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Erschienen in:

2018 | OriginalPaper | Buchkapitel

9. Endokrines System

verfasst von : Erich Roth, Katharina Flich, Johannes Huber

Erschienen in: Molekulare Sport- und Leistungsphysiologie

Verlag: Springer Vienna

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Zusammenfassung

Die Bedeutung des endokrinen Systems bei sportlicher Betätigung beruht einerseits auf den Veränderungen systemischer Hormonkonzentrationen, welche von Art und Dauer der Belastung abhängig sind, andererseits an deren daraus resultierenden Wirkungen auf verschiedene Stoffwechselprozesse, welche für die Realisierung einer Leistung verantwortlich sind. Bildung und Freisetzung von Hormonen ist durch verschiedene Regelkreise determiniert und unterliegen oftmals einer neuronalen Kontrolle. Die Wirkung der Hormone basiert auf der Vermittlung chemischer Signale, die an den entsprechenden Zellen der Zielorgane über Rezeptoren aufgenommen werden. Wachstum, Entwicklung, Leistungsbereitschaft und Adaptierungsfähigkeit sowie der Alterungsprozess werden damit gesteuert. Dabei ist hervorzuheben, dass sich bei Frauen und Männern bei gleichen physiologischen Mechanismen Wirkungsmechanismen manifestieren können. Im zweiten Teil wird auf die wichtigsten Regelkreise des weiblichen Körpers eingegangen, welche neben ihrer Aufgabe für die Reproduktion in die körperliche und damit in die sportliche Leistungsfähigkeit der Frau eingreifen.

[1]

Hershberger MVE, S, von Eckardstein A (2009) Hormone, in Biochemie und Molekularbiologie des Menschen, M. Schartl, Gessler, M, V. Eckardstein, A., Editor. Urban und Fischer: München. p. 688–745

[2]

Sadava D.e.a. (2012) Hormone der Tiere, in Purves Biologie, Sadava D., Orians, G., Heller, H.C., Hillis, D., Berenbaum, M.R., Markl, J., Editor. Spektrum Akademischer Verlag: Heidelberg

[3]

Frayn KN (2010) Metabolic Regulation. A Human Perspective. 3 ed., Oxford: Wiley-Blackwell

[4]

Deutzmann R (2010) Hormonale Regulation, in Physiologie, J.C. Behrends, Bischofberger, J., Deutzmann, R., Editor. Georg Thieme Verlag. p. 830

[5]

Lang F, Lang P (2007) Basiswissen Physiologie. 2 ed. Heidelberg: Springer Medizin Verlag

[6]

Schartl M, Gessler M, von Eckardstein A (2009) Biochemie und Molekularbiologie des Menschen. München: Urban und Fischer

[7]

Brooks CL (2012) Molecular mechanisms of prolactin and its receptor. Endocr Rev. 33(4): p. 504–25

[8]

Herrington J, Carter-Su C (2001) Signaling pathways activated by the growth hormone receptor. Trends Endocrinol Metab. 12(6): p. 252–7CrossRefPubMed

[9]

Rotwein P (2012) Mapping the growth hormone – Stat5b – IGF-I transcriptional circuit. Trends Endocrinol Metab. 23(4): p. 186–93CrossRefPubMedPubMedCentral

[10]

Carter-Su C, Schwartz J, Smit LS (1996) Molecular mechanism of growth hormone action. Annu Rev Physiol. 58: p. 187–207CrossRefPubMed

[11]

Birzniece V, Nelson Ho KK (2011) Growth hormone and physical performance. Trends Endocrinol Metab. 22(5): p. 171–8CrossRefPubMed

[12]

Velders M, Diel P (2013) How sex hormones promote skeletal muscle regeneration. Sports Med. 43(11): p. 1089–100CrossRefPubMed

[13]

Taaffe DR et al. (2005) The effect of hormone replacement therapy and/or exercise on skeletal muscle attenuation in postmenopausal women: a yearlong intervention. Clin Physiol Funct Imaging. 25(5): p. 297–304CrossRefPubMed

[14]

MacNeil LG et al. (2011) 17beta-estradiol attenuates exercise-induced neutrophil infiltration in men. Am J Physiol Regul Integr Comp Physiol. 300(6): p. R1443–51CrossRef

[15]

Dalton JT et al. (2011) The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial. J Cachexia Sarcopenia Muscle. 2(3): p. 153–161CrossRefPubMedPubMedCentral

[16]

Hansen D et al. (2012) Effect of acute endurance and resistance exercise on endocrine hormones directly related to lipolysis and skeletal muscle protein synthesis in adult individuals with obesity. Sports Med. 42(5): p. 415–31CrossRefPubMed

[17]

