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Therapeutic nanoparticles in clinics and under clinical evaluation

    Catherine A Schütz

    Institut Universitaire de Pathologie/CHUV/UNIL, Rue du Bugnon 25, 1011 Lausanne, Switzerland

    ,
    Lucienne Juillerat-Jeanneret

    * Author for correspondence

    Institut Universitaire de Pathologie/CHUV/UNIL, Rue du Bugnon 25, 1011 Lausanne, Switzerland. .

    ,
    Heinz Mueller

    Swiss Federal Institute of Intellectual Property, Patent Department, Stauffacherstrasse 65/59g, 3003 Bern, Switzerland

    ,
    Iseult Lynch

    Centre for BioNano Interactions; School of Chemistry & Chemical Biology, University College Dublin, Dublin, Ireland

    &
    Michael Riediker

    Institute for Work & Health, Rue du Bugnon 21, 1011 Lausanne, Switzerland

    Published Online:https://doi.org/10.2217/nnm.13.8

    This article reviews nanoparticulate–chemotherapeutic systems that have been developed for human therapy, considering the components of the nanoparticles, the therapeutic agents associated with the nanoparticles and the clinical indications these therapeutic nanoparticles have been developed for. In this evaluation we have put into perspective the types of nanomaterials and their therapeutic indications. We have reviewed the nanoparticulate–chemotherapeutic systems that have been published, approved and marketed and that are currently in clinical use. We have also analyzed the nanoparticulate–chemotherapeutic systems that are in clinical trials and under preclinical development.

    Papers of special note have been highlighted as: ▪ of interest ▪▪ of considerable interest

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