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13.06.2019 | Original Contribution

Effects of a formula with a probiotic Bifidobacterium lactis Supplement on the gut microbiota of low birth weight infants

verfasst von: Cheng Chi, Yong Xue, Ruixia Liu, Yanxin Wang, Na Lv, Huihui Zeng, Nicholas Buys, Baoli Zhu, Jing Sun, Chenghong Yin

Erschienen in: European Journal of Nutrition | Ausgabe 4/2020

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Abstract

Purpose

Low birth weight (LBW) infants have a less diverse gut microbiota, enriched in potential pathogens, which places them at high risk of systemic inflammation diseases. This study aimed to identify the differences in gut bacterial community structure between LBW infants who received probiotics and LBW infants who did not receive probiotics.

Methods

Forty-one infants were allocated to the non-probiotic group (N group) and 56 infants to the probiotic group (P group), according to whether the formula they received contained a probiotic Bifidobacterium lactis. Gut bacterial composition was identified with sequencing of the 16S rRNA gene in fecal samples collected at 14 days after birth.

Results

There was no significant difference between the alpha diversity of the two groups, while the beta diversity was significantly different (p < 0.05). Our results showed that Bifidobacterium and Lactobacillus (both p < 0.05) were enriched in the P group, while Veillonella, Dolosigranulum and Clostridium sensu stricto 1 (all p < 0.05) were enriched in the N group. Predicted metagenome function analysis revealed enhancement of fatty acids, peroxisome, starch, alanine, tyrosine and peroxisome pathways in the P group, and enhancement of plant pathogen, Salmonella and Helicobacter pylori infection pathways in the N group.

Conclusions

Probiotic supplement in formula may affect the composition, stability and function of LBW infants’ gut microbiota. LBW infants who receive probiotic intervention may benefit from gut microbiota that contains more beneficial bacteria.

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Titel: Effects of a formula with a probiotic Bifidobacterium lactis Supplement on the gut microbiota of low birth weight infants
verfasst von: Cheng Chi
Yong Xue
Ruixia Liu
Yanxin Wang
Na Lv
Huihui Zeng
Nicholas Buys
Baoli Zhu
Jing Sun
Chenghong Yin
Publikationsdatum: 13.06.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 4/2020
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-019-02006-4

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Effects of a formula with a probiotic Bifidobacterium lactis Supplement on the gut microbiota of low birth weight infants