Abstract
As therapeutic options and supportive care for the treatment of neoplastic disease have improved, there has been an associated increase in the incidence of leptomeningeal disease. In this review, the clinical presentation, natural history, diagnostic evaluation, and treatment options for this often devastating sequela of solid tumors, lymphoma, and leukemia will be summarized. The therapeutic efficacy of ionizing radiation, systemic agents, and intrathecal drugs will be examined from the existing literature. Additionally the pathophysiology, which in part defines the therapeutic limitations in approaching this patient population, will be discussed in order to assist in individualized clinical decision making.
Keywords: Leptomeningeal metastasis, carcinomatous meningitis, treatment, diagnosis
Current Cancer Therapy Reviews
Title: Leptomeningeal Metastasis: Challenges in Diagnosis and Treatment
Volume: 7 Issue: 4
Author(s): Ticiana Leal, Julie E. Chang, Minesh Mehta and H. Ian Robins
Affiliation:
Keywords: Leptomeningeal metastasis, carcinomatous meningitis, treatment, diagnosis
Abstract: As therapeutic options and supportive care for the treatment of neoplastic disease have improved, there has been an associated increase in the incidence of leptomeningeal disease. In this review, the clinical presentation, natural history, diagnostic evaluation, and treatment options for this often devastating sequela of solid tumors, lymphoma, and leukemia will be summarized. The therapeutic efficacy of ionizing radiation, systemic agents, and intrathecal drugs will be examined from the existing literature. Additionally the pathophysiology, which in part defines the therapeutic limitations in approaching this patient population, will be discussed in order to assist in individualized clinical decision making.
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Cite this article as:
Leal Ticiana, E. Chang Julie, Mehta Minesh and Ian Robins H., Leptomeningeal Metastasis: Challenges in Diagnosis and Treatment, Current Cancer Therapy Reviews 2011; 7 (4) . https://dx.doi.org/10.2174/157339411797642597
DOI https://dx.doi.org/10.2174/157339411797642597 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
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argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
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