Skip to main content
Erschienen in: Herzschrittmachertherapie + Elektrophysiologie 1/2011

01.03.2011 | Schwerpunkt

Kardiale Resynchronisationstherapie bei schmalem QRS-Komplex und gering beeinträchtigtem Leistungsvermögen

verfasst von: PD. Dr. M. Stockburger

Erschienen in: Herzschrittmachertherapie + Elektrophysiologie | Ausgabe 1/2011

Einloggen, um Zugang zu erhalten

Zusammenfassung

Die Kardiale Resynchronisationstherapie (CRT) mittels eines atriobiventrikulären Schrittmachersystems ist fest etabliert als Behandlungsoption für hochsymptomatische Patienten mit schwerer systolischer Herzinsuffizienz und verzögerter intraventrikulärer Leitung vom Linksschenkelblocktyp. Dieser Beitrag beleuchtet mögliche Anwendungsgebiete der biventrikulären Stimulation jenseits der klassischen CRT-Indikation. Insbesondere wird die verfügbare Information zur CRT bei Patienten mit schwerer systolischer Herzinsuffizienz, aber schmalem QRS-Komplex und bei solchen mit breitem QRS, aber weniger ausgeprägter oder fehlender Herzinsuffizienzsymptomatik zusammengefasst.
Literatur
1.
Zurück zum Zitat Abraham WT, Fisher WG, Smith AL et al (2002) Multicenter InSync Randomized Clinical Evaluation. Cardiac resynchronization in chronic heart failure. N Engl J Med 346:1845–1853PubMedCrossRef Abraham WT, Fisher WG, Smith AL et al (2002) Multicenter InSync Randomized Clinical Evaluation. Cardiac resynchronization in chronic heart failure. N Engl J Med 346:1845–1853PubMedCrossRef
2.
Zurück zum Zitat Achilli A, Sassara M, Ficili S et al (2003) Long-term effectiveness of cardiac resynchronization therapy in patients with refractory heart failure and „narrow“ QRS. J Am Coll Cardiol 42:2117–2124PubMedCrossRef Achilli A, Sassara M, Ficili S et al (2003) Long-term effectiveness of cardiac resynchronization therapy in patients with refractory heart failure and „narrow“ QRS. J Am Coll Cardiol 42:2117–2124PubMedCrossRef
3.
Zurück zum Zitat Aljaroudi W, Koneru J, Iqbal F et al (2010) Left ventricular mechanical dyssynchrony by phase analysis of gated single photon emission computed tomography in end-stage renal disease. Am J Cardiol 106H:1042–1047CrossRef Aljaroudi W, Koneru J, Iqbal F et al (2010) Left ventricular mechanical dyssynchrony by phase analysis of gated single photon emission computed tomography in end-stage renal disease. Am J Cardiol 106H:1042–1047CrossRef
4.
Zurück zum Zitat Auricchio A, Stellbrink C, Block M et al (1999) Effect of pacing chamber and atrioventricular delay on acute systolic function of paced patients with congestive heart failure. The Guidant Congestive Heart Failure Research Group. Circulation 99:2993–3001PubMed Auricchio A, Stellbrink C, Block M et al (1999) Effect of pacing chamber and atrioventricular delay on acute systolic function of paced patients with congestive heart failure. The Guidant Congestive Heart Failure Research Group. Circulation 99:2993–3001PubMed
5.
Zurück zum Zitat Baldasseroni S, Opasich C, Gorini M et al (2002) Left bundle-branch block is associated with increased 1-year sudden and total mortality rate in 5517 outpatients with congestive heart failure: A report from the Italian Network on Congestive Heart Failure. Am Heart J 143:398–405PubMedCrossRef Baldasseroni S, Opasich C, Gorini M et al (2002) Left bundle-branch block is associated with increased 1-year sudden and total mortality rate in 5517 outpatients with congestive heart failure: A report from the Italian Network on Congestive Heart Failure. Am Heart J 143:398–405PubMedCrossRef
6.
