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Journal of Endocrinological Investigation OnlineFirst articles

Open Access 18.05.2024 | Original Article

The complexity of glucose time series is associated with short- and long-term mortality in critically ill adults: a multi-center, prospective, observational study

Over the past few years, the adoption of continuous glucose monitoring (CGM) has grown rapidly as a result of improvements in sensor accuracy, greater convenience and ease of use. Accumulating evidence suggest that the use of CGM has the potential …

verfasst von:
Y. Wang, S. Li, J. Lu, K. Feng, X. Huang, F. Hu, M. Sun, Y. Zou, Y. Li, W. Huang, J. Zhou

16.05.2024 | Original Article

TFCP2L1, a potential differentiation regulator, predicts favorable prognosis and dampens thyroid cancer progression

Thyroid cancer, the most prevalent type of human endocrine cancer, has shown a steeply increasing incidence during the past decades around the world. This cancer occurs much more frequently in women than in men [ 1 ]. Thyroid cancer can be …

verfasst von:
C. Zeng, Y. Zhang, C. Lin, W. Liang, J. Chen, Y. Chen, H. Xiao, Y. Li, H. Guan

Open Access 16.05.2024 | Original Article

Germline polymorphisms of the NOD2 pathway may predict the effectiveness of radioiodine in differentiated thyroid cancer treatment

Differentiated thyroid cancer (DTC) is the prevailing endocrine malignancy [ 1 ] and is predominantly treated with surgery and radioiodine [ 2 ]. Despite its generally promising clinical trajectory, patients presenting with distant metastases …

verfasst von:
M. Borowczyk, M. Kaczmarek-Ryś, S. Hryhorowicz, M. Sypniewski, D. Filipowicz, P. Dobosz, M. Oszywa, M. Ruchała, K. Ziemnicka

15.05.2024 | Original Article

HYPOXIA induces lncRNA HOTAIR for recruiting RELA in papillary thyroid cancer cells to upregulate miR-181a and promote angiogenesis

Thyroid carcinoma is the most common malignant tumor of the head and neck. It accounts for approximately 95% of all endocrine tumors, and poses a serious threat to human health [ 1 ]. Papillary thyroid carcinoma (PTC) is one of the most common …

verfasst von:
J. Lu, X. Liu, A. Cen, Y. Hong, Y. Wang

Open Access 14.05.2024 | Original Article

Correlation of serum DKK1 level with skeletal phenotype in children with osteogenesis imperfecta

Osteogenesis imperfecta (OI) is a rare monogenic hereditary osteopathy with an incidence of 1 in 15,000 to 20,000 live births, characterized by bone fragility and multiple bone fractures [ 1 ]. OI is caused by alteration in synthesis and …

verfasst von:
Y. Wang, J. Hu, L. Sun, B. Zhou, X. Lin, Q. Zhang, O. Wang, Y. Jiang, W. Xia, X. Xing, M. Li

11.05.2024 | Original Article

Sociodemographic profile, health-related behaviours and experiences of healthcare access in Italian transgender and gender diverse adult population

Transgender and gender diverse (TGD) people represent a broad spectrum of individuals whose gender identities differ from the recorded sex at birth [ 1 ]. The size of this population ranges, according to the most recent population-based studies …

verfasst von:
M. Marconi, M. T. Pagano, J. Ristori, S. Bonadonna, R. Pivonello, M. C. Meriggiola, G. Motta, F. Lombardo, M. Mosconi, A. Oppo, C. Cocchetti, A. Romani, S. Federici, L. Bruno, N. Verde, A. Lami, C. M. Crespi, L. Marinelli, L. Giordani, P. Matarrese, A. Ruocco, C. Santangelo, B. Contoli, M. Masocco, V. Minardi, F. Chiarotti, A. D. Fisher, M. Pierdominici

11.05.2024 | Original Article

Association of serum 25-hydroxyvitamin D with cardiovascular mortality and kidney outcome in patients with early stages of CKD

Chronic kidney disease (CKD) has been estimated to affect approximately 697.5 million individuals worldwide and to substantially increase their risk of end-stage kidney disease (ESKD) [ 1 ] Although the management of CKD has significantly improved …

verfasst von:
Y. Lin, C. Xie, Y. Zhang, F. Luo, Q. Gao, Y. Li, L. Su, R. Xu, X. Zhang, R. Chen, S. Zhou, P. Li, J. Liu, M. Liang, S. Nie, for the CRDS study Investigators

Open Access 10.05.2024 | Original Article

Sex and disease severity-based analysis of steroid hormones in ME/CFS

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisystem disease that primarily manifests as the inability to perform or participate in routine activities that were possible before the onset of the disease [ 1 ].

verfasst von:
Cornelia Pipper, Linda Bliem, Luis E. León, Daniela Mennickent, Claudia Bodner, Enrique Guzmán‑Gutiérrez, Michael Stingl, Eva Untersmayr, Bernhard Wagner, Romina Bertinat, Nuno Sepúlveda, Francisco Westermeier

Open Access 06.05.2024 | Original Article

Quantitative ultrasound techniques and biochemical markers to assess liver steatosis and fibrosis in newly diagnosed acromegaly

Acromegaly is a disease characterized by excessive secretion of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) [ 1 ]. While increased GH in acromegaly causes a decrease in total body fat by increasing lipolysis and lipid oxidation, it …

verfasst von:
M. Coskun, H. N. Sendur, A. Babayeva, M. N. Cerit, E. T. Cerit, M. M. Yalcin, A. E. Altinova, M. Akturk, M. A. Karakoc, F. B. Toruner

