Abstract
Pain is one of the most common reasons for which patients seek dental and medical care. Orofacial pain conditions consist of a wide range of disorders including odontalgia (toothache), temporomandibular disorders, trigeminal neuralgia and others. Most of these conditions are either inflammatory or neuropathic in nature. This chapter provides an overview of the commonly used models to study inflammatory and neuropathic orofacial pain.
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References
Lipton JA, Ship JA, Larach-Robinson D (1993) Estimated prevalence and distribution of reported orofacial pain in the United States. J Am Dent Assoc 124:115–121
Locker D, Slade G (1988) Prevalence of symptoms associated with temporomandibular disorders in a Canadian population. Community Dent Oral Epidemiol 16:310–313
Von Korff M, Dworkin SF, Le Resche L, Kruger A (1988) An epidemiologic comparison of pain complaints. Pain 32:173–183
Bereiter DA, Hargreaves KM, Hu JW (In press) Trigeminal mechanisms of nociception: peripheral and brainstem organization. In: Basbaum A, Bushnell C (eds) Handbook of the senses. vol 1
Byers MR, Narhi MV (1999) Dental injury models: experimental tools for understanding neuroinflammatory interactions and polymodal nociceptor functions. Crit Rev Oral Biol Med 10:4–39
Khayat BG, Byers MR, Taylor PE, Mecifi K, Kimberly CL (1988) Responses of nerve fibers to pulpal inflammation and periapical lesions in rat molars demonstrated by calcitonin gene-related peptide immunocytochemistry. J Endod 14:577–587
Kimberly CL, Byers MR (1988) Inflammation of rat molar pulp and periodontium causes increased calcitonin gene-related peptide and axonal sprouting. Anat Rec 222:289–300
Kakehashi S, Stanley HR, Fitzgerald RJ (1965) The effects of surgical exposures of dental pulps in germ-free and conventional laboratory rats. Oral Surg Oral Med Oral Pathol 20:340–349
Wang CY, Stashenko P (1991) Kinetics of bone-resorbing activity in developing periapical lesions. J Dent Res 70:1362–1366
Wang CY, Tani-Ishii N, Stashenko P (1997) Bone-resorptive cytokine gene expression in periapical lesions in the rat. Oral Microbiol Immunol 12:65–71
Byers MR, Taylor PE, Khayat BG, Kimberly CL (1990) Effects of injury and inflammation on pulpal and periapical nerves. J Endod 16:78–84
Kawashima N, Niederman R, Hynes RO, Ullmann-Cullere M, Stashenko P (1999) Infection-stimulated infraosseus inflammation and bone destruction is increased in P-/E-selectin knockout mice. Immunology 97:117–123
Tani-Ishii N, Wang CY, Stashenko P (1995) Immunolocalization of bone-resorptive cytokines in rat pulp and periapical lesions following surgical pulp exposure. Oral Microbiol Immunol 10:213–219
Kawashima N, Stashenko P (1999) Expression of bone-resorptive and regulatory cytokines in murine periapical inflammation. Arch Oral Biol 44:55–66
Ro JY (2005) Bite force measurement in awake rats: a behavioral model for persistent orofacial muscle pain and hyperalgesia. J Orofac Pain 19:159–167
Zhou Q, Imbe H, Dubner R, Ren K (1999) Persistent Fos protein expression after orofacial deep or cutaneous tissue inflammation in rats: implications for persistent orofacial pain. J Comp Neurol 412:276–291
Morgan JR, Gebhart GF (2008) CharacÂterizaÂtion of a model o chronic orofacial hyperalgesia in the rat: contribution of NaV 1.8. J Pain 9:522–531
Bereiter DA, Benetti AP (1996) Excitatory amino release within spinal trigeminal nucleus after mustard oil injection into the temporomandibular joint region of the rat. Pain 67:451–459
Bonjardim LR, da Silva AP, Gameiro GH, Tambeli CH, de Arruda F, Veiga MC (2009) Nociceptive behavior induced by mustard oil injection into the temporomandibular joint is blocked by a peripheral non-opioid analgesic and a central opioid analgesic. Pharmacol BioÂchem Behav 91:321–326
Haas DA, Nakanishi O, MacMillan RE, Jordan RC, Hu JW (1992) Development of an orofacial model of acute inflammation in the rat. Arch Oral Biol 37:417–422
Akopian A, Ruparel N, Jeske N, Hargreaves KM (2007) TRPA1 desensitization in sensory neurons is agonist-dependent and regulated by TRPV1-directed internalization. J Physiol 583:175–193
