Ulcerative colitis (UC) is a chronic inflammatory bowel disease that typically results in inflammation and ulcers in the inner lining of the colon, often accompanied by symptoms such as diarrhea, abdominal pain, anemia, and weight loss. Some …
Obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) have been associated with an increased tonus of the endocannabinoid system (ECS) [ 1 , 2 ]. The ECS is composed of bioactive lipids named endocannabinoids which are …
verfasst von:
Larissa B. Fassarella, Jessika G. O. Neto, Juliana Woyames, Gustavo R. C. Santos, Henrique M. G. Pereira, Carmen C. Pazos-Moura, Isis H. Trevenzoli
Sickle cell disease (SCD) is an inherited hemoglobinopathy caused by a genetic mutation that leads to the substitution of glutamic acid with valine in the beta-globin chain of hemoglobin. This mutation results in the production of hemoglobin S (Hb …
verfasst von:
Juliana Omena¹, Flávia Fioruci Bezerra¹, Vanessa Monteiro Voll¹, Bernardo Ferreira Braz, Ricardo Erthal Santelli, Carmen Marino Donangelo, Gustavo Federico Jauregui, Andrea Soares Ribeiro, Cláudia dos Santos Cople Rodrigues, Marta Citelli
The prevalece of obesity has rearched alarming proportions. The World Obesity Federation reports that 104 million children (5–9 years of age) and 151 million adolescents (10–19 years of age) will be living with obesity by 2030 [ 1 , 2 ]. Danish …
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that affects millions of people worldwide and poses a substantial burden to human health and economy [ 1 , 2 ]. The global prevalence of diabetes in 2021 was estimated to be 10.5% (537 …
verfasst von:
Zhongyi Deng, Nina Wawro, Dennis Freuer, Annette Peters, Margit Heier, Christine Meisinger, Taylor A. Breuninger, Jakob Linseisen
Knee osteoarthritis (OA) is a chronic debilitating joint condition where articular cartilage degenerates over time, resulting in joint swelling, pain, loss of function, and reduced independence [ 1 ]. Knee OA can lead to progressive disability …
verfasst von:
Rafael Fortuna, Weilan Wang, Shyamchand Mayengbam, Erin W. Noye Tuplin, Kara Sampsell, Keith A. Sharkey, David A. Hart, Raylene A. Reimer
Mitochondria are membrane-bound cell organelles that produce most of the chemical energy in mammalian cells. The kidney is a highly energetic organ with abundant mitochondria since normal kidney function involves many energy-requiring processes …
verfasst von:
Jimin Park, Ki Heon Nam, Bo Young Nam, Gyuri Kim, Hyoungnae Kim, Ki Uk Lee, Seok Cheon Song, Tae-Wook Nam, Woon-Ki Kim, Jung Tak Park, Tae-Hyun Yoo, Shin-Wook Kang, GwangPyo Ko, Seung Hyeok Han
Self-reporting is a widely used approach in medical and social research to quantify exposure, resource use, or satisfaction [ 1 ]. Self-reporting is, in general, performed by asking participants to fill in a questionnaire or survey, or to respond …
verfasst von:
Nermine Laaboub, Setareh Ranjbar, Marie-Pierre F. Strippoli, Pedro Marques-Vidal, Sandrine Estoppey-Younes, Belen Ponte, Menno Pruijm, Bruno Vogt, Nicolas Ansermot, Séverine Crettol, Frederik Vandenberghe, Peter Vollenweider, Martin Preisig, Murielle Bochud, Chin B. EAP
Gastric cancer is the fifth-most common and fourth-most lethal cancer worldwide, with over 1 million new cases and 770,000 deaths in 2020 [ 1 ]. The highest age-standardised incident rates (ASIRs) for gastric cancer, calculated per 100,000 …
verfasst von:
Mayo Hirabayashi, Calistus Wilunda, Utako Murai, Taiki Yamaji, Motoki Iwasaki, Manami Inoue, Shoichiro Tsugane, Norie Sawada, for the JPHC Study Group
Metabolic syndrome (MetS) is characterized by high fasting plasma glucose, abdominal obesity, high blood pressure, low high-density lipoprotein cholesterol (HDL-C), and high serum triglyceride levels. The present MetS definition is inconsistent.
