Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2020, 164(2):189-195 | DOI: 10.5507/bp.2019.016

Associations of cholesteryl ester transfer protein (CETP) gene variants with pituitary adenoma

Agne Sidaraite^a, Rasa Liutkeviciene^b,c, Brigita Glebauskiene^c, Alvita Vilkeviciute^b, Loresa Kriauciuniene^b,c

^a Lithuanian University of Health Sciences, Medical Academy, Eiveniu 2, Kaunas, Lithuania

^b Neuroscience Institute, Lithuanian University of Health Sciences, Medical Academy, Eiveniu 2, Kaunas, Lithuania

^c Department of Ophthalmology, Lithuanian University of Health Sciences, Medical Academy, Eiveniu 2, Kaunas, Lithuania

Aim: The aim was to evaluate the association of CETP (rs5882 and rs708272) single nucleotide polymorphisms with the presence, invasiveness, hormonal activity and recurrence of pituitary adenoma (PA).

Methods: The study group included 142 patients with PA and the control group, 753 healthy subjects. The genotyping of CETP (rs5882 and rs708272) was performed using a real-time PCR method.

Results: After statistical analysis we found that CETP rs708272 genotype G/A under the over-dominant model was associated with the decreased odds of PA (OR=0.637; 95%CI: 0.443-0.917; P=0.015), active PA (OR=0.538; 95%CI: 0.335-0.865; P =0.01) and non-recurrent PA (OR=0.602; 95% CI: 0.402 - 0.902; P =0.014). When compared to controls, the rs708272 genotype G/A was less frequent in the active PA subgroup (37.5% vs 52.7%, P =0.009) and the non-recurrent PA subgroup (40.2% vs 52.7%, P=0.013), while the rs5882 genotype A/A was less frequent in the non-recurrent PA subgroup (37.5% vs 46.2%, P=0.015).

Conclusion: Our study showed that CETP rs708272 genotype G/A may be associated with a decreased risk of PA.

Keywords: pituitary adenoma, CETP rs5882, rs708272, gene polymorphism, tumor

Received: November 25, 2018; Revised: April 4, 2019; Accepted: April 4, 2019; Prepublished online: April 17, 2019; Published: June 18, 2020  Show citation