Abstract
CD4+ T-cells are central players orchestrating antigen-specific immunity and tolerance. Importantly, dendritic cells (DCs) are responsible for priming T-cells and for promoting their differentiation from naïve T-cells into appropriate functional cells. Because of their fundamental roles in controlling immunity, activation and differentiation of DCs and CD4+ T-cells require tight regulatory mechanisms. Several studies have shown that dopamine, not only mediates interactions into the nervous system, but it can also contribute to the modulation of immunity. Here, we review the emerging role of this neurotransmitter as a regulator of DCs and CD4+ T-cells physiology and its consequent involvement, in the regulation of immune response. We specially focus the analysis in the role of dopamine receptor D5 expressed on DCs and CD4+ T-cells in the modulation of immunity. We also discuss how alterations in the dopamine-mediated regulation of immunity could contribute to the onset and development of immune-related disorders.
Keywords: CD4+ helper T-cells, dendritic cells, dopamine, regulatory T-cells, T-cell mediated immunity.
Endocrine, Metabolic & Immune Disorders - Drug Targets
Title:Modulation of T-cell Mediated Immunity by Dopamine Receptor D5
Volume: 13 Issue: 2
Author(s): Carolina Prado, Sebastian Bernales and Rodrigo Pacheco
Affiliation:
Keywords: CD4+ helper T-cells, dendritic cells, dopamine, regulatory T-cells, T-cell mediated immunity.
Abstract: CD4+ T-cells are central players orchestrating antigen-specific immunity and tolerance. Importantly, dendritic cells (DCs) are responsible for priming T-cells and for promoting their differentiation from naïve T-cells into appropriate functional cells. Because of their fundamental roles in controlling immunity, activation and differentiation of DCs and CD4+ T-cells require tight regulatory mechanisms. Several studies have shown that dopamine, not only mediates interactions into the nervous system, but it can also contribute to the modulation of immunity. Here, we review the emerging role of this neurotransmitter as a regulator of DCs and CD4+ T-cells physiology and its consequent involvement, in the regulation of immune response. We specially focus the analysis in the role of dopamine receptor D5 expressed on DCs and CD4+ T-cells in the modulation of immunity. We also discuss how alterations in the dopamine-mediated regulation of immunity could contribute to the onset and development of immune-related disorders.
Export Options
About this article
Cite this article as:
Prado Carolina, Bernales Sebastian and Pacheco Rodrigo, Modulation of T-cell Mediated Immunity by Dopamine Receptor D5, Endocrine, Metabolic & Immune Disorders - Drug Targets 2013; 13 (2) . https://dx.doi.org/10.2174/1871530311313020007
DOI https://dx.doi.org/10.2174/1871530311313020007 |
Print ISSN 1871-5303 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3873 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Recent Research Progress in Natural Bioactive Constituents against Lipid Metabolic Diseases
Current Topics in Medicinal Chemistry Preliminary Studies on Ligand-based Design and Evaluation of New Mycobacterial ATP Synthase Inhibitors
Current Drug Therapy Microenvironmental Interactions in Chronic Lymphocytic Leukemia: Hints for Pathogenesis and Identification of Targets for Rational Therapy
Current Pharmaceutical Design The Neuropathology of Vascular Disease in the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS)
Current Alzheimer Research The Brain, the Penis and Steroid Hormones: Clinical Correlates with Endothelial Dysfunction
Current Pharmaceutical Design The Role of the Osteoprotegerin/RANKL/RANK System in Diabetic Vascular Disease
Current Medicinal Chemistry Oxidative Stress, Endothelial Function and Angiogenesis Induced by Cell Therapy and Gene Therapy
Current Pharmaceutical Biotechnology Significance of Green Synthetic Chemistry from a Pharmaceutical Perspective
Current Pharmaceutical Design The Complexity of Aging: Cancer Risk Among Elderly People and Infectious Risk Among Those with Cancer
Anti-Cancer Agents in Medicinal Chemistry Possible Therapeutic Uses of Extracellular Vesicles for Reversion of Activated Hepatic Stellate Cells: Context and Future Perspectives
Current Molecular Medicine The Effects of Direct Renin Inhibitor, Aliskiren, on Arterial Hypertension, Chronic Kidney Disease and Cardiovascular Disease: Optimal Pharmacotherapy
Cardiovascular & Hematological Agents in Medicinal Chemistry Determinants of Longevity: Genetics, Biomarkers and Therapeutic Approaches
Current Pharmaceutical Design QSAR, Docking and Molecular Fragment Replacement Study based on a Conformation- Independent Approach on Trifluorophenyl β-aminoamide derivatives as DPP IV Inhibitors
Current Enzyme Inhibition Evaluation of Temporal Changes in Urine-based Metabolomic and Kidney Injury Markers to Detect Compound Induced Acute Kidney Tubular Toxicity in Beagle Dogs
Current Topics in Medicinal Chemistry Mechanisms of CTLA-4-Ig in Tolerance Induction
Current Pharmaceutical Design Clinical Utility of Acarbose, an α-Glucosidase Inhibitor in Cardiometabolic Disorders
Current Drug Metabolism Speciation of Metal Complexes of Medicinal Interest: Relationship between Solution Equilibria and Pharmaceutical Properties
Current Medicinal Chemistry The Neuropsychological Hypothesis of Antidepressant Drug Action Revisited
CNS & Neurological Disorders - Drug Targets Cell Signaling Mechanisms by which Geniposide Regulates Insulin- Degrading Enzyme Expression in Primary Cortical Neurons
CNS & Neurological Disorders - Drug Targets The Place of Somatostatin Analogs in the Diagnosis and Treatment of the Neuoroendocrine Glands Tumors
Recent Patents on Anti-Cancer Drug Discovery