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Clinical Epileptology

Erschienen in:

01.11.2015 | Leitthema

Interactions between hormonal contraception and antiepileptic drugs in women with epilepsy

verfasst von: S. Deichmann, Ao. Univ. Prof. Dr. G. Luef, B. Rösing, L. Wildt

Erschienen in: Clinical Epileptology | Ausgabe 4/2015

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Abstract

The use of oral contraceptives (OCs) in combination with antiepileptic drugs (AEDs) in women with epilepsy (WWE) can lower efficiency both in terms of, for example, seizure deterioration and unintended pregnancies. We investigated the bidirectional interactions of progestins in OCs and monotherapy with lamotrigine (LTG), valproate (VPA) or carbamazepine (CBZ). The goal was to investigate the impact of these interactions in general and additionally to analyze differences in AED serum levels during intake.

We were able to demonstrate an inhibiting effect of AED serum levels on certain progestins which could increase seizure risks. Results of LTG serum levels varied on different progestins. Gestoden would be a good choice for WWE, because it does not seem to decrease LTG serum levels and is not reduced by LTG. Drospirenon, and presumably levonorgestrel, may increase seizure risks and lead to the risk of contraceptive failure due to their reduction and that of LTG.

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Titel: Interactions between hormonal contraception and antiepileptic drugs in women with epilepsy
verfasst von: S. Deichmann
Ao. Univ. Prof. Dr. G. Luef
B. Rösing
L. Wildt
Publikationsdatum: 01.11.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Epileptology / Ausgabe 4/2015
Print ISSN: 2948-104X
Elektronische ISSN: 2948-1058
DOI: https://doi.org/10.1007/s10309-015-0004-7

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