Comparison of the Accumulation Kinetics of L-(Methyl-¹¹C)-Methionine and D-(Methyl-¹¹ C)-Methionine in Brain Tumors Studied with Positron Emission Tomography

Mats Bergström the Departments of Neuroradiology, Neurophysiology, Neurosurgery, Radiation physics and Karolinska Pharmacy, Karolinska Sjukhuset, Stockholm; the Departments of Diagnostic Radiology, Physical Biology, Gustaf Werner Institute, Uppsala; the Department of Organic Chemistry, Uppsala University, Uppsala, Sweden

H. Lundqvist the Departments of Neuroradiology, Neurophysiology, Neurosurgery, Radiation physics and Karolinska Pharmacy, Karolinska Sjukhuset, Stockholm; the Departments of Diagnostic Radiology, Physical Biology, Gustaf Werner Institute, Uppsala; the Department of Organic Chemistry, Uppsala University, Uppsala, Sweden

K. Ericson the Departments of Neuroradiology, Neurophysiology, Neurosurgery, Radiation physics and Karolinska Pharmacy, Karolinska Sjukhuset, Stockholm; the Departments of Diagnostic Radiology, Physical Biology, Gustaf Werner Institute, Uppsala; the Department of Organic Chemistry, Uppsala University, Uppsala, Sweden

A. Lilja the Departments of Neuroradiology, Neurophysiology, Neurosurgery, Radiation physics and Karolinska Pharmacy, Karolinska Sjukhuset, Stockholm; the Departments of Diagnostic Radiology, Physical Biology, Gustaf Werner Institute, Uppsala; the Department of Organic Chemistry, Uppsala University, Uppsala, Sweden

P. Johnström the Departments of Neuroradiology, Neurophysiology, Neurosurgery, Radiation physics and Karolinska Pharmacy, Karolinska Sjukhuset, Stockholm; the Departments of Diagnostic Radiology, Physical Biology, Gustaf Werner Institute, Uppsala; the Department of Organic Chemistry, Uppsala University, Uppsala, Sweden

B. Långström the Departments of Neuroradiology, Neurophysiology, Neurosurgery, Radiation physics and Karolinska Pharmacy, Karolinska Sjukhuset, Stockholm; the Departments of Diagnostic Radiology, Physical Biology, Gustaf Werner Institute, Uppsala; the Department of Organic Chemistry, Uppsala University, Uppsala, Sweden

H. von Holst the Departments of Neuroradiology, Neurophysiology, Neurosurgery, Radiation physics and Karolinska Pharmacy, Karolinska Sjukhuset, Stockholm; the Departments of Diagnostic Radiology, Physical Biology, Gustaf Werner Institute, Uppsala; the Department of Organic Chemistry, Uppsala University, Uppsala, Sweden

L. Eriksson the Departments of Neuroradiology, Neurophysiology, Neurosurgery, Radiation physics and Karolinska Pharmacy, Karolinska Sjukhuset, Stockholm; the Departments of Diagnostic Radiology, Physical Biology, Gustaf Werner Institute, Uppsala; the Department of Organic Chemistry, Uppsala University, Uppsala, Sweden

G. Blomqvist the Departments of Neuroradiology, Neurophysiology, Neurosurgery, Radiation physics and Karolinska Pharmacy, Karolinska Sjukhuset, Stockholm; the Departments of Diagnostic Radiology, Physical Biology, Gustaf Werner Institute, Uppsala; the Department of Organic Chemistry, Uppsala University, Uppsala, Sweden

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Abstract

Five patients with glioma were examined with positron emission tomography after the administration of ¹¹C-L-methionine and at a following day with ¹¹C-D-methionine. The rates of accumulation of the tracers were determined in the tumor and in the normal brain tissue according to a graphical technique of Patlak et coll. (24). The accumulation rates for L-methionine were on the average 2.4 times higher than those of D-methionine in the tumors. The corresponding ratio for normal brain tissue was 2.3. It is concluded that in this group of tumors without obvious blood-tumor-barrier breakdown, a stereospecific process with similar properties as in the normal brain tissue, is responsible for the accumulation of the labelled methionine.

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Comparison of the Accumulation Kinetics of L-(Methyl-¹¹C)-Methionine and D-(Methyl-¹¹ C)-Methionine in Brain Tumors Studied with Positron Emission Tomography

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Comparison of the Accumulation Kinetics of L-(Methyl-¹¹C)-Methionine and D-(Methyl-¹¹ C)-Methionine in Brain Tumors Studied with Positron Emission Tomography