Zurück zum Zitat Barold SS, Ilercil A, Leonelli F, Herweg B (2006) First-degree atrioventricular block. Clinical manifestations, indications for pacing, pacemaker management & consequences during cardiac resynchronization. J Interv Card Electrophysiol 17:139–152PubMedCrossRef Barold SS, Ilercil A, Leonelli F, Herweg B (2006) First-degree atrioventricular block. Clinical manifestations, indications for pacing, pacemaker management & consequences during cardiac resynchronization. J Interv Card Electrophysiol 17:139–152PubMedCrossRef
7.
Zurück zum Zitat Basaran Y, Tigen K, Karaahmet T et al (2010) Fragmented QRS complexes are associated with cardiac fibrosis and significant intraventricular systolic dyssynchrony in nonischemic dilated cardiomyopathy patients with a narrow QRS interval. Echocardiography [Epub ahead of print] PMID: 20618390 Basaran Y, Tigen K, Karaahmet T et al (2010) Fragmented QRS complexes are associated with cardiac fibrosis and significant intraventricular systolic dyssynchrony in nonischemic dilated cardiomyopathy patients with a narrow QRS interval. Echocardiography [Epub ahead of print] PMID: 20618390
8.
Zurück zum Zitat Beshai JF, Grimm RA, Nagueh SF et al (2007) Cardiac-resynchronization therapy in heart failure with narrow QRS complexes. N Engl J Med 357:2461–2471PubMedCrossRef Beshai JF, Grimm RA, Nagueh SF et al (2007) Cardiac-resynchronization therapy in heart failure with narrow QRS complexes. N Engl J Med 357:2461–2471PubMedCrossRef
9.
Zurück zum Zitat Bleeker GB, Holman ER, Steendijk P et al (2006) Cardiac resynchronization therapy in patients with a narrow QRS complex. J Am Coll Cardiol 48:2243–2250PubMedCrossRef Bleeker GB, Holman ER, Steendijk P et al (2006) Cardiac resynchronization therapy in patients with a narrow QRS complex. J Am Coll Cardiol 48:2243–2250PubMedCrossRef
10.
Zurück zum Zitat Bristow MR, Saxon LA, Boehmer J et al (2004) Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. N Engl J Med 350:2140–2150PubMedCrossRef Bristow MR, Saxon LA, Boehmer J et al (2004) Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. N Engl J Med 350:2140–2150PubMedCrossRef
11.
Zurück zum Zitat Cazeau S, Ritter P, Bakdach S et al (1994) Four chamber pacing in dilated cardiomyopathy. Pacing Clin Electrophysiol 17(11 Pt 2):1974–1979PubMedCrossRef Cazeau S, Ritter P, Bakdach S et al (1994) Four chamber pacing in dilated cardiomyopathy. Pacing Clin Electrophysiol 17(11 Pt 2):1974–1979PubMedCrossRef
12.
Zurück zum Zitat Chung ES, Leon AR, Tavazzi L et al (2008) Results of the Predictors of Response to CRT (PROSPECT) trial. Circulation 117:2608–2616PubMedCrossRef Chung ES, Leon AR, Tavazzi L et al (2008) Results of the Predictors of Response to CRT (PROSPECT) trial. Circulation 117:2608–2616PubMedCrossRef
13.
Zurück zum Zitat Cleland JG, Daubert JC, Erdmann E et al (2005) The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med 352:1539–1549PubMedCrossRef Cleland JG, Daubert JC, Erdmann E et al (2005) The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med 352:1539–1549PubMedCrossRef
14.
Zurück zum Zitat D’Andrea A, Caso P, Cuomo S et al (2007) Effect of dynamic myocardial dyssynchrony on mitral regurgitation during supine bicycle exercise stress echocardiography in patients with idiopathic dilated cardiomyopathy and ‚narrow‘ QRS. Eur Heart J 28:1004–1011CrossRef D’Andrea A, Caso P, Cuomo S et al (2007) Effect of dynamic myocardial dyssynchrony on mitral regurgitation during supine bicycle exercise stress echocardiography in patients with idiopathic dilated cardiomyopathy and ‚narrow‘ QRS. Eur Heart J 28:1004–1011CrossRef
15.
