Abstract
Neuropathic pain is defined by International Association for the Study of Pain as “pain initiated or caused by a primary lesion or dysfunction in the nervous system which can persist long after the initial injury has healed”. Given the complexity of neuropathic pain (“lesion or dysfunction” encompasses a wide variety of disease states, ranging from trauma through neurotoxins and infections to metabolic disturbances), it is hardly surprising that an array of models has been developed for this pain condition, many of which are described in this volume. This chapter addresses the clinical correlates of these pain models.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
McMahon S, Koltzenburg M (eds) (2005) Wall and Melzack’s textbook of pain, 5th edn. Churchill Livingston
Treede RD, Jensen TS, Campbell JN, Cruccu G, Dostrovsky JO, Griffin JW, Hansson P, Hughes R, Nurmikko T, Serra J (2008) Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology 47:1630–1635
Kim SH, Chung JM (1992) An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 50:355–363
Hu SJ, Xing JL (1998) An experimental model for chronic compression of dorsal root ganglion produced by intervertebral foramen stenosis in the rat. Pain 77:15–23
Bester H, Beggs S, Woolf CJ (2000) Changes in tactile stimuli-induced behavior and c-fos expression in the superficial dorsal horn and in parabrachial nuclei after sciatic nerve crush. J Comp Neurol 428:45–61
Coderre TJ, Xanthos DN, Francis L, Bennett GJ (2004) Chronic post-ischemia pain (CPIP): a novel animal model of complex regional pain syndrome-type I (CRPS-I; reflex sympathetic dystrophy) produced by prolonged hindpaw ischemia and reperfusion in the rat. Pain 112:94–105
Decosterd I, Woolf CJ (2000) Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain 87:149–158
Bennett GJ, Xie YK (1988) A peripheral mononeuropathy in rat produces disorders of pain sensation like those seen in man. Pain 33:87–107
Rivera L, Gallar J, Pozzo MA, Belmonte C (2000) Responses of nerve fibres of the rar saphenous nerve neuroma to mechanical and chemical stimulation. J Physiol 527:305–313
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer Science+Business Media, LLC
About this protocol
Cite this protocol
Szallasi, A. (2010). Human Correlates of Animal Models of Chronic Pain. In: Szallasi, A. (eds) Analgesia. Methods in Molecular Biology, vol 617. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-323-7_11
Download citation
DOI: https://doi.org/10.1007/978-1-60327-323-7_11
Published:
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-60327-322-0
Online ISBN: 978-1-60327-323-7
eBook Packages: Springer Protocols