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    Korean J Urol. 2008 Oct;49(10):917-922. Korean.
    Published online Oct 31, 2008.
    https://doi.org/10.4111/kju.2008.49.10.917
    Copyright © 2008 The Korean Urological Association
    Original Article

    Treatment of Simple Renal Cysts by Percutaneous Aspiration and OK-432 Sclerotherapy

    Sung Jin Park, Won Sik Ham, Won Tae Kim, Dong Hoon Lee, Soung Yong Cho,1 Kang Su Cho and Young Deuk Choi
      • Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
      • 1Department of Urology, Inje University College of Medicine, Ilsan, Korea.
    Received March 14, 2008; Accepted August 25, 2008.

    Abstract

    Purpose

    Percutaneous aspiration with sclerotherapy has been widely used for the treatment of symptomatic or large simple renal cysts. Ethanol has been most commonly used as a sclerosing agent; however, a temporary percutaneous nephrostomy for multiple ethanol injections is necessary to achieve a low recurrence rate. Thus, we used OK-432 as a new sclerosing agent without a temporary percutaneous nephrostomy for multiple injections, and also compared our results with the results of previous studies.

    Materials and Methods

    Between October 2005 and April 2006, 50 patients (63 simple renal cysts) who underwent percutaneous OK-432 sclerotherapy for simple renal cysts were evaluated. The simple renal cysts were aspirated under ultrasonography and fluoroscopy, after which OK-432 was injected into the cyst. Follow-up was performed with ultrasonography or CT scan after 3 months. Regression of the renal cyst or a >70% reduction in size with no symptoms was considered a treatment success.

    Results

    Among 63 renal cysts in 50 patients, complete regression occurred in 17 (27.0%). Greater than a 90% reduction in size occurred in 8 (12.7%), a 80-90% reduction in size occurred in 21 (33.3%), and a 70-80% reduction in size occurred in 15 (23.8%); a <70% reduction in size occurred in 2 (3%). The overall efficacies of success were 96.8%. After the procedure, there were only some minor complications, such as mild fever, local pain, and liver function test elevation that subsided with symptomatic treatment.

    Conclusions

    Percutaneous OK-432 sclerotherapy is simple, safe, and effective and can be an alternative first-line therapy of simple renal cysts.

    Keywords
    Renal cyst; OK-432; Sclerotherapy

    Figures

    Fig. 1
    (A) Bilateral simple renal cysts on the lower pole of the right kidney (3.8cm) and the upper pole of the left kidney (6.0cm) in a CT coronal view. (B) Collapsed previous renal cyst after bilateral OK-432 (Picibanil®) sclerosing therapy in a CT coronal view.

    Tables

    Table 1
    Characteristics of patients and cysts

    Table 2
    Characteristics of treatment and follow-up

    Table 3
    Reported success rates following single sclerotherapy vs. serial sclerotherapies

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