Abstract
Mitochondria are ubiquitous organelles in eukaryotic cells whose primary function is to generate energy supplies in the form of ATP through oxidative phosphorylation. As the entry point for most electrons into the respiratory chain, NADH:ubiquinone oxidoreductase, or complex I, is the largest and least understood component of the mitochondrial oxidative phosphorylation system. Substantial progress has been made in recent years in understanding its subunit composition, its assembly, the interaction among complex I and other respiratory components, and its role in oxidative stress and apoptosis. This review provides an updated overview of the structure of complex I, as well as its cellular functions, and discusses the implication of complex I dysfunction in various human diseases.
Keywords: Mitochondria, complex I, oxidative stress, reactive oxygen species, apoptosis, complex I functions
Current Medicinal Chemistry
Title: Mitochondrial Respiratory Complex I: Structure, Function and Implication in Human Diseases
Volume: 16 Issue: 10
Author(s): Lokendra K. Sharma, Jianxin Lu and Yidong Bai
Affiliation:
Keywords: Mitochondria, complex I, oxidative stress, reactive oxygen species, apoptosis, complex I functions
Abstract: Mitochondria are ubiquitous organelles in eukaryotic cells whose primary function is to generate energy supplies in the form of ATP through oxidative phosphorylation. As the entry point for most electrons into the respiratory chain, NADH:ubiquinone oxidoreductase, or complex I, is the largest and least understood component of the mitochondrial oxidative phosphorylation system. Substantial progress has been made in recent years in understanding its subunit composition, its assembly, the interaction among complex I and other respiratory components, and its role in oxidative stress and apoptosis. This review provides an updated overview of the structure of complex I, as well as its cellular functions, and discusses the implication of complex I dysfunction in various human diseases.
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Cite this article as:
Sharma K. Lokendra, Lu Jianxin and Bai Yidong, Mitochondrial Respiratory Complex I: Structure, Function and Implication in Human Diseases, Current Medicinal Chemistry 2009; 16 (10) . https://dx.doi.org/10.2174/092986709787846578
DOI https://dx.doi.org/10.2174/092986709787846578 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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