Abstract
Obesity and type 2 diabetes continue to be major public health burdens with type 2 diabetes rising in epidemic proportions. Since known risk factors do not explain all of the variance in the population, it is important to identify novel risk factors that can lead to development of new preventive measures. Chronic psychological stress and depression are associated with type 2 diabetes but the mechanism remains unclear. Neuroendocrine changes induced by these stressors, specifically activation of the hypothalamic-pituitaryadrenal (HPA) axis and sympathetic nervous system (SNS), might provide a unifying explanation. The objectives of this review are (1) to summarize the metabolic impact of HPA axis and SNS dysfunction induced by depression and stress, (2) to summarize the relation of neuroendocrine parameters to risk factors for diabetes, (3) to discuss the limitations of assessing neuroendocrine function in populationbased and intervention studies, and (4) to summarize the evidence of the impact of stress reduction, by cognitive behavior therapy (CBT), on neuroendocrine factors and on outcomes in diabetes and obesity.
Keywords: pseudo-Cushing syndromes, Sympathetic nervous system, Cortisol Response, Major Depressive Disorder, Cognitive behavior therapy
Current Diabetes Reviews
Title: A Review of the Evidence for a Neuroendocrine Link Between Stress, Depression and Diabetes Mellitus
Volume: 3 Issue: 4
Author(s): Sherita Hill Golden
Affiliation:
Keywords: pseudo-Cushing syndromes, Sympathetic nervous system, Cortisol Response, Major Depressive Disorder, Cognitive behavior therapy
Abstract: Obesity and type 2 diabetes continue to be major public health burdens with type 2 diabetes rising in epidemic proportions. Since known risk factors do not explain all of the variance in the population, it is important to identify novel risk factors that can lead to development of new preventive measures. Chronic psychological stress and depression are associated with type 2 diabetes but the mechanism remains unclear. Neuroendocrine changes induced by these stressors, specifically activation of the hypothalamic-pituitaryadrenal (HPA) axis and sympathetic nervous system (SNS), might provide a unifying explanation. The objectives of this review are (1) to summarize the metabolic impact of HPA axis and SNS dysfunction induced by depression and stress, (2) to summarize the relation of neuroendocrine parameters to risk factors for diabetes, (3) to discuss the limitations of assessing neuroendocrine function in populationbased and intervention studies, and (4) to summarize the evidence of the impact of stress reduction, by cognitive behavior therapy (CBT), on neuroendocrine factors and on outcomes in diabetes and obesity.
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Cite this article as:
Golden Hill Sherita, A Review of the Evidence for a Neuroendocrine Link Between Stress, Depression and Diabetes Mellitus, Current Diabetes Reviews 2007; 3 (4) . https://dx.doi.org/10.2174/157339907782330021
DOI https://dx.doi.org/10.2174/157339907782330021 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
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