Computational Studies of 1-Hydrazinophthalazine (Hydralazine) as Antineoplasic Agent. Docking Studies on Methyltransferase

Title: Computational Studies of 1-Hydrazinophthalazine (Hydralazine) as Antineoplasic Agent. Docking Studies on Methyltransferase

Volume: 2 Issue: 4

Author(s): Enrique Angeles, Victor HugoVazquez-Valadez, Oscar Vazquez-Valadez, Ana Maria Velazquez-Sanchez, Alberto Ramirez, Luisa Martinez, Sandra Diaz-Barriga, Andres Romero-Rojas, Gustavo Cabrera, Rafael Lopez-Castanares and Alfonso Duenas-Gonzalez

Affiliation:

Keywords: docking, hydralazine, dna methyltransferase, dna methylation inhibitor, tumor suppressor gene

Abstract: Hydralazine is a drug used as anti-hypertensive, and recently reported to be a DNA methylation inhibitor able to demethylate and reactivate the expression of tumor suppressor genes in cancer. The aim of the present study was to explore the potential mechanism by which hydralazine inhibits DNA methylation. For this purpose, we assessed the structural and electronic properties between 1-hydrazinophthalazine (hydralazine) and a putative ligand methyltransferase.

Cite this article as:

Angeles Enrique, HugoVazquez-Valadez Victor, Vazquez-Valadez Oscar, Velazquez-Sanchez Maria Ana, Ramirez Alberto, Martinez Luisa, Diaz-Barriga Sandra, Romero-Rojas Andres, Cabrera Gustavo, Lopez-Castanares Rafael and Duenas-Gonzalez Alfonso, Computational Studies of 1-Hydrazinophthalazine (Hydralazine) as Antineoplasic Agent. Docking Studies on Methyltransferase, Letters in Drug Design & Discovery 2005; 2 (4) . https://dx.doi.org/10.2174/1570180054038413