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CC BY 4.0 · Int Arch Otorhinolaryngol 2024; 28(02): e196-e202
DOI: 10.1055/s-0043-1773762
Original Research

Three-Dimensional Volumetric Investigation of Onodi Cells: A Multi-Slice Computed Tomography Study

Flavia Limberg Dieguez 
1   Postgraduate Program in Dentistry, Universidade Cruzeiro do Sul (UNICSUL), São Paulo, SP, Brazil
,
Catharina Simioni De Rosa 
2   Division of General Pathology, Department of Stomatology, Faculdade de Odontologia, Universidade de São Paulo (USP), São Paulo, SP, Brazil
,
Paulo Henrique Braz-Silva 
2   Division of General Pathology, Department of Stomatology, Faculdade de Odontologia, Universidade de São Paulo (USP), São Paulo, SP, Brazil
3   Virology Department, Laboratory of Virology, Instituto de Medicina Tropical de São Paulo, Faculdade de Medicina, Universidade deSão Paulo (USP), São Paulo, SP, Brazil
,
Sergio Lucio Pereira de Castro Lopes 
4   Department of Diagnosis and Surgery, Instituto de Ciência e Tecnologia, Universidade Estadual Paulista (Unifesp), São José dos Campos, SP, Brazil
,
Andre Luiz Ferreira Costa 
1   Postgraduate Program in Dentistry, Universidade Cruzeiro do Sul (UNICSUL), São Paulo, SP, Brazil
› Author Affiliations Funding The present research was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
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Abstract

Introduction Onodi cells (OCs) are posterior ethmoid cells that are located above the sphenoid sinus, close to or even surrounding the carotid artery and optic nerve.

Objective To investigate and evaluate the volumetric variation of OCs through multi-slice computed tomography (MSCT) scans.

Methods We performed a retrospective review of MSCT scans of 79 subjects, 40 male and 39 female patients, Whose age ranged from 18 to 83 (mean: 39.6) years. The volumes of the OCs on the right and left sides were measured using the ITK-SNAP software (open-source) with semiautomatic segmentation. The possible relationships involving age, gender, contact with the optic nerve, extension of the pneumatization of the posterior ethmoid cells into the clinoid processes, mucous thickening in the anterior and posterior ethmoid cells, and obliteration of the sphenoethmoidal complex were analyzed with the Pearson correlation and Chi-squared tests according to the type of data compared and logistic regression models (p < 0.05).

Results We observed that an increase of one unit in the volume of OCs also increases the chance of extension of pneumatization into the clinoid processes by 0.15% (p = 0.001). No significant correlations were identified regarding age, gender, and volume of the OCs.

Conclusion The volume of the OCs has effects on the extension of pneumatization into the clinoid processes.

Keywords

paranasal sinuses - diagnostic imaging - three-dimensional imaging - anatomic variation - pneumatization


Publication History

Received: 24 March 2023

Accepted: 28 May 2023

Article published online:
26 September 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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  • References

