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01.11.2007 | Original Paper

A Rat Surgical Model of Esophageal Metaplasia and Adenocarcinoma-Induced by Mixed Reflux of Gastric Acid and Duodenal Contents

verfasst von: Tao Zhang, Feng Zhang, Yong Han, Zhongping Gu, Yong’an Zhou, Qingshu Cheng, Yifang Zhu, Chuanshan Zhang, Yunjie Wang

Erschienen in: Digestive Diseases and Sciences | Ausgabe 11/2007

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Abstract

Recent clinical data have revealed that mixed reflux (MR) of gastric acid and duodenal contents frequently occurs in patients with gastroesophageal reflux disease and a progressive increase of MR occurs with increasing severity across gastroesophageal reflux disease. Herein we report a novel rat surgical model in which esophageal metaplasia and adenocarcinoma develop as complications of MR. The model was created by performing an esophagojejunostomy and a gastrojejunostomy 5 mm proximal to the esophagojejunal anastomosis in 40 rats. Severe inflammatory and proliferative changes, high prevalence of esophageal metaplasia (78%), and adenocarcinoma (50%) were observed in the lower part of the esophagus of rats 20 weeks after surgery. The resulting esophageal lesions resembled those described in humans and supported a progression from intestinal metaplasia to dysplasia and, ultimately, esophageal adenocarcinoma. Such a model may provide a useful tool in study of human reflux-induced carcinogenesis.

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Titel: A Rat Surgical Model of Esophageal Metaplasia and Adenocarcinoma-Induced by Mixed Reflux of Gastric Acid and Duodenal Contents
verfasst von: Tao Zhang
Feng Zhang
Yong Han
Zhongping Gu
Yong’an Zhou
Qingshu Cheng
Yifang Zhu
Chuanshan Zhang
Yunjie Wang
Publikationsdatum: 01.11.2007
Verlag: Springer US
Erschienen in: Digestive Diseases and Sciences / Ausgabe 11/2007
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-007-9774-8

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