Abstract
Obesity and type 2 diabetes (T2D) are global problems affecting all age groups and have been characterized as lifestyle disorders. Though no study has clearly proved a direct correlation between obesity and T2D, a number of factors are associated with obesity causing insulin resistance and T2D. The factors such as adipokines and various transcription factors help to maintain a proper metabolic state in the body. Deregulation in any of these signalling balances due to obesity may trigger an inflammatory cascade which could lead to the aforesaid problems of insulin resistance and T2D. In this review, we have discussed the factors that probably link inflammation to obesity-induced insulin resistance and subsequently T2D and the possible therapeutic opportunities to decrease health risk of T2D in future.
Keywords: Inflammation, adipokines, signal transduction, macrophages/adipocytes, obesity, type-2 diabetes, angiotensinogen, adiponectin, sterol regulatory element binding protein-1, triacylglycerol, thiazolidinedione, monocyte chemotactic protein-1
Endocrine, Metabolic & Immune Disorders - Drug Targets
Title: The Evil Axis of Obesity, Inflammation and Type-2 Diabetes
Volume: 11 Issue: 1
Author(s): Arghya Das and Sangita Mukhopadhyay
Affiliation:
Keywords: Inflammation, adipokines, signal transduction, macrophages/adipocytes, obesity, type-2 diabetes, angiotensinogen, adiponectin, sterol regulatory element binding protein-1, triacylglycerol, thiazolidinedione, monocyte chemotactic protein-1
Abstract: Obesity and type 2 diabetes (T2D) are global problems affecting all age groups and have been characterized as lifestyle disorders. Though no study has clearly proved a direct correlation between obesity and T2D, a number of factors are associated with obesity causing insulin resistance and T2D. The factors such as adipokines and various transcription factors help to maintain a proper metabolic state in the body. Deregulation in any of these signalling balances due to obesity may trigger an inflammatory cascade which could lead to the aforesaid problems of insulin resistance and T2D. In this review, we have discussed the factors that probably link inflammation to obesity-induced insulin resistance and subsequently T2D and the possible therapeutic opportunities to decrease health risk of T2D in future.
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Cite this article as:
Das Arghya and Mukhopadhyay Sangita, The Evil Axis of Obesity, Inflammation and Type-2 Diabetes, Endocrine, Metabolic & Immune Disorders - Drug Targets 2011; 11 (1) . https://dx.doi.org/10.2174/187153011794982086
DOI https://dx.doi.org/10.2174/187153011794982086 |
Print ISSN 1871-5303 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3873 |
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