Skip to main content
SpringerLink
Log in

Abraxas

  • Reference work entry
  • First Online:
Encyclopedia of Cancer

  • 159 Accesses

Definition

BRCA1-A complex subunit Abraxas. Component of the BRCA1-A complex, a complex that specifically recognizes “Lys-63”-linked ubiquitinated (see “Ubiquitination”) histones H2A and gamma-H2AX at DNA damage sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes “Lys-63”-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1. Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.

Cross-References

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 2,499.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 3,999.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

See Also

  • (2012) BRCA1. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 481. doi: 10.1007/978-3-642-16483-5_6868

    Google Scholar 

  • (2012) Double Strand Break. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1156. doi: 10.1007/978-3-642-16483-5_1718

    Google Scholar 

  • (2012) GammaH2AX. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1494. doi: 10.1007/978-3-642-16483-5_2576

    Google Scholar 

  • (2012) Histones. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1706. doi: 10.1007/978-3-642-16483-5_2762

    Google Scholar 

  • (2012) RAP80. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3173. doi: 10.1007/978-3-642-16483-5_6873

    Google Scholar 

Download references

Editor information

Editors and Affiliations

  1. German Cancer Research Center (DKFZ), Tumorgenetik, Heidelberg, Germany

    Manfred Schwab

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer International Publishing Switzerland

About this entry

Cite this entry

(2015). Abraxas. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-46875-3_6874

Download citation

Publish with us

Policies and ethics

Search

Navigation