Cytotoxic Neolignans from the Stem Wood of Machilus obovatifolia

 

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Abstract

Four new cytotoxic neolignans, machilusol A (1), machilusol C (3), machilusol D (4), machilusol E (5) as well as two new inactive neolignans, machilusol B (2) and machilusol F (6), were isolated from the stem wood of Machilus obovatifolia. All structures were identified by means of spectroscopic analysis.

References

• 1 Liao  J C.. Lauraceae in Flora of Taiwan, Editorial Committee of the Flora of Taiwan, 2nd edn., Vol. II, Taipei, Taiwan,; 1996: 481-2
• 2 Chang  C E.. Lauraceae in Flora of Taiwan, Editorial Committee of the Flora of Taiwan, Epoch Publishing Co., 1st edn., Vol. II, Taipei, Taiwan,; 1976: 460-2
• 3 Tsai  I L,, Hsieh  C F,, Duh  C Y,, Chen  I S.. Cytotoxic neolignans from Persea obovatifolia. .  Phytochemistry. 1996;;  43 1261-3
  CrossrefPubMedGoogle Scholar
• 4 Tsai  I L,, Hsieh  C F,, Duh  C Y.. Additional cytotoxic neolignans from Persea obovatifolia. .  Phytochemistry. 1998;;  48 1371-5
  CrossrefPubMedGoogle Scholar
• 5 Tsai  I L,, Hsieh  C F,, Duh  C Y,, Chen  I S.. Further study on the chemical constituents and their cytotoxicity from the leaves of Persea obovatifolia. .  The Chinese Pharmaceutical Journal. 1999;;  51 335-45
  PubMedGoogle Scholar
• 6 Mosmann  T.. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.  Journal of Immunological Methods. 1983;;  65 55-63
  CrossrefPubMedGoogle Scholar
• 7 Pintao  A M,, Pais  M SS,, Coley  H,, Kelland  L R,, Judson  I R.. In vitro and in vivo antitumor activity of benzyl isothiocyanate: A natural product from Tropaeolum majus. .  Planta Medica. 1995;;  61 233-6
  PubMedGoogle Scholar
• 8 Chen  J J,, Ishikawa  T,, Duh  C Y,, Tsai  I L,, Chen  I S.. New dimeric aporphine alkaloids and cytotoxic constituents of Hernandia nymphaeifolia. .  Planta Medica. 1996;;  62 528-33
  PubMedGoogle Scholar
• 9 Ito  K,, Ichino  K,, Iida  T,, Lai  J.. Neolignans from Magnolia kachirachirai. .  Phytochemistry. 1984;;  23 2643-5
  CrossrefPubMedGoogle Scholar
• 10 Nabeta  K,, Hirata  M,, Ohki  Y,, Samaraweera  S WA,, Okuyama  H.. Lignans in cell cultures of Picea glehnii. .  Phytochemistry. 1994;;  37 409-13
  CrossrefPubMedGoogle Scholar
• 11 Shimomura  H,, Sashida  Y,, Oohara  M.. Lignans from Machilus thunbergii. .  Phytochemistry. 1987;;  26 1513-5
  CrossrefPubMedGoogle Scholar
• 12 Achenbach  H,, Grob  J,, Dominguez  X A,, Cano  G,, Star  J V,, Brussolo  L DC,, Munoz  G,, Salgado  F,, Lopez  L.. Lignans, neolignans and norneolignans from Krameria cystisoides. .  Phytochemistry. 1987;;  26 1159-66
  CrossrefPubMedGoogle Scholar
• 13 Ferri  P H,, Barata  L ES.. Neolignans and a phenylpropanoid from Virola pavonis leaves.  Phytochemistry. 1992;;  31 1375-7
  CrossrefPubMedGoogle Scholar
• 14 Forrest  J E,, Heacock  R A,, Forrest  T P.. Diarylpropanoids from nutmeg and marce (Myristica fragrans Hout.).  Journal of the Chemical Socciety Perkin Transactions. I 1974:;  205-9
  PubMedGoogle Scholar
• 15 Hada  S,, Hattori  M,, Tezuka  Y,, Kikuchi  T,, Namba  T.. New neolignans and lignans from the aril of Myristica fragrans. .  Phytochemistry. 1988;;  27 563-8
  CrossrefPubMedGoogle Scholar

D. Ph. Prof. Ian-Lih Tsai

Graduate Institute of Natural Products Kaohsiung Medical University

Kaohsiung, Taiwan

Republic of China

Email: ialits@cc.kmu.edu.tw

Phone: 886-7-321-0683