Abstract
Survival of myocytes and mesenchymal cells in the heart is tightly regulated by a number of adaptive processes that are invoked with the changes that occur within the parenchyma and stroma. Autophagy is implicated in cellular housekeeping duties and maintenance of the integrity of the intracellular milieu by removal of protein aggregates and damaged organelles, whereas under pathophysiological conditions, the chronic up-regulation of autophagy may lead to significant disturbance of homeostatic conditions. Nonetheless, the role of autophagy in heart disease in the context of cardiac ischemia-reperfusion injury is currently unclear. This review will focus upon the role of autophagy as it pertains to ischemiareperfusion damage in the heart.
Keywords: Autophagy, heart, heart disease, ischemia-reperfusion, mitophagy.
Current Molecular Medicine
Title:Autophagy and Heart Disease: Implications for Cardiac Ischemia- Reperfusion Damage
Volume: 14 Issue: 5
Author(s): S. Ghavami, S. Gupta, E. Ambrose, M. Hnatowich, D.H. Freed and I.M.C. Dixon
Affiliation:
Keywords: Autophagy, heart, heart disease, ischemia-reperfusion, mitophagy.
Abstract: Survival of myocytes and mesenchymal cells in the heart is tightly regulated by a number of adaptive processes that are invoked with the changes that occur within the parenchyma and stroma. Autophagy is implicated in cellular housekeeping duties and maintenance of the integrity of the intracellular milieu by removal of protein aggregates and damaged organelles, whereas under pathophysiological conditions, the chronic up-regulation of autophagy may lead to significant disturbance of homeostatic conditions. Nonetheless, the role of autophagy in heart disease in the context of cardiac ischemia-reperfusion injury is currently unclear. This review will focus upon the role of autophagy as it pertains to ischemiareperfusion damage in the heart.
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Cite this article as:
Ghavami S., Gupta S., Ambrose E., Hnatowich M., Freed D.H. and Dixon I.M.C., Autophagy and Heart Disease: Implications for Cardiac Ischemia- Reperfusion Damage, Current Molecular Medicine 2014; 14 (5) . https://dx.doi.org/10.2174/1566524014666140603101520
DOI https://dx.doi.org/10.2174/1566524014666140603101520 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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