Abstract
Coronary heart disease is the leading cause of mortality worldwide, affecting millions of men and women every year. Elucidation of key signaling factors and their pathways are critical for understanding and developing novel therapeutic targets for protection of the myocardium from ischemia. EGR-1, an immediate early gene and a zinc finger transcription factor plays critical role in various cardiovascular patho-biological processes. This article reviews the growing evidence implicating EGR-1 pathway in myocardial ischemia/reperfusion, cardiac hypertrophy and other cardiovascular complications like atherosclerosis.
Keywords: Atherosclerosis, EGR-1, ischemia/reperfusion injury, myocardial cell death, myocardial infarction, oxidative stress, vascular inflammation.
Cardiovascular & Hematological Agents in Medicinal Chemistry
Title:Early Growth Response-1 (EGR-1) – A Key player in Myocardial Cell Injury
Volume: 12 Issue: 2
Author(s): Nirupama Ramadas, Barathi Rajaraman, Ashok A. Kuppuswamy and Srinivasan Vedantham
Affiliation:
Keywords: Atherosclerosis, EGR-1, ischemia/reperfusion injury, myocardial cell death, myocardial infarction, oxidative stress, vascular inflammation.
Abstract: Coronary heart disease is the leading cause of mortality worldwide, affecting millions of men and women every year. Elucidation of key signaling factors and their pathways are critical for understanding and developing novel therapeutic targets for protection of the myocardium from ischemia. EGR-1, an immediate early gene and a zinc finger transcription factor plays critical role in various cardiovascular patho-biological processes. This article reviews the growing evidence implicating EGR-1 pathway in myocardial ischemia/reperfusion, cardiac hypertrophy and other cardiovascular complications like atherosclerosis.
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Cite this article as:
Ramadas Nirupama, Rajaraman Barathi, Kuppuswamy A. Ashok and Vedantham Srinivasan, Early Growth Response-1 (EGR-1) – A Key player in Myocardial Cell Injury, Cardiovascular & Hematological Agents in Medicinal Chemistry 2014; 12 (2) . https://dx.doi.org/10.2174/1871525713666150123152131
DOI https://dx.doi.org/10.2174/1871525713666150123152131 |
Print ISSN 1871-5257 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6182 |
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