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05.02.2016 | Original Contribution

Dietary and lifestyle determinants of acrylamide and glycidamide hemoglobin adducts in non-smoking postmenopausal women from the EPIC cohort

verfasst von: Mireia Obón-Santacana, Leila Lujan-Barroso, Heinz Freisling, Claire Cadeau, Guy Fagherazzi, Marie-Christine Boutron-Ruault, Rudolf Kaaks, Renée T. Fortner, Heiner Boeing, J. Ramón Quirós, Esther Molina-Montes, Saioa Chamosa, José María Huerta Castaño, Eva Ardanaz, Kay-Tee Khaw, Nick Wareham, Tim Key, Antonia Trichopoulou, Pagona Lagiou, Androniki Naska, Domenico Palli, Sara Grioni, Rosario Tumino, Paolo Vineis, Maria Santucci De Magistris, H. B. Bueno-de-Mesquita, Petra H. Peeters, Maria Wennberg, Ingvar A. Bergdahl, Hubert Vesper, Elio Riboli, Eric J. Duell

Erschienen in: European Journal of Nutrition | Ausgabe 3/2017

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Abstract

Purpose

Acrylamide was classified as ‘probably carcinogenic’ to humans in 1994 by the International Agency for Research on Cancer. In 2002, public health concern increased when acrylamide was identified in starchy, plant-based foods, processed at high temperatures. The purpose of this study was to identify which food groups and lifestyle variables were determinants of hemoglobin adduct concentrations of acrylamide (HbAA) and glycidamide (HbGA) in 801 non-smoking postmenopausal women from eight countries in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.

Methods

Biomarkers of internal exposure were measured in red blood cells (collected at baseline) by high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS) . In this cross-sectional analysis, four dependent variables were evaluated: HbAA, HbGA, sum of total adducts (HbAA + HbGA), and their ratio (HbGA/HbAA). Simple and multiple regression analyses were used to identify determinants of the four outcome variables. All dependent variables (except HbGA/HbAA) and all independent variables were log-transformed (log₂) to improve normality. Median (25th–75th percentile) HbAA and HbGA adduct levels were 41.3 (32.8–53.1) pmol/g Hb and 34.2 (25.4–46.9) pmol/g Hb, respectively.

Results

The main food group determinants of HbAA, HbGA, and HbAA + HbGA were biscuits, crackers, and dry cakes. Alcohol intake and body mass index were identified as the principal determinants of HbGA/HbAA. The total percent variation in HbAA, HbGA, HbAA + HbGA, and HbGA/HbAA explained in this study was 30, 26, 29, and 13 %, respectively.

Conclusions

Dietary and lifestyle factors explain a moderate proportion of acrylamide adduct variation in non-smoking postmenopausal women from the EPIC cohort.

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Titel: Dietary and lifestyle determinants of acrylamide and glycidamide hemoglobin adducts in non-smoking postmenopausal women from the EPIC cohort
verfasst von: Mireia Obón-Santacana
Leila Lujan-Barroso
Heinz Freisling
Claire Cadeau
Guy Fagherazzi
Marie-Christine Boutron-Ruault
Rudolf Kaaks
Renée T. Fortner
Heiner Boeing
J. Ramón Quirós
Esther Molina-Montes
Saioa Chamosa
José María Huerta Castaño
Eva Ardanaz
Kay-Tee Khaw
Nick Wareham
Tim Key
Antonia Trichopoulou
Pagona Lagiou
Androniki Naska
Domenico Palli
Sara Grioni
Rosario Tumino
Paolo Vineis
Maria Santucci De Magistris
H. B. Bueno-de-Mesquita
Petra H. Peeters
Maria Wennberg
Ingvar A. Bergdahl
Hubert Vesper
Elio Riboli
Eric J. Duell
Publikationsdatum: 05.02.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 3/2017
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-016-1165-5

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