Lancha A, Fruhbeck G, Gomez-Ambrosi J (2012) Peripheral signalling involved in energy homeostasis control. Nutr Res Rev. 25(2): p. 223–48CrossRefPubMed

[18]

Kraemer RR, Castracane VD (2007) Exercise and humoral mediators of peripheral energy balance: ghrelin and adiponectin. Exp Biol Med (Maywood). 232(2): p. 184–94

[19]

Bouassida A et al. (2010) Review on leptin and adiponectin responses and adaptations to acute and chronic exercise. Br J Sports Med. 44(9): p. 620–30CrossRefPubMed

[20]

Fragala MS et al. (2011) Neuroendocrine-immune interactions and responses to exercise. Sports Med. 41(8): p. 621–39CrossRefPubMed

[21]

Fuqua JS, Rogol AD (2013) Neuroendocrine alterations in the exercising human: implications for energy homeostasis. Metabolism. 62(7): p. 911–21CrossRefPubMed

[22]

Kraemer WJ, Ratamess NA (2005) Hormonal responses and adaptations to resistance exercise and training. Sports Med. 35(4): p. 339–61CrossRefPubMed

[23]

Meckel Y. et al. (2011) Hormonal and inflammatory responses to different types of sprint interval training. J Strength Cond Res. 25(8): p. 2161–9CrossRefPubMed

[24]

Vingren JL et al. (2010) Testosterone physiology in resistance exercise and training: the up-stream regulatory elements. Sports Med. 40(12): p. 1037–53CrossRefPubMed

[25]

Kraemer WJ et al. (1991) Endogenous anabolic hormonal and growth factor responses to heavy resistance exercise in males and females. Int J Sports Med. 12(2): p. 228–35CrossRefPubMed

[26]

Schumann M et al. (2013) Acute neuromuscular and endocrine responses and recovery to single-session combined endurance and strength loadings: "order effect" in untrained young men. J Strength Cond Res. 27(2): p. 421–33CrossRefPubMed

[27]

Kraemer WJ et al. (1989) Training responses of plasma beta-endorphin, adrenocorticotropin, and cortisol. Med Sci Sports Exerc. 21(2): p. 146–53CrossRefPubMed

[28]

Amelink GJ. et al. (1990) Sex-linked variation in creatine kinase release, and its dependence on oestradiol, can be demonstrated in an in-vitro rat skeletal muscle preparation. Acta Physiol Scand. 138(2): p. 115–24CrossRefPubMed

[29]

Kraemer RR, Francois M, Castracane VD (2012) Estrogen mediation of hormone responses to exercise. Metabolism. 61(10): p. 1337–46CrossRefPubMed

[30]

Hackney AC et al. (2012) Thyroid hormonal responses to intensive interval versus steady-state endurance exercise sessions. Hormones (Athens). 11(1): p. 54–60

[31]

Meeusen R et al. (2013) Prevention, diagnosis, and treatment of the overtraining syndrome: joint consensus statement of the European College of Sport Science and the American College of Sports Medicine. Med Sci Sports Exerc. 45(1): p. 186–205CrossRefPubMed

[32]

Urhausen A, Gabriel H, Kindermann W (1995) Blood hormones as markers of training stress and overtraining. Sports Med. 20(4): p. 251–76CrossRefPubMed

[33]

Brooks K, Carter J (2013) Overtraining, Exercise, and Adrenal Insufficiency. J Nov Physiother. 3(125)

[34]

Mullis PE (2010) Hormones and the science of athletic performance. Preface. Endocrinol Metab Clin North Am. 39(1): p. xviiCrossRefPubMed

[35]

Thieme DH (2010) Doping in Sports: Biochemical Principles, Effects and Analysis. Handbook of Experimental Pharmacology, ed. F.B. Hofmann. Vol. 195. Berlin Heidelberg: Springer

[36]

Baumann GP (2012) Growth hormone doping in sports: a critical review of use and detection strategies. Endocr Rev. 33(2): p. 155–86CrossRefPubMed

[37]

Mosler S et al. (2013) Modulation of follistatin and myostatin propeptide by anabolic steroids and gender. Int J Sports Med. 34(7): p. 567–72CrossRefPubMed

[38]

Koshland DE Jr. (1992) The molecule of the year. Science. 258(5090): p. 1861CrossRefPubMed

[39]

Allen JD et al. (2010) Plasma nitrite flux predicts exercise performance in peripheral arterial disease after 3months of exercise training. Free Radic Biol Med. 49(6): p. 1138–44CrossRefPubMedPubMedCentral

[40]

Sessa F et al. (2011) Gene polymorphisms and sport attitude in Italian athletes. Genet Test Mol Biomarkers. 15(4): p. 285–90CrossRefPubMed

[41]

