Lignan and Neolignan Glycosides from the Roots of Glehnia littoralis

 

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Abstract

A new lignan glycoside [glehlinoside G (1)] and three new neolignan glycosides [glehlinosides H (2), I (3) and J (4)] were isolated from the roots of Glehnia littoralis. Their structures were elucidated on the basis of spectroscopic data. The above glehlinosides (1–4), together with the other lignan and neolignan glycosides (5–12) from this plant, were evaluated for their prolyl oligopeptidase inhibitory activities, and a caffeoyled lignan glycoside (glehlinoside F, 8) exhibited a noticeable activity (IC₅₀ = 14.5 µM).

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Dr. Zhong Yuan

Department of Analysis of Traditional Chinese Medicine
School of Traditional Chinese Materia Medica
Shenyang Pharmaceutical University

Wenhua Road 103

110016 Shenyang

People's Republic of China

Phone: + 86 24 23 98 64 69

Fax: + 86 24 24 82 43 52

Email: yuanzhong@syphu.edu.cn