Background
Methods
Data source
Study population
Exposure and outcome
Covariates
Statistical analysis
Characteristics | Clopidogrel plus aspirin | Aspirin alone | p |
---|---|---|---|
(n = 159) | (n = 834) | ||
Age (years, mean ± SE) | 64.6 ± 1.0 | 68.3 ± 0.4 | 0.0005 |
Women | 32 (20.13%) | 329 (39.45%) | <0.0001 |
Medical history
| |||
Cerebrovascular disease | 40 (25.16%) | 375 (44.96%) | <0.0001 |
Ischemic heart disease | 140 (88.05%) | 536 (64.27%) | <0.0001 |
Liver disease | 38 (23.9%) | 369 (44.24%) | <0.0001 |
Kidney disease | 57 (35.85%) | 378 (45.32%) | 0.0273 |
Hypertension | 107 (67.3%) | 495 (59.35%) | 0.0603 |
Diabetes mellitus | 122 (76.73%) | 606 (72.66%) | 0.2879 |
Hyperlipidemia | 147 (92.45%) | 668 (80.10%) | 0.0002 |
Current medication
| |||
Insulin | 3 (1.89%) | 60 (7.19%) | 0.0119 |
Oral hypoglycemic drug | 25 (15.72%) | 106 (12.71%) | 0.3035 |
Lipid-lowering drug | 38 (23.9%) | 144 (17.27%) | 0.0476 |
Antihypertensive drug | 51 (32.08%) | 590 (70.74%) | <0.0001 |
ARB | 27 (16.98%) | 199 (23.86%) | 0.0579 |
ACEI | 4 (2.52%) | 49 (5.88%) | 0.0841 |
Beta-blocker | 7 (4.4%) | 53 (6.35%) | 0.3437 |
CCB | 39 (24.53%) | 524 (62.83%) | <0.0001 |
Thiazide diuretic | 9 (5.66%) | 127 (15.23%) | 0.0013 |
Other | 14 (8.81%) | 80 (9.59%) | 0.756 |
NSAID | 12 (7.55%) | 191 (22.9%) | <0.0001 |
Steroid | 4 (2.52%) | 82 (9.83%) | 0.0026 |
H2 blocker | 17 (10.69%) | 455 (54.56%) | <0.0001 |
Proton pump inhibitor | 19 (11.95%) | 151 (18.11%) | 0.059 |
Antiepileptic drug | 2 (1.26%) | 55 (6.59%) | 0.008 |
Immunosuppressive drug | 0 (0%) | 18 (2.16%) | 0.0616 |
Diuretic | 8 (5.03%) | 129 (15.47%) | 0.0005 |
Antiarrhythmic drug | 12 (7.55%) | 104 (12.47%) | 0.0765 |
Results
Laboratory test | Clopidogrel plus aspirin (n = 159) | Aspirin alone (n = 834) | p |
---|---|---|---|
mean (95% CI) | mean (95% CI) | ||
Creatinine (mg/dl) | 0.93 (0.72, 1.14) | 1.12 (1.03, 1.22) | 0.0853 |
ALT (U/L) | 35.33 (33.15, 37.52) | 36.47 (35.52, 37.42) | 0.3490 |
AST (U/L) | 35.14 (32.96, 37.32) | 36.56 (35.61, 37.51) | 0.2409 |
WBC (103/μL) | 6.96 (6.30, 7.61) | 6.99 (6.74, 7.25) | 0.9210 |
RBC (106/μL) | 4.16 (4.06, 4.270) | 4.07 (4.02, 4.12) | 0.1177 |
PLT (103/μL) | 222.5 (205.3, 239.6) | 239.9 (232.4, 247.4) | 0.0675 |
Hemoglobin (g/dL) | 13.14 (12.81, 13.47) | 12.76 (12.61, 12.90) | 0.0369 |
Hematocrit (%) | 38.84 (37.89, 39.80) | 37.87 (37.45, 38.29) | 0.0664 |
Laboratory test | Clopidogrel plus aspirin (n = 159) | Aspirin alone (n = 834) | p |
---|---|---|---|
mean (95% CI) | mean (95% CI) | ||
Δ WBC (10
3
/μL) | |||
Unadjusted | −1.65 (−2.099, -1.202) | −0.455 (−0.651, -0.259) | <0.0001* |
Propensity adjustment | −1.509 (−1.999, -1.018) | −0.312 (−0.803, 0.179) | 0.0008* |
Multivariate model | −1.832 (−2.317, -1.346) | −0.435 (−0.634, 0.237) | <0.0001* |
Hemorrhagic event | Clopidogrel plus aspirin (n = 159) | Aspirin alone (n = 834) | Propensity adjustment | Multivariate model | ||
---|---|---|---|---|---|---|
no. (%) | Relative risk (95% CI) | P | Relative risk (95% CI) | P | ||
Intracranial hemorrhage | 5 (3.14%) | 17 (2.04%) | 1.71 (0.99, 2.94) | 0.0507 | 1.23 (0.76, 2.01) | 0.4009 |
Gastrointestinal bleeding | 5 (3.14%) | 6 (0.72%) | 2.61 (1.18, 5.80) | 0.0184 | 2.06 (1.02, 4.13) | 0.0430 |