Abstract
SUMMARY
Objective: To test the reliability, clinical and psychometric validity of the Brain Symptom and Impact Questionnaire (BASIQ) in patients with brain metastases. Methods: Brain metastases patients were interviewed using the BASIQ, Functional Assessment of Cancer-Brain (FACT-Br) and FACT-General (FACT-G) at baseline, with a follow-up assessment at 1 month. Results: Forty patients had complete one data and the median age was 64 years. Patients with higher KPS, ECOG of 2, primary breast cancer, or >3 brain metastases, scored higher on the symptom scale of the BASIQ. All subscales showed no significant change in patient symptoms from baseline to follow-up. Conclusion: This study supports that the reliability, clinical and psychometric validity of BASIQ to be used in brain metastases patients.
Papers of special note have been highlighted as: • of interest; •• of considerable interest
References
- 1 Molecular MRI enables early and sensitive detection of brain metastases. Proc. Natl Acad. Sci. USA 109(17), 6674–6679 (2012).
- 2 Quality of life in patients with brain metastases treated with a palliative course of whole-brain radiotherapy. J. Palliat. Med. 10(2), 367–374 (2007).
- 3 . Modern multidisciplinary management of brain metastases. Curr. Oncol. Rep. 12(1), 34–40 (2010).• Comprehensive review of current treatment options available for patients with brain metastases.
- 4 . Multidisciplinary management of brain metastases. Oncologist 12(7), 884–898 (2007).
- 5 A pilot study of neurocognitive function in patients with one to three new brain metastases initially treated with stereotactic radiosurgery alone. Neurosurgery 60(2), 277–283 (2007).
- 6 . Management of central nervous system metastases. Semin. Oncol. (1), 81–91 (1977).
- 7 . Whole brain radiotherapy for the treatment of multiple brain metastases. Cochrane Database Syst. Rev. (3), CD003869 (2006).
- 8 . Quality of life in oncology trials: a clinical guide. Semin. Radiat. Oncol. 13(3), 235–247 (2003).
- 9 Quality of life in patients with brain metastases using the EORTC QLQ-BN20+2 and QLQ-C15-PAL. Int. J. Radiat. Oncol. Biol. Phys. 83(4), 1238–1245 (2012).
- 10 Content validation of the FACT-Br with patients and health-care professionals to assess quality of life in patients with brain metastases. J. Radiat. Oncol. 3(1), 105–113 (2012).•• Study of similar nature to the present study, which validated the use of the FACT-Br in patients with brain metastases.
- 11 Brain metastasis from an unknown primary, or primary brain tumour? A diagnostic dilemma. Curr. Oncol. 16(1), 62–66 (2009).
- 12 EORTC QLQ-C15-PAL quality of life scores in patients with advanced cancer referred for palliative radiotherapy. Support. Care Cancer 20(4), 841–848 (2012).
- 13 Content validation of the brain symptom and impact questionnaire (BASIQ) in patients and health-care professionals to assess quality of life in patients with brain metastases. Support. Care Cancer. 21(Suppl. 1), S132 (2013).•• First phase of the present study, which involved the content validation for the Brain Metastases Symptom and Impact Questionnaire (BASIQ) questionnaire.
- 14 . Developing criteria for establishing interrater reliability of specific items: applications to assessment of adaptive behavior. Am. J. Ment. Defic. 86(2), 127–137 (1981).
- 15 . Psychometric Theory (3rd Edition). Mc Graw-Hill, NY, USA (1994).
- 16 Development of the European Organisation for Research and Treatment of Cancer quality of life questionnaire module for older people with cancer: the EORTC QLQ-ELD15. Eur. J. Cancer. 46(12), 2242–2252 (2010).
- 17 Symptoms and quality of life in cancer patients with brain metastases following palliative radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 75(4), 1125–1131 (2009).• Examines quality of life and symptoms in patients with brain metastases follow palliative radiotherapy, which is a similar patient population to the present study.
- 18 . Relationship between neurocognitive function and quality of life after whole-brain radiotherapy in patients with brain metastasis. Int. J. Radiat. Oncol. Biol. Phys. 71(1), 64–70 (2008).
- 19 . Karnofsky performance status scale. Spec. Care Dentist. 29(4), 147–148 (2009).
- 20 . Dexamethasone treatment in patients with brain metastases and primary brain tumors: do the benefits outweigh the side-effects? Support. Care Cancer. 10(4), 322–328 (2002).
- 21 Symptom response after palliative radiotherapy for patients with brain metastases. Eur. J. Cancer. 38(4), 487–496 (2002).