Abstract
Calcium channels significantly contribute to many cellular processes, including such critical ones as proliferation, differentiation, and apoptosis. In prostate cancer, the influence of calcium channels has been known for over 30 years, with the first observations that calcium channel blockers affect the progression of cancer towards more aggressive phase. Later research identified additional classes of channel proteins having an important regulatory role and affecting malignant transformation. This review discusses the accumulated scientific knowledge focused on calcium channel involvement in regulation of cell fate in prostate tissues as well as recent developments in patents targeted at prostate cancer treatments and involving calcium channel modulators.
Keywords: Apoptosis, calcium channels, cell fate, patent, proliferation, prostate cancer
Recent Patents on Anti-Cancer Drug Discovery
Title:Calcium Channels and Prostate Cancer
Volume: 8 Issue: 1
Author(s): George Shapovalov, Roman Skryma and Natalia Prevarskaya
Affiliation:
Keywords: Apoptosis, calcium channels, cell fate, patent, proliferation, prostate cancer
Abstract: Calcium channels significantly contribute to many cellular processes, including such critical ones as proliferation, differentiation, and apoptosis. In prostate cancer, the influence of calcium channels has been known for over 30 years, with the first observations that calcium channel blockers affect the progression of cancer towards more aggressive phase. Later research identified additional classes of channel proteins having an important regulatory role and affecting malignant transformation. This review discusses the accumulated scientific knowledge focused on calcium channel involvement in regulation of cell fate in prostate tissues as well as recent developments in patents targeted at prostate cancer treatments and involving calcium channel modulators.
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Shapovalov George, Skryma Roman and Prevarskaya Natalia, Calcium Channels and Prostate Cancer, Recent Patents on Anti-Cancer Drug Discovery 2013; 8 (1) . https://dx.doi.org/10.2174/1574892811308010018
DOI https://dx.doi.org/10.2174/1574892811308010018 |
Print ISSN 1574-8928 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3970 |
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