Abstract
ATP binding cassette transporters are implicated in multidrug resistant phenotypes of tumor cells and may be cancer stem cell markers. Inhibitors of drug efflux pumps represent an emerging group of potentially useful agents for the improvement of antitumor therapy. Here we provide an overview of drug transporter functions and modulation.
Keywords: ATP binding cassette transporters, antitumor drugs, modulators
Mini-Reviews in Medicinal Chemistry
Title: ABC Transporters as Potential Targets for Modulation of Drug Resistance
Volume: 9 Issue: 9
Author(s): L. Gatti, G. L. Beretta, G. Cossa, F. Zunino and P. Perego
Affiliation:
Keywords: ATP binding cassette transporters, antitumor drugs, modulators
Abstract: ATP binding cassette transporters are implicated in multidrug resistant phenotypes of tumor cells and may be cancer stem cell markers. Inhibitors of drug efflux pumps represent an emerging group of potentially useful agents for the improvement of antitumor therapy. Here we provide an overview of drug transporter functions and modulation.
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Gatti L., Beretta L. G., Cossa G., Zunino F. and Perego P., ABC Transporters as Potential Targets for Modulation of Drug Resistance, Mini-Reviews in Medicinal Chemistry 2009; 9 (9) . https://dx.doi.org/10.2174/138955709788922656
DOI https://dx.doi.org/10.2174/138955709788922656 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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