  • 1 Dasar U, Gokce E. Evaluation of variations in sinonasal region with computed tomography. World J Radiol 2016; 8 (01) 98-108
    CrossrefPubMedGoogle Scholar
  • 2 Hwang SH, Joo YH, Seo JH, Cho JH, Kang JM. Analysis of sphenoid sinus in the operative plane of endoscopic transsphenoidal surgery using computed tomography. Eur Arch Otorhinolaryngol 2014; 271 (08) 2219-2225 DOI: 10.1007/s00405-013-2838-9.
    CrossrefPubMedGoogle Scholar
  • 3 Ali IK, Sansare K, Karjodkar F, Saalim M. Imaging Analysis of Onodi Cells on Cone-Beam Computed Tomography. Int Arch Otorhinolaryngol 2020; 24 (03) e319-e322
    Article in Thieme ConnectPubMedGoogle Scholar
  • 4 Driben JS, Bolger WE, Robles HA, Cable B, Zinreich SJ. The reliability of computerized tomographic detection of the Onodi (Sphenoethmoid) cell. Am J Rhinol 1998; 12 (02) 105-111 DOI: 10.2500/105065898781390325.
    CrossrefPubMedGoogle Scholar
  • 5 Nitinavakarn B, Thanaviratananich S, Sangsilp N. Anatomical variations of the lateral nasal wall and paranasal sinuses: A CT study for endoscopic sinus surgery (ESS) in Thai patients. J Med Assoc Thai 2005; 88 (06) 763-768
    PubMedGoogle Scholar
  • 6 Cellina M, Gibelli D, Floridi C. et al. Sphenoid sinuses: pneumatisation and anatomical variants-what the radiologist needs to know and report to avoid intraoperative complications. Surg Radiol Anat 2020; 42 (09) 1013-1024 DOI: 10.1007/s00276-020-02490-y.
    CrossrefPubMedGoogle Scholar
  • 7 Sapçi T, Derin E, Almaç S, Cumali R, Saydam B, Karavuş M. The relationship between the sphenoid and the posterior ethmoid sinuses and the optic nerves in Turkish patients. Rhinology 2004; 42 (01) 30-34
    PubMedGoogle Scholar
  • 8 Papadopoulou AM, Chrysikos D, Samolis A, Tsakotos G, Troupis T. Anatomical Variations of the Nasal Cavities and Paranasal Sinuses: A Systematic Review. Cureus 2021; 13 (01) e12727
    PubMedGoogle Scholar
  • 9 Mazzurco M, Pavone P, Di Luca M. et al. Optic Neuropathy, Secondary to Ethmoiditis, and Onodi Cell Inflammation during Childhood: A Case Report and Review of the Literature. Neuropediatrics 2019; 50 (06) 341-345 DOI: 10.1055/s-0039-1693156.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 10 Farhan N, Naqvi SU, Rasheed B. et al. Identification of Significant Anatomical Variations in the Nose and Anterior Skull Base Using Computed Tomography: A Cross-Sectional Study. Cureus 2020; 12 (06) e8449
    PubMedGoogle Scholar
  • 11 Ozturan O, Yenigun A, Degirmenci N, Aksoy F, Veyseller B. Co-existence of the Onodi cell with the variation of perisphenoidal structures. Eur Arch Otorhinolaryngol 2013; 270 (07) 2057-2063 DOI: 10.1007/s00405-012-2325-8.
    CrossrefPubMedGoogle Scholar
  • 12 Özdemir A, Bayar Muluk N, Asal N, Şahan MH, Inal M. Is there a relationship between Onodi cell and optic canal?. Eur Arch Otorhinolaryngol 2019; 276 (04) 1057-1064 DOI: 10.1007/s00405-019-05284-0.
    CrossrefPubMedGoogle Scholar
  • 13 Doubi A, Albathi A, Sukyte-Raube D, Castelnuovo P, Alfawwaz F, AlQahtani A. Location of the Sphenoid Sinus Ostium in Relation to Adjacent Anatomical Landmarks. Ear Nose Throat J 2021; 100 (10_suppl, suppl) 961S-968S DOI: 10.1177/0145561320927907.
    CrossrefPubMedGoogle Scholar
  • 14 Chmielik LP, Chmielik A. The prevalence of the Onodi cell - Most suitable method of CT evaluation in its detection. Int J Pediatr Otorhinolaryngol 2017; 97: 202-205 DOI: 10.1016/j.ijporl.2017.04.001.
    CrossrefPubMedGoogle Scholar
  • 15 Lee JM, Au M. Onodi cell mucocele: Case report and review of the literature. Ear Nose Throat J 2016; 95 (09) E4-E8 DOI: 10.1177/014556131609500905.
    CrossrefPubMedGoogle Scholar
  • 16 Abuzayed B, Tanriover N, Biceroglu H. et al. Pneumatization degree of the anterior clinoid process: a new classification. Neurosurg Rev 2010; 33 (03) 367-373 , discussion 374 DOI: 10.1007/s10143-010-0255-8.
    CrossrefPubMedGoogle Scholar
  • 17 OuYang WL, Long C, Azam S. et al. Sphenoethmoidal air cell sinusitis: A rare cause of recurrent optic neuritis. Am J Ophthalmol Case Rep 2022; 26: 101485
    CrossrefPubMedGoogle Scholar
  • 18 Odat H, Almardeeni D, Tanash M, Al-Qudah M. Anatomical variation of the sphenoid sinus in paediatric patients and its association with age and chronic rhinosinusitis - ERRATUM. J Laryngol Otol 2019; 133 (08) 739 DOI: 10.1017/S002221511900118X.
    CrossrefPubMedGoogle Scholar
  • 19 Tzamalis A, Diafas A, Riga P, Konstantinidis I, Ziakas N. Onodi Cell Mucocele-Associated Optic Neuropathy: A Rare Case Report and Review of the Literature. J Curr Ophthalmol 2020; 32 (01) 107-113
    PubMedGoogle Scholar
  • 20 Cheon YI, Hong SL, Roh HJ, Cho KS. Fungal ball within Onodi cell mucocele causing visual loss. J Craniofac Surg 2014; 25 (02) 512-514 DOI: 10.1097/SCS.0000000000000678.
    CrossrefPubMedGoogle Scholar