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Erschienen in: Im Fokus Onkologie 12/2014

15.12.2014 | Zertifizierte Fortbildung

Metastasiertes Mammakarzinom

Biologisch stratifizierte Therapie

verfasst von: Dr. med. Isabel Sicking, PD Dr. med. Marcus Schmidt

Erschienen in: Im Fokus Onkologie | Ausgabe 12/2014

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Zusammenfassung

Das metastasierte Mammakarzinom verläuft chronisch-progredient und ist nicht mehr heilbar. Primäres Behandlungsziel ist es, Metastasen-bedingte Beschwerden zu lindern und die Lebensqualität zu erhalten. Für die Therapieentscheidung sind patientenbezogene Aspekte wie etwa das Alter relevant, aber auch krankheitsabhängige Faktoren wie der Rezeptorstatus.
Literatur
2.
Zurück zum Zitat Berry DA et al. Effect of screening and adjuvant therapy on mortality from breast cancer. N Engl J Med. 2005;353(17):1784–92.PubMedCrossRef Berry DA et al. Effect of screening and adjuvant therapy on mortality from breast cancer. N Engl J Med. 2005;353(17):1784–92.PubMedCrossRef
3.
Zurück zum Zitat O’Shaughnessy J. Extending survival with chemotherapy in metastatic breast cancer. Oncol. 2005;10(3):20–29.CrossRef O’Shaughnessy J. Extending survival with chemotherapy in metastatic breast cancer. Oncol. 2005;10(3):20–29.CrossRef
4.
Zurück zum Zitat Amir E et al. Prospective study evaluating the impact of tissue confirmation of metastatic disease in patients with breast cancer. J Clin Oncol. 2012;30(6):587–92.PubMedCrossRef Amir E et al. Prospective study evaluating the impact of tissue confirmation of metastatic disease in patients with breast cancer. J Clin Oncol. 2012;30(6):587–92.PubMedCrossRef
5.
Zurück zum Zitat Nabholtz JM et al. Anastozole is superior to tamoxifen as first-line therapy for advanced breast cancer in postmenopausal women: results of a North American multicenter randomized trial. Arimidex Study Group. J Clin Oncol. 2000;18(22):3758–67.PubMed Nabholtz JM et al. Anastozole is superior to tamoxifen as first-line therapy for advanced breast cancer in postmenopausal women: results of a North American multicenter randomized trial. Arimidex Study Group. J Clin Oncol. 2000;18(22):3758–67.PubMed
6.
Zurück zum Zitat Mouridsen H et al. Superior efficacy of letrozole versus tamoxifen as first-line therapy for postmenopausal women with advanced breast cancer: results of a phase III study of the International Letrozole Breast Cancer Group. J Clin Oncol. 2001;9(19):2596–606. Mouridsen H et al. Superior efficacy of letrozole versus tamoxifen as first-line therapy for postmenopausal women with advanced breast cancer: results of a phase III study of the International Letrozole Breast Cancer Group. J Clin Oncol. 2001;9(19):2596–606.
7.
Zurück zum Zitat Howell A et al. Fulvestrant, formerly ICI182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment. J Clin Oncol. 2002;20(16): 3396–3403.PubMedCrossRef Howell A et al. Fulvestrant, formerly ICI182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment. J Clin Oncol. 2002;20(16): 3396–3403.PubMedCrossRef
8.
Zurück zum Zitat Robertson JFR et al. Fulvestrant 500 mg versus anastrozole 1 mg for the first-line treatment of advanced breast cancer: follow-up analysis from the randomized ‚FIRST“ study. Breast Cancer Res Treat. 2012; 136(2):503–11.PubMedCrossRef Robertson JFR et al. Fulvestrant 500 mg versus anastrozole 1 mg for the first-line treatment of advanced breast cancer: follow-up analysis from the randomized ‚FIRST“ study. Breast Cancer Res Treat. 2012; 136(2):503–11.PubMedCrossRef
9.
Zurück zum Zitat Baselga J et al. Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Engl J Med. 2012;366(6):520–9.PubMedCrossRef Baselga J et al. Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Engl J Med. 2012;366(6):520–9.PubMedCrossRef
10.
Zurück zum Zitat Finn RS et al. Final Results of a Randomized Phase 2 Study of Palbociclib (PD 0332991) a Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor, in combination with Letrozole vs Letrozole Alone for First-Line Treatment of ER+, HER2-Advanced Breast Cancer (PALOMA-1/TRIO-18). AACR. 2014;Abstr CT101. Finn RS et al. Final Results of a Randomized Phase 2 Study of Palbociclib (PD 0332991) a Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor, in combination with Letrozole vs Letrozole Alone for First-Line Treatment of ER+, HER2-Advanced Breast Cancer (PALOMA-1/TRIO-18). AACR. 2014;Abstr CT101.
11.
Zurück zum Zitat Finn RS et al. PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro. Breast Cancer Res. 2009;11(5): R77.PubMedCentralPubMedCrossRef Finn RS et al. PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro. Breast Cancer Res. 2009;11(5): R77.PubMedCentralPubMedCrossRef
12.
Zurück zum Zitat Hudis CA. Trastuzumab - Mechanism of action and use in clinical Practice. N Engl J Med. 2007;357(1):39–51.PubMedCrossRef Hudis CA. Trastuzumab - Mechanism of action and use in clinical Practice. N Engl J Med. 2007;357(1):39–51.PubMedCrossRef
13.
