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In Vivo Microdialysis Technique Applications to Understand the Contribution of Receptor–Receptor Interactions to the Central Nervous System Signaling

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Receptor-Receptor Interactions in the Central Nervous System

Part of the book series: Neuromethods ((NM,volume 140))

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Abstract

During the last 50 years, microdialysis technique has been continuously improved to become a well-established method to monitor local concentrations of neurotransmitters. In respect to other currently used techniques, such as voltammetry, microdialysis has the advantage to be possibly applied to all measurable neurotransmitters and to allow local treatments. These properties render the technique a suitable approach to investigate, in vivo, the neurochemical consequences of receptor–receptor interactions, thus providing functional correlates to binding and other biochemical data.

This chapter is mainly focused on a general description of microdialysis technique in freely moving animals and on the application of one- or dual-probe(s) microdialysis to investigate the functional relevance of receptor–receptor interactions in rodent brain.

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Author information

Authors and Affiliations

  1. Department of Medical Sciences, Section of Pharmacology, University of Ferrara, Ferrara, Italy

    Sergio Tanganelli & Tiziana Antonelli

  2. Department of Life Sciences and Biotechnology, Section of Medicinal and Health Products, University of Ferrara, Ferrara, Italy

    Sarah Beggiato, Maria Cristina Tomasini & Luca Ferraro

  3. Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden

    Kjell Fuxe

  4. Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden

    Dasiel O. Borroto-Escuela

Authors
  1. Sergio Tanganelli
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  2. Tiziana Antonelli
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  3. Sarah Beggiato
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  4. Maria Cristina Tomasini
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  5. Kjell Fuxe
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  6. Dasiel O. Borroto-Escuela
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  7. Luca Ferraro
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Corresponding author

Correspondence to Sergio Tanganelli .

Editor information

Editors and Affiliations

  1. Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden

    KJELL FUXE

  2. Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden

    Dasiel O. Borroto-Escuela

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Tanganelli, S. et al. (2018). In Vivo Microdialysis Technique Applications to Understand the Contribution of Receptor–Receptor Interactions to the Central Nervous System Signaling. In: FUXE, K., Borroto-Escuela, D. (eds) Receptor-Receptor Interactions in the Central Nervous System. Neuromethods, vol 140. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8576-0_7

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  • DOI: https://doi.org/10.1007/978-1-4939-8576-0_7

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8575-3

  • Online ISBN: 978-1-4939-8576-0

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