disorders - Drug Targets Critical Steps in Tissue Processing in Histopathology
Recent Patents on DNA & Gene Sequences Osteopontin: An Effector and an Effect of Tumor Metastasis
Current Molecular Medicine Viral-Mediated Gene Transfer for Cancer Treatment
Current Pharmaceutical Biotechnology Evaluation of Pipemidic Acid Derivatives for Potential Antimicrobial Activity Application: <i>In silico</i> Studies on Bioactivity
Letters in Drug Design & Discovery Inhibiting the “Undruggable” RAS/Farnesyltransferase (FTase) Cancer Target by Manumycin-related Natural Products
Current Medicinal Chemistry The Pro-Survival Function of Akt Kinase can be Overridden or Altered to Contribute to Induction of Apoptosis
Current Cancer Drug Targets Effects of PPARγ Ligands on Vascular Tone
Current Molecular Pharmacology The miRNAs and Epithelial-Mesenchymal Transition in Cancers
Current Pharmaceutical Design Synthesis and Biological Evaluation of Macamides Derivatives as Potent Inhibitors of Breast Cancer Cell MCF-7
Letters in Drug Design & Discovery Glucuronides in Anti-Cancer Therapy
Current Medicinal Chemistry - Anti-Cancer Agents Recent Advances in the Development of Multi-Kinase Inhibitors
Mini-Reviews in Medicinal Chemistry LncRNA as a Therapeutic Target for Angiogenesis
Current Topics in Medicinal Chemistry Tumor-Targeting Peptides and Small Molecules as Anti-Cancer Agents to Overcome Drug Resistance
Current Medicinal Chemistry Cystatin C: An Emerging Biomarker in Cardiovascular Disease
Current Topics in Medicinal Chemistry Chemopreventive Agents Alters Global Gene Expression Pattern: Predicting their Mode of Action and Targets
Current Cancer Drug Targets Study of Parasitic Infections, Cancer, and other Diseases with Mass-Spectrometry and Quantitative Proteome-Disease Relationships
Current Proteomics EDITORIAL (Thematic Issue: Brain Gut Axis-New View)
Current Neuropharmacology The Global Component-Target Network in Panax Ginseng C
Letters in Drug Design & Discovery Estrogen Receptor Ligands for Targeting Breast Tumours: A Brief Outlook on Radioiodination Strategies
Current Radiopharmaceuticals