People with elevated Subjective Cognitive Failures (SCF), which are defined as the self-awareness of having brief failures in memory, perception, and/or action causing errors [ 1 , 2 ], may be indicative of an increased risk of developing dementia …
verfasst von:
Micah S. Adams, Ronald P. Mensink, Jogchum Plat, Peter J. Joris
Functional dyspepsia (FD), often referred to as “Shi Ji”, in traditional Chinese medicine is largely due to irrational eating behaviors and subsequent food retention in the gastrointestinal tract, thus affecting digestive function [ 1 ]. Nowadays …
An unbalanced diet such a diet with an insufficient intake of healthy food has become a public health problem in Japan. According to the National Health and Nutrition Survey in Japan, the intake of healthy food groups such as vegetables, fruits …
There is growing scientific interest in understanding how timing of food intake impacts health beyond quantity and quality of food intake [ 1 – 3 ]. Usually, variables of meal timing include time of first eating occasion, time of last eating …
verfasst von:
Yuchi Wu, Qi Nie, Yuqian Wang, Yuqin Liu, Weibo Liu, Tian Wang, Yaling Zhang, Sisi Cao, Zhengrong Li, Jianghong Zheng, Zichun Nie, Li Zhou
Poor diet quality has been considered as a risk factor for all-cause mortality, cardiovascular disease, cancer, and type 2 diabetes [ 1 ]. Although the Japanese diet is generally perceived as healthier than other diets [ 2 ], diet quality in Japan …
Omega-3 (ω-3) fatty acids, classified as polyunsaturated fatty acids (PUFAs), are identified by a double bond situated three atoms away from the terminal methyl group in their chemical structure [ 1 ]. Certain omega-3 fatty acids (FAs) like …
verfasst von:
Vida Rahimi, Elham Tavanai, Somayeh Falahzadeh, Ali Reza Ranjbar, Saeid Farahani
Constipation is a prevalent functional gastrointestinal disorder worldwide. According to the Rome III criteria for chronic constipation (CC) [ 1 ], nearly 16% of adults globally suffer from this condition [ 2 ]. Its hallmark features include …
Colorectal cancer (CRC) is the third most incident malignant tumor globally and ranks as the second leading cause of cancer-related mortality [ 1 ]. The number of new cases of CRC has seen a notable increase, rising from 842,098 in 1990 to 2.17 …
Gastric cancer (GC) is among the most commonly diagnosed cancers, and it is the 4th leading cause of cancer mortality globally [ 1 ]. In addition, GC has the highest incidence rates in East Asia, South America, and East Europe [ 2 ]. The risk …
verfasst von:
Giulia Collatuzzo, Jacqueline Cortez Lainez, Claudio Pelucchi, Eva Negri, Rossella Bonzi, Domenico Palli, Monica Ferraroni, Zuo-Feng Zhang, Guo-Pei Yu, Nuno Lunet, Samantha Morais, Lizbeth López-Carrillo, David Zaridze, Dmitry Maximovitch, Marcela Guevara, Vanessa Santos-Sanchez, Jesus Vioque, Manoli Garcia de la Hera, Mary H. Ward, Reza Malekzadeh, Mohammadreza Pakseresht, Raúl Ulises Hernández-Ramírez, Federica Turati, Charles S. Rabkin, Linda M. Liao, Rashmi Sinha, Malaquias López-Cervantes, Shoichiro Tsugane, Akihisa Hidaka, M. Constanza Camargo, Maria Paula Curado, Nadia Zubair, Dana Kristjansson, Shailja Shah, Carlo La Vecchia, Paolo Boffetta
