Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016, 160(3):417-422 | DOI: 10.5507/bp.2016.027

The incidence of MYB gene breaks in adenoid cystic carcinoma of the salivary glands and its prognostic significance

Martin Broza, Petr Steinerb, Richard Salzmana, Lukas Hauerc, Ivo Stareka
a Department of Otorhinolaryngology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic
b Bioptic Laboratory Ltd, Molecular Pathology Laboratory, Pilsen and Department of Pathology, Faculty of Medicine in Plzen, Charles University in Prague, Pilsen, Czech Republic
c Department of Maxillofacial Surgery, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic

Aims: To detect MYB gene breaks in adenoid cystic carcinoma (ACC) of the salivary glands and its correlation with prognosis and selected clinical parameters



Methods: MYB gene break was detected by FISH assay in 23 adenoid cystic carcinomas using formalin-fixed paraffin-embedded blocks. The Kaplan-Meier survival analysis was used to estimate prognosis.

Results: Fifteen of 23 evaluated tumours were MYB positive and 8 MYB negative. The 10-year cumulative survival, respectively disease free interval, was 60.0%, respectively 59.3%, in MYB positive patients and 88.5%, respectively 80.0%, in MYB negative patients (long rank test, P=0.23). There were no significant differences in age, gender, perineural invasion, the presence of hematogenic or nodal metastases or degree of histopathological grading between MYB positive and MYB negative patients.

Conclusion: A tendency to differences in the survival of patients with ACC, depending on their MYB status. MYB negative patients were predisposed to better prognosis.

Keywords: adenoid cystic carcinoma, MYB gene, salivary gland, prognosis

Received: November 27, 2015; Accepted: April 27, 2016; Prepublished online: May 12, 2016; Published: September 20, 2016  Show citation