Zurück zum Zitat Marty M et al. Randomized phase II trial of the efficacy and safety of trastzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positiv metastastic breast cancer administerd as first-line treatment: the M77001 study group. J Clin Oncol. 2005;23(19):4265–74.PubMedCrossRef Marty M et al. Randomized phase II trial of the efficacy and safety of trastzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positiv metastastic breast cancer administerd as first-line treatment: the M77001 study group. J Clin Oncol. 2005;23(19):4265–74.PubMedCrossRef
14.
Zurück zum Zitat Scheuer W et al. Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models. Cancer Res. 2009;69(24):9330–6.PubMedCrossRef Scheuer W et al. Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models. Cancer Res. 2009;69(24):9330–6.PubMedCrossRef
15.
Zurück zum Zitat Nahta R et al. The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells. Cancer Res. 2004;64(7):2343–6.PubMedCrossRef Nahta R et al. The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells. Cancer Res. 2004;64(7):2343–6.PubMedCrossRef
16.
Zurück zum Zitat Johnston S et al. Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer. J Clin Oncol. 2009;27(33):5538–46.PubMedCrossRef Johnston S et al. Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer. J Clin Oncol. 2009;27(33):5538–46.PubMedCrossRef
17.
Zurück zum Zitat Lin NU et al. Multicenter phase II study of lapatinib in patients with brain metastases from HER2-positive breast cancer. Clin Cancer Res. 2009;15(4):1452–9.PubMedCrossRef Lin NU et al. Multicenter phase II study of lapatinib in patients with brain metastases from HER2-positive breast cancer. Clin Cancer Res. 2009;15(4):1452–9.PubMedCrossRef
18.
Zurück zum Zitat Baselga J et al. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. N Engl J Med. 2012;366(2):109–19.PubMedCrossRef Baselga J et al. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. N Engl J Med. 2012;366(2):109–19.PubMedCrossRef
19.
Zurück zum Zitat Swain SM et al. Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study. Lancet Oncol. 2013;14(6):461–71.PubMedCentralPubMedCrossRef Swain SM et al. Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study. Lancet Oncol. 2013;14(6):461–71.PubMedCentralPubMedCrossRef
20.
Zurück zum Zitat Verma S et al. Trastuzumab emtansine for HER2-positive advanced breast cancer. N Engl J Med. 2012;367(19):1783–91.PubMedCrossRef Verma S et al. Trastuzumab emtansine for HER2-positive advanced breast cancer. N Engl J Med. 2012;367(19):1783–91.PubMedCrossRef
21.
Zurück zum Zitat Kaufman B et al. Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the randomized phase III TAnDEM study. J Clin Oncol. 2009;27(33):5529–37.PubMedCrossRef Kaufman B et al. Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the randomized phase III TAnDEM study. J Clin Oncol. 2009;27(33):5529–37.PubMedCrossRef
22.
Zurück zum Zitat Miller K et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med. 2007;357(26):2666–76.PubMedCrossRef Miller K et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med. 2007;357(26):2666–76.PubMedCrossRef
23.
Zurück zum Zitat Robert NJ et al. RIBBON-1: randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer. J Clin Oncol. 2011;29(10):1252–60.PubMedCrossRef Robert NJ et al. RIBBON-1: randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer. J Clin Oncol. 2011;29(10):1252–60.PubMedCrossRef
24.
Zurück zum Zitat O’Shaughnessy J et al. Iniparib plus Chemotherapy in Metastatic Triple-Negative Breast Cancer. N Engl J Med. 2011;364(3):205–14.PubMedCrossRef O’Shaughnessy J et al. Iniparib plus Chemotherapy in Metastatic Triple-Negative Breast Cancer. N Engl J Med. 2011;364(3):205–14.PubMedCrossRef
25.
Zurück zum Zitat O’Shaughnessy J et al. A randomized phase III study of iniparib (BSI-201) in combination with gemcitabine/carboplatin (G/C) in metastatic triple-negative breast cancer (TNBC). J Clin Oncol. 2011;29(suppl):Abstr 1007. O’Shaughnessy J et al. A randomized phase III study of iniparib (BSI-201) in combination with gemcitabine/carboplatin (G/C) in metastatic triple-negative breast cancer (TNBC). J Clin Oncol. 2011;29(suppl):Abstr 1007.
26.
Zurück zum Zitat Anders C et al. TBCRC 018: phase II study of iniparib in combination with irinotecan to treat progressive triple negative breast cancer brain metastases. Breast Cancer Res Treat. 2014;146(3):557–66.PubMedCentralPubMedCrossRef Anders C et al. TBCRC 018: phase II study of iniparib in combination with irinotecan to treat progressive triple negative breast cancer brain metastases. Breast Cancer Res Treat. 2014;146(3):557–66.PubMedCentralPubMedCrossRef
Metadaten
Titel
Metastasiertes Mammakarzinom
Biologisch stratifizierte Therapie
verfasst von
Dr. med. Isabel Sicking
PD Dr. med. Marcus Schmidt
Publikationsdatum
15.12.2014
Verlag
Urban & Vogel
Erschienen in
Im Fokus Onkologie / Ausgabe 12/2014
Print ISSN: 1435-7402
Elektronische ISSN: 2192-5674
DOI
https://doi.org/10.1007/s15015-014-0011-y

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