Zurück zum Zitat Daubert C, Gold MR, Abraham WT et al (2009) Prevention of disease progression by cardiac resynchronization therapy in patients with asymptomatic or mildly symptomatic left ventricular dysfunction: insights from the European cohort of the REVERSE (Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction) trial. J Am Coll Cardiol 54(20):1837–1846PubMedCrossRef Daubert C, Gold MR, Abraham WT et al (2009) Prevention of disease progression by cardiac resynchronization therapy in patients with asymptomatic or mildly symptomatic left ventricular dysfunction: insights from the European cohort of the REVERSE (Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction) trial. J Am Coll Cardiol 54(20):1837–1846PubMedCrossRef
16.
Zurück zum Zitat De Teresa E, Chamorro JL, Pulpon LA (1983) An even more physiological pacing: Changing the sequence of ventricular activation. In: Steinbach K, Glogar D, Laszkovics A et al (Hrsg) Cardiac pacing. Proceedings of the VIIth World Symposium on Cardiac pacing. Steinkopff, Darmstadt, S 395–400 De Teresa E, Chamorro JL, Pulpon LA (1983) An even more physiological pacing: Changing the sequence of ventricular activation. In: Steinbach K, Glogar D, Laszkovics A et al (Hrsg) Cardiac pacing. Proceedings of the VIIth World Symposium on Cardiac pacing. Steinkopff, Darmstadt, S 395–400
17.
Zurück zum Zitat Dickstein K, Cohen-Solal A, Filippatos G et al (o J) ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur Heart J 29:2388–2442 Dickstein K, Cohen-Solal A, Filippatos G et al (o J) ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur Heart J 29:2388–2442
18.
Zurück zum Zitat Dickstein K, Vardas PE, Auricchio A et al (2010) 2010 Focused Update of ESC Guidelines on device therapy in heart failure: an update of the 2008 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure and the 2007 ESC guidelines for cardiac and resynchronization therapy. Developed with the special contribution of the Heart Failure Association and the European Heart Rhythm Association. Eur Heart J 31:2677–2687PubMedCrossRef Dickstein K, Vardas PE, Auricchio A et al (2010) 2010 Focused Update of ESC Guidelines on device therapy in heart failure: an update of the 2008 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure and the 2007 ESC guidelines for cardiac and resynchronization therapy. Developed with the special contribution of the Heart Failure Association and the European Heart Rhythm Association. Eur Heart J 31:2677–2687PubMedCrossRef
19.
Zurück zum Zitat Ghio S, Constantin C, Klersy C et al (2004) Interventricular and intraventricular dyssynchrony are common in heart failure patients, regardless of QRS duration. Eur Heart J 25:571–578PubMedCrossRef Ghio S, Constantin C, Klersy C et al (2004) Interventricular and intraventricular dyssynchrony are common in heart failure patients, regardless of QRS duration. Eur Heart J 25:571–578PubMedCrossRef
20.
Zurück zum Zitat Holzmeister J, Hürlimann D, Steffel J, Ruschitzka F (2009) Cardiac resynchronization therapy in patients with a narrow QRS. Curr Heart Fail Rep 6:49–56PubMedCrossRef Holzmeister J, Hürlimann D, Steffel J, Ruschitzka F (2009) Cardiac resynchronization therapy in patients with a narrow QRS. Curr Heart Fail Rep 6:49–56PubMedCrossRef
21.
Zurück zum Zitat Kindermann M, Hennen B, Jung J et al (2006) Biventricular versus conventional right ventricular stimulation for patients with standard pacing indication and left ventricular dysfunction: the Homburg Biventricular Pacing Evaluation (HOBIPACE). J Am Coll Cardiol 47:1927–1937PubMedCrossRef Kindermann M, Hennen B, Jung J et al (2006) Biventricular versus conventional right ventricular stimulation for patients with standard pacing indication and left ventricular dysfunction: the Homburg Biventricular Pacing Evaluation (HOBIPACE). J Am Coll Cardiol 47:1927–1937PubMedCrossRef