ACS AIP APA ASA Harvard Chicago IEEE ISO690 MLA NLM Turabian Vancouver
Broz, M., Steiner, P., Salzman, R., Hauer, L., & Starek, I. (2016). The incidence of MYB gene breaks in adenoid cystic carcinoma of the salivary glands and its prognostic significance. Biomedical papers, 160(3), 417-422. doi: 10.5507/bp.2016.027
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Vander Poorten VL, Balm AJ, Hilgers FJ, Tan IB, Loftus Coll BM, Keus RB, Hart AA. The development of a prognostic score for patients with parotid carcinoma. Cancer 1999;85(9):2057-67. Go to original source... Go to PubMed...
    2. Milano A, Longo,F, Basile M, Iaffaioli RV, Caponigro, F. Recent advances in the treatment of salivary gland cancers: emphasis on molecular targeted therapy. Oral oncology 2007;43(8):729-34. Go to original source... Go to PubMed...
    3. Gondivkar SM, Gadbail AR, Chole R, Parikh RV. Adenoid cystic carcinoma: a rare clinical entity and literature review. Oral oncol 2011;47(4):231-6. Go to original source... Go to PubMed...
    4. Speight PM, & Barrett AW. Salivary gland tumours. Oral diseases 2002;8(5):229-40. Go to original source... Go to PubMed...
    5. Szanto PA, Luna MA, Tortoledo ME, White RA. Histologic grading of adenoid cystic carcinoma of the salivary glands. Cancer 1984;54(6):1062-9. Go to original source... Go to PubMed...
    6. Spiro RH, Huvos AG. Stage means more than grade in adenoid cystic carcinoma. Am J Surg 1992;164(6):623-8. Go to original source... Go to PubMed...
    7. Seethala R.R. An update on grading of salivary gland carcinomas. Head Neck Pathol 2009;3(1):69-77. Go to original source... Go to PubMed...
    8. Seethala RR, Hunt JL, Baloch ZW, LiVolsi VA, Barnes EL. Adenoid cystic carcinoma with high-grade transformation: a report of 11 cases and a review of the literature. Am J Surg Pathol 2007;31(11):1683-94. Go to original source... Go to PubMed...
    9. Weinreb I. Translocation-associated salivary gland tumours: a review and update. Adv Anat Pathol 2013;20(6):367-77. Go to original source... Go to PubMed...
    10. Geurts JM, Schoenmakers EF, Röijer E, Aström AK, Stenman G, van de Ven WJ. Identification of NFIB as recurrent translocation partner gene of HMGIC in pleomorphic adenomas. Oncogene 1998;16(7):865-72. Go to original source... Go to PubMed...
    11. Behboudi A, Enlund F, Winnes, Nordkvist A, Leivo I, Flaberg E, Szekely L, Mäkitie A, Grenman R, Mark J, Stenman G. Molecular classification of mucoepidermoid carcinomas-Prognostic significance of the fusion oncogene. Genes Chromosomes Cancer 2006;45(5):470-81. Go to original source... Go to PubMed...
    12. Hellquist H, Skalova A. Histopathology of the salivary glands. In: miscellaneous. Springer 2014; p 430-431. Go to original source...
    13. Skálová A, Vanecek T, Sima R, Laco J, Weinreb I, Perez-Ordonez B, Michal, M. Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumour entity. Am J Surg Pathol 2010;34(5):599-608. Go to original source... Go to PubMed...
    14. Antonescu CR, Zhang L, Chang NE, Pawel BR, Travis W, Katabi N, Fletcher CD. EWSR1-POU5F1 fusion in soft tissue myoepithelial tumours. A molecular analysis of sixty-six cases, including soft tissue, bone, and visceral lesions, showing common involvement of the EWSR1 gene. Genes Chromosomes Cancer 2010;49(12):1114-24. Go to original source... Go to PubMed...
    15. Sasahira T, Kurihara M, Yamamoto K, Bhawal UK, Kirita T,Kuniyasu H. Downregulation of runt-related transcription factor 3 associated with poor prognosis of adenoid cystic and mucoepidermoid carcinomas of the salivary gland. Cancer Sci 2011;102(2):492-7. Go to original source... Go to PubMed...
    16. He JF, Ge MH., Zhu X., Chen C, Tan, Z, Li YN, Gu ZY. Expression of RUNX3 in salivary adenoid cystic carcinoma: implications for tumour progression and prognosis. Cancer Sci 2008; 99(7):1334-40. Go to original source... Go to PubMed...
    17. Stárek I, Kučerová L, Skálová A, Brož M, Bakaj T, Langová K. Imunohistochemická exprese C-kit onkoproteinu u karcinomů slinných žláz (pilotní studie). Otorinolaryngologie a foniatrie 2010;(3):129-35.
    18. Stárek I, Kučerová L, Skálová A, Brož M, Bakaj T, Zapletalová A, Hostička L. Imunohistochemická exprese onkoproteinu EGFR a její prognostický význam u karcinomů slinných žláz. Otorinolaryngologie a foniatrie 2011;2:78-84.
    19. Lee SK, Kwon MS, Lee YS, Choi, SH, Kim, SY, Cho KJ, Nam, SY. Prognostic value of expression of molecular markers in adenoid cystic cancer of the salivary glands compared with lymph node metastasis: a retrospective study. World J Surg Oncol 2012;10:266. Go to original source... Go to PubMed...
    20. Pattabiraman DR, Gonda TJ. Role and potential for therapeutic targeting of MYB in leukemia. Leukemia 2013;27(2):269-77. Go to original source... Go to PubMed...
    21. Clappier E, Cuccuini W, Kalota A, Crinquette A, Cayuela JM, Dik WA, Soulier J. The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children. Blood 2007;110(4):1251-61. Go to original source... Go to PubMed...
    22. Bell D, Roberts D, Karpowicz M, Hanna EY, Weber RS, El-Naggar AK. Clinical significance of Myb protein and downstream target genes in salivary adenoid cystic carcinoma. Cancer Biol Ther 2011;12(7):569-73. Go to original source... Go to PubMed...
    23. West RB, Kong C, Clarke N, Gilks T, Lipsick J, Cao H, Le,QT. MYB expression and translocation in adenoid cystic carcinomas and other salivary gland tumours with clinicopathologic correlation. Am J Surg Pathol 2011;35(1):92. Go to original source... Go to PubMed...
    24. MitaniY, Li J, Rao PH, ZhaoYJ, Bell D, Lippman SM, El-Naggar AK. Comprehensive analysis of the MYB-NFIB gene fusion in salivary adenoid cystic carcinoma: Incidence, variability, and clinicopathologic significance. Clin Cancer Res 2010;16(19):4722-31. Go to original source... Go to PubMed...
    25. Mitani Y, Rao PH, Futreal PA, Roberts DB, Stephens PJ, Zhao YJ, El-Naggar AK. Novel chromosomal rearrangements and break points at the t (6; 9) in salivary adenoid cystic carcinoma: association with MYB-NFIB chimeric fusion, MYB expression, and clinical outcome. Clin Cancer Res 2011;17(22):7003-14. Go to original source... Go to PubMed...
    26. Persson M, Andrén Y, Mark J, Horlings, HM, Persson F, Stenman,G. Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck. Proceedings of the National Academy of Sciences 2009;106(44):18740-4. Go to original source... Go to PubMed...
    27. Moskaluk CA. Adenoid cystic carcinoma: clinical and molecular features. Head Neck Pathol 2013;7(1):17-22. Go to original source... Go to PubMed...
    28. Brill LB, Kanner WA, Fehr A, Andrén Y, Moskaluk, CA, Löning, T, Frierson HF. Analysis of MYB expression and MYB-NFIB gene fusions in adenoid cystic carcinoma and other salivary neoplazma. Mod Pathol 2011;24(9):1169-76. Go to original source... Go to PubMed...
    29. Belloni E, Shing D, Tapinassi C, Viale A, Mancuso P, Malazzi O, Pelicci PG. In vivo expression of an aberrant MYB-GATA1 fusion induces leukemia in the presence of GATA1 reduced levels. Leukemia 2011;25(4):733. Go to original source... Go to PubMed...

    Return to the content