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Archives of Virology

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01.05.2024 | Brief Report

Genomic characterization of human respiratory syncytial virus circulating in Islamabad, Pakistan, during an outbreak in 2022-2023

verfasst von: Syed Adnan Haider, Zunera Jamal, Faheem Tahir, Muhammad Salman, Massab Umair

Erschienen in: Archives of Virology | Ausgabe 5/2024

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Abstract

In this study, conducted at the National Institute of Health, Islamabad, during an outbreak of human respiratory syncytial virus (hRSV) from December 2022 to January 2023, the first whole-genome sequences of hRSV isolates from Islamabad, Pakistan, were determined. Out of 10 positive samples, five were sequenced, revealing the presence of two genotypes: RSV-A (GA2.3.5, ON1 strain) and RSV-B (GB5.0.5.a, BA-10 strain). A rare non-synonymous substitution (E232G) in G the protein and N276S in the F protein were found in RSV-A. In RSV-B, the unique mutations K191R, Q209R, and I206M were found in the F protein. These mutations could potentially influence vaccine efficacy and viral pathogenicity. This research underscores the importance of genomic surveillance for understanding RSV diversity and guiding public health responses in Pakistan.

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Titel: Genomic characterization of human respiratory syncytial virus circulating in Islamabad, Pakistan, during an outbreak in 2022-2023
verfasst von: Syed Adnan Haider
Zunera Jamal
Faheem Tahir
Muhammad Salman
Massab Umair
Publikationsdatum: 01.05.2024
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 5/2024
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-024-06036-0

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