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Erschienen in: European Journal of Nutrition 6/2021

04.03.2021 | Original Contribution

Associations between maternal vitamin D status during three trimesters and cord blood 25(OH)D concentrations in newborns: a prospective Shanghai birth cohort study

verfasst von: Xirui Wang, Xianting Jiao, Ying Tian, Jun Zhang, Yue Zhang, Juan Li, Fan Yang, Mingqing Xu, Xiaodan Yu, for the Shanghai Birth Cohort Study

Erschienen in: European Journal of Nutrition | Ausgabe 6/2021

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Abstract

Purpose

Prenatal vitamin D (VitD) deficiency influences children’s health in later life. We aimed to test the associations between maternal VitD status in each of the three trimesters of pregnancy and cord blood 25(OH)D concentrations in newborns.

Methods

Participants were pregnant women recruited from the Shanghai Birth Cohort (SBC) (n = 1100). Of all the participants, 946 completed the collection of venous blood at early (< 16 weeks, T1), mid- (24–28 weeks, T2), and late (32–34 weeks, T3) pregnancy as well as the corresponding cord blood in the newborns. Maternal serum 25(OH)D concentrations were measured by LC–MS/MS, and the information on confounding factors was obtained through a standardized questionnaire.

Results

The mean 25(OH)D concentrations at time points T1, T2, T3 in maternal blood and cord blood of the newborns were 26.31 ng/mL, 31.92 ng/mL, 35.62 ng/mL, and 19.77 ng/mL, respectively. Neonatal 25(OH)D level in cord blood was positively correlated with maternal serum 25(OH)D levels at each trimester, and the strongest correlation was found at time point T3.

Conclusion

Maternal 25(OH)D concentrations at each trimester were positively associated with neonatal VitD status in cord blood, and the strongest correlation was found in the late stage of pregnancy, which could be considered as a sensitive time window. Attention should be paid to the nutritional status of VitD during pregnancy to better prevent the VitD deficiency in neonates.
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Metadaten
Titel
Associations between maternal vitamin D status during three trimesters and cord blood 25(OH)D concentrations in newborns: a prospective Shanghai birth cohort study
verfasst von
Xirui Wang
Xianting Jiao
Ying Tian
Jun Zhang
Yue Zhang
Juan Li
Fan Yang
Mingqing Xu
Xiaodan Yu
for the Shanghai Birth Cohort Study
Publikationsdatum
04.03.2021
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Nutrition / Ausgabe 6/2021
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-021-02528-w

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