22.
Zurück zum Zitat Klemm HU, Krause KT, Ventura R et al (2010) Slow wall motion rather than electrical conduction delay underlies mechanical dyssynchrony in postinfarction patients with narrow QRS complex. J Cardiovasc Electrophysiol 21:70–77PubMedCrossRef Klemm HU, Krause KT, Ventura R et al (2010) Slow wall motion rather than electrical conduction delay underlies mechanical dyssynchrony in postinfarction patients with narrow QRS complex. J Cardiovasc Electrophysiol 21:70–77PubMedCrossRef
23.
Zurück zum Zitat Linde C, Abraham WT, Gold MR et al (2008) Randomized trial of cardiac resynchronization in mildly symptomatic heart failure patients and in asymptomatic patients with left ventricular dysfunction and previous heart failure symptoms. J Am Coll Cardiol 52:1834–1843PubMedCrossRef Linde C, Abraham WT, Gold MR et al (2008) Randomized trial of cardiac resynchronization in mildly symptomatic heart failure patients and in asymptomatic patients with left ventricular dysfunction and previous heart failure symptoms. J Am Coll Cardiol 52:1834–1843PubMedCrossRef
24.
Zurück zum Zitat Linde C, Braunschweig F, Gadler F et al (2003) Long-term improvements in quality of life by biventricular pacing in patients with chronic heart failure: results from the Multisite Stimulation in Cardiomyopathy study (MUSTIC). Am J Cardiol 91:1090–1095PubMedCrossRef Linde C, Braunschweig F, Gadler F et al (2003) Long-term improvements in quality of life by biventricular pacing in patients with chronic heart failure: results from the Multisite Stimulation in Cardiomyopathy study (MUSTIC). Am J Cardiol 91:1090–1095PubMedCrossRef
25.
Zurück zum Zitat Marcus GM, Rose E, Viloria EM et al (2005) Septal to posterior wall motion delay fails to predict reverse remodeling or clinical improvement in patients undergoing cardiac resynchronization therapy. J Am Coll Cardiol 46:2208–2214PubMedCrossRef Marcus GM, Rose E, Viloria EM et al (2005) Septal to posterior wall motion delay fails to predict reverse remodeling or clinical improvement in patients undergoing cardiac resynchronization therapy. J Am Coll Cardiol 46:2208–2214PubMedCrossRef
26.
Zurück zum Zitat McMurray JJ, Pfeffer MA (2005) Heart failure. Lancet 365:1877–1889. doi:10.1016/S0140-6736(05)66621-4PubMedCrossRef McMurray JJ, Pfeffer MA (2005) Heart failure. Lancet 365:1877–1889. doi:10.1016/S0140-6736(05)66621-4PubMedCrossRef
27.
Zurück zum Zitat Moss AJ, Hall WJ, Cannom DS et al (2009) Cardiac-resynchronization therapy for the prevention of heart-failure events. N Engl J Med 361:1329–1338PubMedCrossRef Moss AJ, Hall WJ, Cannom DS et al (2009) Cardiac-resynchronization therapy for the prevention of heart-failure events. N Engl J Med 361:1329–1338PubMedCrossRef
28.
Zurück zum Zitat Nelson GS, Berger RD, Fetics BJ et al (2000) Left ventricular or biventricular pacing improves cardiac function at diminished energy cost in patients with dilated cardiomyopathy and left bundle-branch block. Circulation;102:3053–3059 Nelson GS, Berger RD, Fetics BJ et al (2000) Left ventricular or biventricular pacing improves cardiac function at diminished energy cost in patients with dilated cardiomyopathy and left bundle-branch block. Circulation;102:3053–3059
29.