Chiang CY, Park SJ, Kwan CL, Hu JW, Sessle BJ (1998) NMDA receptor mechanisms contribute to neuroplasticity induced in caudalis nociceptive neurons by tooth pulp stimulation. J Neurophysiol 80:2621–2631
Zhang S, Chiang CY, Xie YF, Park SJ, Lu Y, Hu JW, Dostrovsky JO, Sessle BJ (2006) Central sensitization in thalamic nociceptive neurons induced by mustard oil application to rat molar tooth pulp. Neuroscience 142:833–842
Clavelou P, Dallel R, Orliaguet T, Woda A, Raboisson P (1995) The orofacial formalin test in rats: effects of different formalin concentrations. Pain 62:295–301
Gilbert SD, Clark TM, Flores CM (2001) Antihyperalgesic activity of epibatidine in the formalin model of facial pain. Pain 89:159–165
Porro CA, Cavazzuti M (1993) Spatial and temporal aspects of spinal cord and brainstem activation in the formalin pain model. Prog Neurobiol 41:565–607
Raboisson P, Bourdiol P, Dallel R, Clavelou P, Woda A (1991) Responses of trigeminal subnucleus oralis nociceptive neurones to subcutaneous formalin in the rat. Neurosci Lett 125:179–182
Raboisson P, Dallel R (2004) The orofacial formalin test. Neurosci Biobehav Rev 28:219–226
Szolcsanyi J (2004) Forty years in capsaicin research for sensory pharmacology and physiology. Neuropeptides 38:377–384
Knotkova H, Pappagallo M, Szallasi A (2008) Capsaicin (TRPV1 Agonist) therapy for pain relief: farewell or revival? Clin J Pain 24:142–154
Chidiac JJ, Hawwa N, Baliki M, Safieh-Garabedian B, Rifai K, Jabbur SJ, Saade NE (2001) A perfusion technique for the determination of pro-inflammatory mediators induced by intradental application of irritants. J Pharmacol Toxicol Methods 46:125–130
Chidiac JJ, Rifai K, Hawwa NN, Massaad CA, Jurjus AR, Jabbur SJ, Saade NE (2002) Nociceptive behaviour induced by dental application of irritants to rat incisors: a new model for tooth inflammatory pain. Eur J Pain 6:55–67
Diogenes A, Patwardhan A, Ruparel N, Goffin A, Akopian A, Hargreaves KM (2006) Prolactin modulates TRPV1 in female rat trigeminal sensory neurons. J Neurosci 26:8126–8136
Bowles WR, Flores CM, Jackson DL, Hargreaves KM (2003) beta 2-Adrenoceptor regulation of CGRP release from capsaicin-sensitive neurons. J Dent Res 82:308–311
Hargreaves KM, Jackson DL, Bowles WR (2003) Adrenergic regulation of capsaicin-sensitive neurons in dental pulp. J Endod 29:397–399
Anderson LC, Vakoula A, Veinote R (2003) Inflammatory hypersensitivity in a rat model of trigeminal neuropathic pain. Arch Oral Biol 48:161–169
Henry MA, Freking AR, Johnson LR, Levinson SR (2007) Sodium channel Nav1.6 accumulates at the site of infraorbital nerve injury. BMC Neurosci 8:56
Vos BP, Strassman AM, Maciewicz RJ (1994) Behavioral evidence of trigeminal neuropathic pain following chronic constriction injury to the rat’s infraorbital nerve. J Neurosci 14:2708–2723
Pan Y, Wheeler EF, Bernanke JM, Yang H, Naftel JP (2003) A model experimental system for monitoring changes in sensory neuron phenotype evoked by tooth injury. J Neurosci Methods 126:99–109
Wheeler EF, Naftel JP, Pan M, von Bartheld CS, Byers MR (1998) Neurotrophin receptor expression is induced in a subpopulation of trigeminal neurons that label by retrograde transport of NGF or fluoro-gold following tooth injury. Brain Res Mol Brain Res 61:23–38
Ambalavanar R, Moritani M, Haines A, Hilton T, Dessem D (2003) Chemical phenotypes of muscle and cutaneous afferent neurons in the rat trigeminal ganglion. J Comp Neurol 26:167–179
Eckert SP, Taddese A, McCleskey EW (1997) Isolation and culture of rat sensory neurons having distinct sensory modalities. J Neurosci Methods 77:183–190
Stephenson JL, Byers MR (1995) GFAP immunoreactivity in trigeminal ganglion satellite cells after tooth injury in rats. Exp Neurol 131:11–22
Sugaya A, Chudler EH, Byers MR (1995) Axonal transport of fluorescent carbocyanine dyes allows mapping of peripheral nerve territories in gingiva. J Periodontol 66:817–821
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Khan, A., Hargreaves, K.M. (2010). Animal Models of Orofacial Pain. In: Szallasi, A. (eds) Analgesia. Methods in Molecular Biology, vol 617. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-323-7_8
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DOI: https://doi.org/10.1007/978-1-60327-323-7_8
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