Abstract
Cancer is the second leading cause of death worldwide. There is greater need for more effective and less toxic therapeutic and preventive strategies. Natural products are becoming an important research area for novel and bioactive molecules for drug discovery. Phytochemicals and dietary compounds have been used for the treatment of cancer throughout history due to their safety, low toxicity, and general availability. Many active phytochemicals are in human clinical trials. Studies have indicated that daily consumption of dietary phytochemicals have cancer protective effects against carcinogens. They can inhibit, delay, or reverse carcinogenesis by inducing detoxifying and antioxidant enzymes systems, regulating inflammatory and proliferative signaling pathways, and inducing cell cycle arrest and apoptosis. Epidemiological studies have also revealed that high dietary intakes of fruits and vegetables reduce the risk of cancer. This review discusses potential natural cancer preventive compounds, their molecular targets, and their mechanisms of actions.
Keywords: Chemoprevention, Phytochemicals, Activator protein-1, Nuclear factor (NF)-κB, Cyclooxygenase (COX)-2, Apoptosis, Cell cycle arrest, Angiogenesis, Oxidative stress, Curcumin, (-)-epigallocatechin-3-gallate, Resveratrol, Isothyocynates
Anti-Cancer Agents in Medicinal Chemistry
Title:Cancer Prevention with Promising Natural Products: Mechanisms of Action and Molecular Targets
Volume: 12 Issue: 10
Author(s): Poyil Pratheeshkumar, Chakkenchath Sreekala, Zhuo Zhang, Amit Budhraja, Songze Ding, Young-Ok Son, Xin Wang, Andrew Hitron, Kim Hyun-Jung, Lei Wang, Jeong-Chae Lee and Xianglin Shi
Affiliation:
Keywords: Chemoprevention, Phytochemicals, Activator protein-1, Nuclear factor (NF)-κB, Cyclooxygenase (COX)-2, Apoptosis, Cell cycle arrest, Angiogenesis, Oxidative stress, Curcumin, (-)-epigallocatechin-3-gallate, Resveratrol, Isothyocynates
Abstract: Cancer is the second leading cause of death worldwide. There is greater need for more effective and less toxic therapeutic and preventive strategies. Natural products are becoming an important research area for novel and bioactive molecules for drug discovery. Phytochemicals and dietary compounds have been used for the treatment of cancer throughout history due to their safety, low toxicity, and general availability. Many active phytochemicals are in human clinical trials. Studies have indicated that daily consumption of dietary phytochemicals have cancer protective effects against carcinogens. They can inhibit, delay, or reverse carcinogenesis by inducing detoxifying and antioxidant enzymes systems, regulating inflammatory and proliferative signaling pathways, and inducing cell cycle arrest and apoptosis. Epidemiological studies have also revealed that high dietary intakes of fruits and vegetables reduce the risk of cancer. This review discusses potential natural cancer preventive compounds, their molecular targets, and their mechanisms of actions.
Export Options
About this article
Cite this article as:
Pratheeshkumar Poyil, Sreekala Chakkenchath, Zhang Zhuo, Budhraja Amit, Ding Songze, Son Young-Ok, Wang Xin, Hitron Andrew, Hyun-Jung Kim, Wang Lei, Lee Jeong-Chae and Shi Xianglin, Cancer Prevention with Promising Natural Products: Mechanisms of Action and Molecular Targets, Anti-Cancer Agents in Medicinal Chemistry 2012; 12 (10) . https://dx.doi.org/10.2174/187152012803833035
DOI https://dx.doi.org/10.2174/187152012803833035 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
Call for Papers in Thematic Issues
Induction of cell death in cancer cells by modulating telomerase activity using small molecule drugs
Telomeres are distinctive but short stretches present at the corners of chromosomes and aid in stabilizing chromosomal makeup. Resynthesis of telomeres supported by the activity of reverse transcriptase ribonucleoprotein complex telomerase. There is no any telomerase activity in human somatic cells, but the stem cells and germ cells undergone telomerase ...read more
Signaling and enzymatic modulators in cancer treatment
Cancer accounts for nearly 10 million deaths in 2022 and is considered the leading cause of worldwide mortality. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy, radiotherapy and surgery are the most important approach for the treatment of several ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Antimalarial Drugs and their Useful Therapeutic Lives: Rational Drug Design Lessons from Pleiotropic Action of Quinolines and Artemisinins
Current Drug Discovery Technologies Atheroma Burden and Morphology in Women
Current Pharmaceutical Design Targeting the Toll-System in Cardiovascular Sciences
Recent Patents on Inflammation & Allergy Drug Discovery Challenges and Perspectives of Antiplatelet Therapy in Patients with Diabetes Mellitus and Coronary Artery Disease
Current Pharmaceutical Design Patent Selections:
Recent Patents on Anti-Cancer Drug Discovery Peri-Procedural Care of Renal Nerve Ablation Candidates
Current Clinical Pharmacology Menopause, A Universal Female Experience: Lessons from Mexico and Central America
Current Women`s Health Reviews Effects of Medroxyprogesterone Acetate on the Risk of Cardiovascular Disease in Postmenopausal Women Receiving Estrogen
Vascular Disease Prevention (Discontinued) Antioxidants Suppress Th1-Type Immune Response In Vitro
Drug Metabolism Letters Intravascular Targeting of a New Anticoagulant Heparin Compound
Cardiovascular & Hematological Disorders-Drug Targets Should Percutaneous Coronary Intervention be the Standard Treatment Strategy for Significant Coronary Artery Disease in all Octogenarians?
Current Cardiology Reviews GLP-1, Incretin Mimetics and DPP 4 Inhibitors: New Ways in the Treatment of Type 2 Diabetes
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Immunomodulatory Activity of Garlic
Current Immunology Reviews (Discontinued) Statins and Metabolism of High Density Lipoprotein
Cardiovascular & Hematological Agents in Medicinal Chemistry The Metabolic Syndrome and Chronic Liver Disease
Current Pharmaceutical Design Metabolic Syndrome: Sex-Related Cardiovascular Risk and Therapeutic Approach
Current Medicinal Chemistry Ezetimibe Therapy for Dyslipidemia: An Update
Current Pharmaceutical Design Biomarkers in Post-stroke Depression
Current Neurovascular Research Hypolipidemic, Antioxidant and Cardioprotective Effects of the Aqueous Extract from <i>Scorzanera Undulata</i> Tubers in Streptozotocin-Induced Diabetic Rats
Cardiovascular & Hematological Agents in Medicinal Chemistry Marine Collagen as a Source of Bioactive Molecules: A Review
The Natural Products Journal