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Effectiveness of Strontium Ranelate in the Treatment of Rat Model of Legg–Calve–Perthes Disease

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Abstract

Background

Legg–Calve–Perthes disease (LCPD) causes osteonecrosis of the femoral head (ONFH) by temporarily interrupting the blood supply in children. Even with potential toward bone regeneration and revascularization in LCPD, the prognosis depends on the deformity of femoral heads, and successful rate with the current treatments varies. Antiresorptive therapy such as bisphosphonate, which maintains mechanical stability of the femoral head by inhibiting necrotic bone resorption, has proven effective in animal models. However, concerns on simultaneous decline in bone turnover rate still leave room for improvement. Strontium ranelate with dual effect on inhibiting bone resorption and accelerating bone formation is presumed to be an ideal therapy for reserving sphericity of femoral heads in LCPD

Materials and Methods

In this study of a rat model of ONFH, randomized groups of rats treated with strontium ranelate or normal saline are compared at different time points in analysis of radiological, histological, and bone morphometric changes. Gait analysis was also compared between the two groups

Results

The group treated with strontium ranelate recovered their normal gait earlier than the control group did. Bone density, trabecular thickness, sphericity of the femoral head, and bone regeneration potential were also preserved in the strontium ranelate group

Conclusion

Strontium ranelate effectively prevented collapse of the ischemic femoral head and enhanced trabecular thickness in the rat model of LCPD. Hopefully, this preclinical experiment can improve the effectiveness of strontium ranelate treatment for pediatric ONFH

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Authors and Affiliations

  1. Graduate School of Biotechnology and Bioengineering, Yuan Ze University, Taoyuan, Taiwan

    Wei-Chuan Chen

  2. Department of Orthopaedic Surgery, Taipei Medical University Hospital, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taoyuan, 11031, Taiwan

    Amyla Tan &  Chih-Hwa Chen

  3. Bone and Joint Research Center, Department of Orthopedics and Traumatology, Taipei Medical University Hospital, School of Medicine, College of Medicine, Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan

    Chih-Hwa Chen

  4. Department of Orthopaedic surgery, Wan Fang Hospital, School of Medicine, College of Medicine, Taipei Medical University, Taoyuan, Taiwan

    Yu-Pin Chen, Wei-Pin Ho & Tai-Yuan Chuang

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  1. Yu-Pin Chen
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  2. Amyla Tan
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  3. Wei-Pin Ho
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Correspondence to Chih-Hwa Chen.

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Chen, YP., Tan, A., Ho, WP. et al. Effectiveness of Strontium Ranelate in the Treatment of Rat Model of Legg–Calve–Perthes Disease. IJOO 52, 380–386 (2018). https://doi.org/10.4103/ortho.IJOrtho_437_16

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  • DOI: https://doi.org/10.4103/ortho.IJOrtho_437_16

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