Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3833

Full Length Research Paper

Antimicrobial activity of the leaf extract and fractions of Lupinus arboreus

Ohadoma S. C.
  • Ohadoma S. C.
  • Department of Pharmacology, Imo State University Owerri, Imo State, Nigeria.
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Nnatuanya I.
  • Nnatuanya I.
  • Department of Medical Laboratory Sciences, Madonna University, Elele Rivers State, Nigeria.
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Amazu L. U.
  • Amazu L. U.
  • Department of Pharmacology, Imo State University Owerri, Imo State, Nigeria.
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Okolo C. E.
  • Okolo C. E.
  • Department of Pharmacology, Imo State University Owerri, Imo State, Nigeria.
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  •  Accepted: 31 January 2014
  •  Published: 25 February 2014

Abstract

The antimicrobial effect of the leaf extract and fractions of Lupinus arboreus was investigated. The crude methanol extract (CME) of the dried leaves obtained by 48 h cold maceration was fractionated into n-hexane fraction (HEF), ethyl acetate fraction (EAF), and methanol fraction (MEF); and evaluated using modified agar-well diffusion method. The results showed that the extract and fractions at varying concentrations, exerted strong antimicrobial activity on some of the test organisms. However, a weak activity was observed on the tested fungi-Aspergillus niger and Candida albicans. Ethyl acetate fraction showed the highest activity on many organisms than extract and other fractions.

Key words: Lupinus arboreus, antimicrobial activity, standard drugs, test organisms, extracts and fractions.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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