Open Access 04.05.2024 | Review

The use of telecytology for the evaluation of thyroid nodules fine-needle aspiration biopsy specimens: a systematic review

Thyroid nodules are a common finding among the general population [ 1 , 2 ]. Their prevalence has been estimated at around 4% if assessed via palpation, which is the least sensitive diagnostic method, and autopsy data from patients with no history …

verfasst von:
V. Oteri, S. Piane, E. Cocci

Open Access 02.05.2024 | Original Article

Improvement in clinical features of hypercortisolism during osilodrostat treatment: findings from the Phase III LINC 3 trial in Cushing's disease

Cushing’s disease, the most common form of endogenous Cushing’s syndrome, is a rare and debilitating condition caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary tumour, resulting in excessive secretion of cortisol from the …

verfasst von:
R. Pivonello, M. Fleseriu, J. Newell-Price, A. Shimatsu, R. A. Feelders, P. Kadioglu, A. Tabarin, T. C. Brue, E. B. Geer, A. Piacentini, A. M. Pedroncelli, B. M. K. Biller

Open Access 02.05.2024 | Original Article

A very-low-calorie ketogenic diet normalises obesity-related enhanced levels of erythropoietin compared with a low-calorie diet or bariatric surgery

Obesity is considered to be a persistent worldwide health epidemic. Despite advances in its management, the incidence of this disorder and its complications is still rising, suggesting that more attention should be focused on developing new …

verfasst von:
A. Fernandez-Pombo, P. M. Lorenzo, M. C. Carreira, D. Gomez-Arbelaez, A. I. Castro, D. Primo, J. Rodriguez, I. Sajoux, J. Baltar, D. de Luis, D. Bellido, A. B. Crujeiras, F. F. Casanueva

02.05.2024 | Original Article

FBXO28 reduces high-fat diet-induced hyperlipidemia in mice by alleviating abnormal lipid metabolism and inflammatory responses

Hyperlipidemia is a metabolic syndromes X disease caused by abnormal fat metabolism or transport, which has been a significant public health issue in recent years due to its increasing incidence and prevalence worldwide [ 1 ]. Hyperlipidemia …

verfasst von:
J. Sun, B. Du, M. Chen, J. Jia, X. Wang, J. Hong

02.05.2024 | Original Article

Regulation of iodine-glucose flip-flop in SW1736 anaplastic thyroid cancer cell line

The flip-flop phenomenon relates to the alternating manner of 131 I and fluorodeoxyglucose (FDG) uptake occurred in well-differentiated or poorly differentiated thyroid cancers [ 35 ]. Anaplastic thyroid cancer (ATC), as a dedifferentiated tumor …

verfasst von:
S. Heydarzadeh, A. A. Moshtaghie, M. Daneshpour, M. Hedayati

02.05.2024 | Original Article

Targeted therapy in BRAF mutated aggressive papillary craniopharyngioma: a case report and overview of the literature

Craniopharyngioma is a histologically benign (grade 1 according to the World Health Organization classification) tumor, which accounts for 2–5% of all primary intracranial neoplasms [ 1 ]. Despite the benign histology, craniopharyngioma often …

verfasst von:
M. Losa, E. Mazza, E. Pedone, G. Nocera, N. Liscia, M. Reni, P. Mortini

Open Access 29.04.2024 | Original Article

Improved overall survival in patients developing endocrine toxicity during treatment with nivolumab for advanced non-small cell lung cancer in a prospective study

Immune checkpoint inhibitors (ICPIs) have radically changed the history of a wide spectrum of different neoplasms, including both solid and hematologic tumors [ 1 – 3 ].

verfasst von:
M. Albertelli, G. Rossi, E. Nazzari, C. Genova, F. Biello, E. Rijavec, M. G. Dal Bello, L. Patti, M. Tagliamento, G. Barletta, P. Morabito, M. Boschetti, A. Dotto, D. Campana, D. Ferone, F. Grossi

Open Access 29.04.2024 | Original Article

Real-world use of oral versus subcutaneous semaglutide in a cohort of type 2 diabetic patients: which option to which patient?

Glucagon-like peptide-1 receptor agonists (GLP1-RAs) are an effective class of drugs for the treatment of type 2 diabetes mellitus (T2D), with well-defined safety and tolerability profiles. Their use is associated with better glycemic control and …

verfasst von:
C. Formichi, W. Baronti, G. de Gennaro, M. Cerrai Ceroni, L. Nigi, L. Rizzo, F. Dotta

Open Access 27.04.2024 | Endo&Art

Lack of hemochromatosis in Saint Augustine in his studio by Sandro Botticelli

verfasst von:
N. Kluger

25.04.2024 | Original Article

Mouse model of Graves’ orbitopathy induced by the immunization with TSHR A and IGF-1R α subunit gene

Graves’ disease (GD) is the most common type of autoimmune thyroid diseases [ 1 ]. Graves’ orbitopathy (GO) is the most common extrathyroidal GD manifestation, and 25–50% of GD patients develop GO, manifested as proptosis due to expansion of …

verfasst von:
R. Wu, N. Li, X. Wang, S. Wang, J. Tan, R. Wang, W. Zheng

22.04.2024 | Original Article

Preconceptional maternal hyperandrogenism and metabolic syndrome risk in male offspring: a long-term population-based study

One of the most significant causes of disability and mortality worldwide is cardiovascular diseases (CVDs), which are more prevalent in men than in women. Metabolic syndrome (MetS), a group of metabolic disorders, is considered a risk factor for …

verfasst von:
M. Noroozzadeh, M. Rahmati, M. Amiri, M. Saei Ghare Naz, F. Azizi, F. Ramezani Tehrani