Two new stilbenoids cajanotone and cajanamide A (1-2), together with another six known ones (3- 8) and four known dihydroflavones (9-12), have been isolated from the leaves of Cajanus cajan. Their structures were elucidated based on spectroscopic studies. A possible pathway to the new compounds 1 and 2 has been proposed. In vitro cytotoxicities of selected compounds against cancer cell lines HepG2, MCF-7 and A549 have been evaluated. Compounds 7 and 8 show strong cytotoxity against all the tested cell lines (with IC50 values in the range of 3.5 - 6.0 μM), and compounds 1 and 3 showed strong to moderate activity against the three cell lines.
Graphical Abstract
Two New Stilbenoids from Cajanus cajan
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