Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016, 160(4):499-502 | DOI: 10.5507/bp.2016.041

Procalcitonin is more likely to be released by the fetus rather than placental tissue during chorioamnionitis

Zbynek Stranaka,b, Jaroslav Feyereisla,b, Peter Korceka,b, Simona Feyereislovaa,b, Ladislav Kroftaa,b
a 3rd Faculty of Medicine, Charles University in Prague, Czech Republic
b Institute for the Care of Mother and Child, Prague, Czech Republic

Aims: To analyze the relationship between maternal, cord blood and neonatal procalcitonin (PCT) levels in preterm deliveries with and without histologically proven chorioamnionitis (HCA).

Methods: 91 mother-infant pairs from 24+0 to 33+0 gestational weeks were analyzed. Procalcitonin was measured in all mothers within 24 hours before and subsequently in cord blood and in neonates within the first two hours after delivery. PCT levels were analysed in relationship to HCA and clinical outcome.

Results: HCA was confirmed in 28 cases (31%). We found no differences in PCT values between HCA positive and negative groups in maternal blood (0.1±0.1 vs 0.09±0.09 ng/L, P = 0.76). PCT values in cord blood and neonates were significantly higher in the HCA positive compared to HCA negative group (0.23±0.1 vs 1.2±2.7 ng/L, P < 0.001 and 0.89±3.4 vs 4.2±9.3 ng/L, P < 0.0001 respectively). PCT values in neonates were significantly higher than those of cord blood. Levels were not influenced by the mode of delivery, gestational age or premature rupture of membranes. Chorioamnionitis was more frequently associated with early onset neonatal sepsis (36% in HCA group vs 5% in non HCA group, P < 0.0001). Comparison of other clinical data revealed no differences between HCA positive and negative groups.

Conclusion: This study showed higher PCT in cord and neonatal blood in the presence of proven histological chorioamnionitis. The measurement of PCT in mothers' blood is not helpful for diagnosis of HCA. The changes in PCT values shown suggest its production and release by fetal tissue.

Keywords: procalcitonin, preterm labor, intra-amniotic infection, early onset sepsis

Received: May 24, 2016; Accepted: July 29, 2016; Prepublished online: September 5, 2016; Published: December 12, 2016  Show citation

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Stranak, Z., Feyereisl, J., Korcek, P., Feyereislova, S., & Krofta, L. (2016). Procalcitonin is more likely to be released by the fetus rather than placental tissue during chorioamnionitis. Biomedical papers, 160(4), 499-502. doi: 10.5507/bp.2016.041
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    References

    1. Galinsky R, Polglase GR, Hooper SB et al. The consequences of chorioamnionitis: preterm birth and effects on development. J Pregnancy 2013; Article ID 412831 Go to original source...
    2. Howman RA, Charles AK, Jacques A, Doherty DA, Simmer K, Strunk T, Richmond PC,Cole CH, Burgner DP. Inflammatory and haematological markers in the maternal, umbilical cord and infant circulation in histological chorioamnionitis. PLoS One 2012;7(12):e51836. Go to original source... Go to PubMed...
    3. Su H, Chang SS, Han CM, Wu KY, Li MC, Huang CY, Lee CL, Wu JY, Lee CC. Inflammatory markers in cord blood or maternal serum for early detection of neonatal sepsis-a systemic review and meta-analysis. J Perinatol 2014;34(4):268-74. Go to original source... Go to PubMed...
    4. Spinillo A, Iacobone AD, Calvino IG, Alberi I, Gardella B. The role of the placenta in feto-neonatal infections. Early Hum Dev 2014,90(S1):S7-9. Go to original source... Go to PubMed...
    5. Thornburg LL, Queenan R, Brandt-Griffith B, Pressman EK. Procalcitonin for prediction of chorioamnionitis in preterm premature rupture of membranes. J Matern Fetal Neonatal Med 2016;29(13):2056-61. Go to original source... Go to PubMed...
    6. Chiesa C, Panero A, Rossi N, Stegagno M, De Giusti M, Osborn JF, Pacifico L. Reliability of procalcitonin concentrations for the diagnosis of sepsis in critically ill neonates. Clin Infect Dis 1998;26(3):664-72. Go to original source... Go to PubMed...
    7. Gibbs RS, Blanco JD, St Clair PJ, Castaneda YS. Quantitative bacteriology of amniotic fluid from women with clinical intra-amniotic infection at term. J Infect Dis 1982;145(1):1-8. Go to original source... Go to PubMed...
    8. Horbar JD. The Vermont Oxford Network: evidence-based quality improvement for neonatology. Pediatrics 1999;103(1):350-9. Go to original source... Go to PubMed...
    9. Nasef N, Shabaan AE, Schurr P, Iaboni D, Choudhury J, Church P, Dunn MS. Effect of clinical and histological chorioamnionitis on the outcome of preterm infants. Am J Perinatol 2013;30(1):59-68. Go to original source...
    10. Kim CJ, Romero R, Chaemsaithong P, Chaiyasit N, Yoon BH, Kim YM. Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance. Am J Obstet Gynecol 2015;213(S4):S29-52. Go to original source... Go to PubMed...
    11. Fishman SG, Gelber SE. Evidence for the clinical management of chorioamnionitis. Semin Fetal Neonatal Med 2012;17(1):46-50. Go to original source... Go to PubMed...
    12. Trochez-Martinez RD, Smith P, Lamont RF. Use of C-reactive protein as a predictor of chorioamnionitis in preterm prelabour rupture of membranes: a systematic review. BJOG 2007;114(7):796-801. Go to original source... Go to PubMed...
    13. Stepan M, Cobo T, Musilova I, Hornychova H, Jacobsson B, Kacerovsky M. Maternal Serum C-Reactive Protein in Women with Preterm Prelabor Rupture of Membranes. PLoS One 2016;11(3):e0150217. Go to original source... Go to PubMed...
    14. Lautridou A, Ancel PY, Launay E, Denizot S, Orsonneau JL, Roze JC, Gras-Le Guen C. Umbilical cord blood procalcitonin as a risk factor for mortality in very premature infants. Eur J Clin Microbiol Infect Dis 2012;31(9):2407-12. Go to original source... Go to PubMed...
    15. Altunhan H, Annagur A, Ors R, Mehmetoglu I. Procalcitonin measurement at 24 hours of age may be helpful in the prompt diagnosis of early-onset neonatal sepsis. International Journal of Infectious Diseases 2011;15:e854-e858. Go to original source... Go to PubMed...
    16. Linscheid P, Seboek D, Nylen ES, Langer I, Schlatter M, Keller U, Becker KL, Müller B. In vitro and in vivo calcitonin-I gene expression in parenchymal cells: a novel product of human adipose tissue. Endocrinol 2003;144,5578-84. Go to original source... Go to PubMed...

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