Abstract
Allergic bronchopulmonary aspergillosis (ABPA) is a frequent syndrome in patients with cystic fibrosis (CF) or asthma. Animal models revealed distinct roles for the chemokines CCL2, CCL3, CCL5, CCL6, CCL17 and CCL22 and their receptors in the pathogenesis of allergic aspergillosis. In humans, serum levels of the CCR4 ligand CCL17 identified ABPA in patients with CF or asthma, suggesting CCL17 as novel diagnostic marker and future therapeutical target in ABPA. This review illustrates the manifold role of chemokines in animal models of allergic aspergillosis and translates these findings to human lung diseases.
Keywords: ABPA, allergic aspergillosis, chemokines, CCL17, TARC, CCR4, cystic fibrosis, asthma
Inflammation & Allergy - Drug Targets (Discontinued)
Title: Chemokines in Allergic Aspergillosis - From Animal Models to Human Lung Diseases
Volume: 5 Issue: 4
Author(s): Dominik Hartl, Karen F. Buckland and Cory M. Hogaboam
Affiliation:
Keywords: ABPA, allergic aspergillosis, chemokines, CCL17, TARC, CCR4, cystic fibrosis, asthma
Abstract: Allergic bronchopulmonary aspergillosis (ABPA) is a frequent syndrome in patients with cystic fibrosis (CF) or asthma. Animal models revealed distinct roles for the chemokines CCL2, CCL3, CCL5, CCL6, CCL17 and CCL22 and their receptors in the pathogenesis of allergic aspergillosis. In humans, serum levels of the CCR4 ligand CCL17 identified ABPA in patients with CF or asthma, suggesting CCL17 as novel diagnostic marker and future therapeutical target in ABPA. This review illustrates the manifold role of chemokines in animal models of allergic aspergillosis and translates these findings to human lung diseases.
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Cite this article as:
Hartl Dominik, Buckland F. Karen and Hogaboam M. Cory, Chemokines in Allergic Aspergillosis - From Animal Models to Human Lung Diseases, Inflammation & Allergy - Drug Targets (Discontinued) 2006; 5 (4) . https://dx.doi.org/10.2174/187152806779010972
DOI https://dx.doi.org/10.2174/187152806779010972 |
Print ISSN 1871-5281 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4055 |
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