Download PDF
Am J Perinatol 2002; 19(5): 239-240
DOI: 10.1055/s-2002-33086
Copyright © 2002 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Breast Engorgement and Galactorrhea during Magnesium Sulfate Treatment of Preterm Labor

Samuel Lurie, Sigi Rotmensch, Noa Feldman, Marek Glezerman
  • Department of Obstetrics and Gynecology, Wolfson Medical Center, Holon, Israel
Further Information

Publication History

Publication Date:
09 August 2002 (online)

    Permissions and Reprints

ABSTRACT

Breast engorgement and galactorrhea occasionally occur during tocolysis with ritodrine. We are not aware of breast engorgement and galactorrhea associated with other tocolytics. We report the first case of breast engorgement and galactorrhea during tocolysis with intravenous magnesium sulfate in a generally healthy 24-year-old woman admitted for tocolysis at 30 weeks' gestation. Breast engorgement and galactorrhea gradually subsided after magnesium sulfate was discontinued. The rapid disappearance of both the galactorrhea and the breast engorgement after discontinuation of magnesium sulfate treatment suggests a cause-effect relationship, the mechanism of which remains unclear.

KEYWORDS

Galactorrhea - preterm labor - tocolysis

REFERENCES

  • 1 Biswas S, Rodeck C H. Plasma prolactin levels during pregnancy.  Br J Obstet Gynaecol . 1976;  83 683-687
    PubMedGoogle Scholar
  • 2 Shalev J, Frankel Y, Eshkol A, Serr D M. Breast engorgement and galactorrhea after preventing premature contractions with ritodrine.  Gynecol Obstet Invest . 1984;  17 190-193
    PubMedGoogle Scholar
  • 3 Wellnitz O, Bruckmaier R M, Albrecht C, Blum J W. Atosiban, an oxytocin receptor blocking agent: pharmacokinetics and inhibition of milk ejection in dairy cows.  J Dairy Res . 1999;  66 1-8
    PubMedGoogle Scholar
  • 4 Reynolds J EF. Martindale: The Extra Pharmacopoeia.  13th ed. London: The Pharmaceutical Press 1993: 138,712-725
    Google Scholar
      >