Abstract
Non-alcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance, and its prevalence is rising in parallel with worldwide increases in obesity and type 2 diabetes. However, the nature of this relationship remains debatable. In particular, it is unclear whether insulin resistance causes NAFLD or hepatic steatosis per se reduces insulin sensitivity. This review will examine data from recent studies on the link between insulin resistance and NAFLD, focusing on studies that have attempted to dissociate fatty liver and hepatic insulin resistance.
Keywords: Non-alcoholic fatty liver disease, Insulin resistance, Triglycerides, Free fatty acids, Steatosis, Mitochondrial dysfunction, Hepatic Fat, Hepatic Steatosis, Pathogenesis, Fat Accumulation, hyperinsulinemia, Lipid Dynamics, Intracellular Signaling, Hepatic Insulin Resistance, methionine and choline deficiency (MCD), very low density lipoprotein (VLDL), insulin receptor substrate (IRS), nuclear factor-kappaB (NFκB)
Current Diabetes Reviews
Title: Interrelationships between Hepatic Fat and Insulin Resistance in Non- Alcoholic Fatty Liver Disease
Volume: 6 Issue: 5
Author(s): Khalida A. Lockman and Moffat J. Nyirenda
Affiliation:
Keywords: Non-alcoholic fatty liver disease, Insulin resistance, Triglycerides, Free fatty acids, Steatosis, Mitochondrial dysfunction, Hepatic Fat, Hepatic Steatosis, Pathogenesis, Fat Accumulation, hyperinsulinemia, Lipid Dynamics, Intracellular Signaling, Hepatic Insulin Resistance, methionine and choline deficiency (MCD), very low density lipoprotein (VLDL), insulin receptor substrate (IRS), nuclear factor-kappaB (NFκB)
Abstract: Non-alcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance, and its prevalence is rising in parallel with worldwide increases in obesity and type 2 diabetes. However, the nature of this relationship remains debatable. In particular, it is unclear whether insulin resistance causes NAFLD or hepatic steatosis per se reduces insulin sensitivity. This review will examine data from recent studies on the link between insulin resistance and NAFLD, focusing on studies that have attempted to dissociate fatty liver and hepatic insulin resistance.
Export Options
About this article
Cite this article as:
A. Lockman Khalida and J. Nyirenda Moffat, Interrelationships between Hepatic Fat and Insulin Resistance in Non- Alcoholic Fatty Liver Disease, Current Diabetes Reviews 2010; 6 (5) . https://dx.doi.org/10.2174/157339910793360879
DOI https://dx.doi.org/10.2174/157339910793360879 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Royal Jelly Acid, 10-Hydroxy-trans-2-Decenoic Acid, as a Modulator of the Innate Immune Responses
Endocrine, Metabolic & Immune Disorders - Drug Targets Chemical and Clinical Development of Darinaparsin, a Novel Organic Arsenic Derivative
Anti-Cancer Agents in Medicinal Chemistry Are the Antioxidant Properties of Carvedilol Important for the Protection of Cardiac Mitochondria?
Current Vascular Pharmacology 13-lncRNAs Signature to Improve Diagnostic and Prognostic Prediction of Hepatocellular Carcinoma
Combinatorial Chemistry & High Throughput Screening Insights into the Biological Evaluation of Pterocarpanquinones and Carbapterocarpans with Anti-tumor Activity against MDR Leukemias
Anti-Cancer Agents in Medicinal Chemistry Role of Human and Mouse HspB1 in Metastasis
Current Molecular Medicine “Antisurvival” Factor Treatment for Hormone Refractory Prostate Cancer: Secondary Hormonal Ablation Using Somatostatin Analogs
Current Cancer Therapy Reviews Regulation of EMT by KLF4 in Gastrointestinal Cancer
Current Cancer Drug Targets New Developments in Systemic Therapy for Hepatocellular Carcinoma
Current Cancer Therapy Reviews CDK-associated Cullin 1 Promotes Cell Proliferation and Inhibits Cell Apoptosis in Human Glioblastoma
Current Cancer Drug Targets Expression of Plasma hsa-miR122 in HBV-Related Hepatocellular Carcinoma (HCC) in Vietnamese Patients
MicroRNA Invasive Aspergillosis in Children and Adolescents
Current Pharmaceutical Design Recent Advances in Optical Molecular Imaging and its Applications in Targeted Drug Delivery
Current Drug Targets Liver Stem Cells: From Preface to Advancements
Current Stem Cell Research & Therapy Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of PDGFRA, PDGFRB or FGFR1
Current Cancer Therapy Reviews Membrane Transporters as Determinants of the Pharmacology of Platinum Anticancer Drugs
Current Cancer Drug Targets Insect Peptides – Perspectives in Human Diseases Treatment
Current Medicinal Chemistry Interaction and Reaction of the Antioxidant Mn<sup>III</sup> [Meso-Tetrakis(4-NMethyI Pyridinium) Porphyrin] with the Apoptosis Reporter Lipid Phosphatidylserine
Current Physical Chemistry Innate Immunity and the Heart
Current Pharmaceutical Design Tyrosine Kinase Inhibitor-Induced Hypertension: Role of Hypertension as a Biomarker in Cancer Treatment
Current Vascular Pharmacology