Chambliss KL, Shaul PW (2002) Estrogen modulation of endothelial nitric oxide synthase. Endocr Rev. 23(5): p. 665–86CrossRefPubMed

[42]

Totzeck M et al. (2012) Higher endogenous nitrite levels are associated with superior exercise capacity in highly trained athletes. Nitric Oxide. 27(2): p. 75–81CrossRefPubMed

[43]

Suhr F et al. (2013) Skeletal Muscle Function during Exercise-Fine-Tuning of Diverse Subsystems by Nitric Oxide. Int J Mol Sci. 14(4): p. 7109–39CrossRefPubMedPubMedCentral

[44]

Haefliger IO et al. (1999) Potential role of nitric oxide and endothelin in the pathogenesis of glaucoma. Surv Ophthalmol. 43 Suppl 1: p. S51–8CrossRef

[45]

Chen Z et al. (1999) Estrogen receptor alpha mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen. J Clin Invest. 103(3): p. 401–6CrossRefPubMedPubMedCentral

[46]

Worda C et al. (2004) The influence of Nos3 polymorphisms on age at menarche and natural menopause. Maturitas. 49(2): p. 157–62CrossRefPubMed

[47]

Hefler LA et al. (2002) A polymorphism of the Nos3 gene and age at natural menopause. Fertil Steril. 78(6): p. 1184–6CrossRefPubMed

[48]

Stonek F et al. (2001) Calculated background elimination in quantifying nitric-oxide synthase enzyme activity. J Biochem Biophys Methods. 50(1): p. 29–32CrossRefPubMed

[49]

Puthucheary Z et al. (2011) The ACE gene and human performance: 12 years on. Sports Med. 41(6): p. 433–48CrossRefPubMed

[50]

Hefler LA et al. (2002) Polymorphisms of the angiotensinogen gene, the endothelial nitric oxide synthase gene, and the interleukin-1beta gene promoter in women with idiopathic recurrent miscarriage. Mol Hum Reprod. 8(1): p. 95–100CrossRefPubMed

[51]

Wang Z et al. (2013) Significant association between angiotensin-converting enzyme gene insertion/deletion polymorphism and risk of recurrent miscarriage: a systematic review and meta-analysis. Metabolism. 62(9): p. 1227–38CrossRefPubMed

[52]

Su MT et al. (2013) Genetic association studies of ACE and PAI-1 genes in women with recurrent pregnancy loss: a systematic review and meta-analysis. Thromb Haemost. 109(1): p. 8–15

[53]

Bernstein KE et al. (2013) A modern understanding of the traditional and nontraditional biological functions of angiotensin-converting enzyme. Pharmacol Rev. 65(1): p. 1–46

[54]

Montgomery HE et al. (1998) Human gene for physical performance. Nature. 393(6682): p. 221–2CrossRefPubMed

[55]

Myerson S et al. (1999) Human angiotensin I-converting enzyme gene and endurance performance. J Appl Physiol (1985). 87(4): p. 1313–6

[56]

Tsianos G et al. (2004) The ACE gene insertion/deletion polymorphism and elite endurance swimming. Eur J Appl Physiol. 92(3): p. 360–2CrossRefPubMed

[57]

Gayagay G. et al. (1998) Elite endurance athletes and the ACE I allele the role of genes in athletic performance. Hum Genet. 103(1): p. 48–50CrossRefPubMed

[58]

Alvarez R et al. (2000) Genetic variation in the renin-angiotensin system and athletic performance. Eur J Appl Physiol. 82(1-2): p. 117–20CrossRefPubMed

[59]

Collins M et al. (2004) The ACE gene and endurance performance during the South African Ironman Triathlons. Med Sci Sports Exerc. 36(8): p. 1314–20CrossRefPubMed

[60]

Woods D et al. (2001) Elite swimmers and the D allele of the ACE I/D polymorphism. Hum Genet. 108(3): p. 230–2CrossRefPubMed

[61]

Costa AM et al. (2009) Association between ACE D allele and elite short distance swimming. Eur J Appl Physiol. 106(6): p. 785–90CrossRefPubMed

[62]

Montgomery H, Dhamrait S (2002) ACE genotype and performance. J Appl Physiol (1985). 92(4): p. 1774–5; author reply 1776–7CrossRefPubMed

[63]

Woods DR, Humphries SE, Montgomery HE (2000) The ACE I/D polymorphism and human physical performance. Trends Endocrinol Metab. 11(10): p. 416–20CrossRefPubMed

[64]

Sonna LA et al. (2001) Angiotensin-converting enzyme genotype and physical performance during US Army basic training. J Appl Physiol (1985). 91(3): p. 1355–63PubMed

[65]

Karjalainen J et al. (1999) Angiotensinogen gene M235T polymorphism predicts left ventricular hypertrophy in endurance athletes. J Am Coll Cardiol. 34(2): p. 494–9CrossRefPubMed

[66]

Woods D et al. (2001) Angiotensin-I converting enzyme genotype-dependent benefit from hormone replacement therapy in isometric muscle strength and bone mineral density. J Clin Endocrinol Metab. 86(5): p. 2200–4PubMed

[67]

Komukai K, Mochizuki S, Yoshimura M (2010) Gender and the renin-angiotensin-aldosterone system. Fundam Clin Pharmacol. 24(6): p. 687–98CrossRefPubMed

[68]

Gonzalez-Cadavid NF, Bhasin S (2004) Role of myostatin in metabolism. Curr Opin Clin Nutr Metab Care. 7(4): p. 451–7CrossRefPubMed

[69]

Fischetto G, Bermon S (2013) From gene engineering to gene modulation and manipulation: can we prevent or detect gene doping in sports? Sports Med. 43(10): p. 965–77

[70]

Tsuchida K (2004) Activins, myostatin and related TGF-beta family members as novel therapeutic targets for endocrine, metabolic and immune disorders. Curr Drug Targets Immune Endocr Metabol Disord. 4(2): p. 157–66

[71]

Santiago C et al (2011) The K153R polymorphism in the myostatin gene and muscle power phenotypes in young, non-athletic men. PLoS ONE. 6(1): p. e16323CrossRef

[72]

Garatachea N et al. (2013) Association of the K153R polymorphism in the myostatin gene and extreme longevity. Age (Dordr). 35(6): p. 2445–54

[73]

Gonzalez-Freire M et al. (2010) The K153R variant in the myostatin gene and sarcopenia at the end of the human lifespan. Age (Dordr). 32(3): p. 405–9

[74]

Eynon N et al. (2013) Genes for elite power and sprint performance: ACTN3 leads the way. Sports Med. 43(9): p. 803–17CrossRefPubMed

[75]

Scott RA et al. (2010) ACTN3 and ACE genotypes in elite Jamaican and US sprinters. Med Sci Sports Exerc. 42(1): p. 107–12CrossRefPubMed

[76]

Eynon N et al. (2009) Is there an ACE ID – ACTN3 R577X polymorphisms interaction that influences sprint performance? Int J Sports Med. 30(12): p. 888–91CrossRefPubMed

[77]

Cieszczyk P, Sawczuk M, Maciejewska-Karlowska A, Ficek K (2012) ACTN3 R577X polymorphism in top-level Polish rowers. Journal of Exercise Science & Fitness. 10(1): p. 12–15CrossRef

[78]

Johannesson M, Ludviksdottir D, Janson C (2000) Lung function changes in relation to menstrual cycle in females with cystic fibrosis. Respir Med. 94(11): p. 1043–6CrossRefPubMed

[79]

Lanfranco F et al. (2010) Neuroendocrine alterations in obese patients with sleep apnea syndrome. Int J Endocrinol. 2010: p. 474518CrossRefPubMedPubMedCentral

[80]

Teran-Perez G et al. (2012) Steroid hormones and sleep regulation. Mini Rev Med Chem. 12(11): p. 1040–8CrossRefPubMed

[81]

Vos PJ et al. (1994) Effects of chlormadinone acetate, acetazolamide and oxygen on awake and asleep gas exchange in patients with chronic obstructive pulmonary disease (COPD). Eur Respir J. 7(5): p. 850–5PubMed

[82]

Hill M et al. (2014) Steroid profiling in pregnancy: a focus on the human fetus. J Steroid Biochem Mol Biol. 139: p. 201–22CrossRefPubMed

[83]

Blouin K, Boivin A, Tchernof A (2008) Androgens and body fat distribution. J Steroid Biochem Mol Biol. 108(3-5): p. 272–80CrossRefPubMed

[84]

Lee MJ et al. (2014) Deconstructing the roles of glucocorticoids in adipose tissue biology and the development of central obesity. Biochim Biophys Acta. 1842(3): p. 473–81CrossRefPubMed

[85]

Huber JC, Ott J (2009) The dialectic role of progesterone. Maturitas. 62(4): p. 326–9CrossRefPubMed

[86]

Gruber DM. et al. (1999) Progesterone and neurology. Gynecol Endocrinol. 13 Suppl 4: p. 41–5CrossRefPubMed

Titel: Endokrines System
verfasst von: Erich Roth
Katharina Flich
Johannes Huber
Verlag: Springer Vienna
Buch: Molekulare Sport- und Leistungsphysiologie
Print ISBN: 978-3-7091-1590-9

Electronic ISBN: 978-3-7091-1591-6

Copyright-Jahr: 2018
DOI: https://doi.org/10.1007/978-3-7091-1591-6_9

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