Zurück zum Zitat Stellbrink C, Auricchio A, Butter C et al (2000) Pacing Therapies in Congestive Heart Failure II study. Am J Cardiol 86:138K–143KPubMedCrossRef Stellbrink C, Auricchio A, Butter C et al (2000) Pacing Therapies in Congestive Heart Failure II study. Am J Cardiol 86:138K–143KPubMedCrossRef
30.
Zurück zum Zitat Stockburger M, Karhausen T, Müller E et al (2009) Predictors of extraordinarily favourable left ventricular reverse remodeling through long-term cardiac resynchronization. Europace 11(Suppl 2). doi:10.1093/europace/euq246 (abstract) Stockburger M, Karhausen T, Müller E et al (2009) Predictors of extraordinarily favourable left ventricular reverse remodeling through long-term cardiac resynchronization. Europace 11(Suppl 2). doi:10.1093/europace/euq246 (abstract)
31.
Zurück zum Zitat Stockburger M, Szabó T, Celebi Ö et al (2010) Baseline Body Composition Predicts Favourable Left Ventricular Remodeling Through Long-term Cardiac Resynchronisation. Europace 12(Suppl 1): i12 doi:10.1093/europace/euq127 (abstract)CrossRef Stockburger M, Szabó T, Celebi Ö et al (2010) Baseline Body Composition Predicts Favourable Left Ventricular Remodeling Through Long-term Cardiac Resynchronisation. Europace 12(Suppl 1): i12 doi:10.1093/europace/euq127 (abstract)CrossRef
32.
Zurück zum Zitat Tang AS, Wells GA, Talajic M et al (2010) Cardiac-resynchronization therapy for mild-to-moderate heart failure. N Engl J Med 363:2385–2395PubMedCrossRef Tang AS, Wells GA, Talajic M et al (2010) Cardiac-resynchronization therapy for mild-to-moderate heart failure. N Engl J Med 363:2385–2395PubMedCrossRef
33.
Zurück zum Zitat Bommel RJ van, Tanaka H, Delgado V et al (2010) Association of intraventricular mechanical dyssynchrony with response to cardiac resynchronization therapy in heart failure patients with a narrow QRS complex. Eur Heart J 31:3054–3062PubMedCrossRef Bommel RJ van, Tanaka H, Delgado V et al (2010) Association of intraventricular mechanical dyssynchrony with response to cardiac resynchronization therapy in heart failure patients with a narrow QRS complex. Eur Heart J 31:3054–3062PubMedCrossRef
34.
Zurück zum Zitat Yu CM, Chan YS, Zhang Q et al (2006) Benefits of cardiac resynchronization therapy for heart failure patients with narrow QRS complexes and coexisting systolic asynchrony by echocardiography. J Am Coll Cardiol 48:2251–2257PubMedCrossRef Yu CM, Chan YS, Zhang Q et al (2006) Benefits of cardiac resynchronization therapy for heart failure patients with narrow QRS complexes and coexisting systolic asynchrony by echocardiography. J Am Coll Cardiol 48:2251–2257PubMedCrossRef
Metadaten
Titel
Kardiale Resynchronisationstherapie bei schmalem QRS-Komplex und gering beeinträchtigtem Leistungsvermögen
verfasst von
PD. Dr. M. Stockburger
Publikationsdatum
01.03.2011
Verlag
Springer-Verlag
Erschienen in
Herzschrittmachertherapie + Elektrophysiologie / Ausgabe 1/2011
Print ISSN: 0938-7412
Elektronische ISSN: 1435-1544
DOI
https://doi.org/10.1007/s00399-011-0118-1

Weitere Artikel der Ausgabe 1/2011

Herzschrittmachertherapie + Elektrophysiologie 1/2011 Zur Ausgabe

Editorial

Editorial

Schadet Ärger den Gefäßen?

14.05.2024 Arteriosklerose Nachrichten

In einer Studie aus New York wirkte sich Ärger kurzfristig deutlich negativ auf die Endothelfunktion gesunder Probanden aus. Möglicherweise hat dies Einfluss auf die kardiovaskuläre Gesundheit.

Intervallfasten zur Regeneration des Herzmuskels?

14.05.2024 Herzinfarkt Nachrichten

Die Nahrungsaufnahme auf wenige Stunden am Tag zu beschränken, hat möglicherweise einen günstigen Einfluss auf die Prognose nach akutem ST-Hebungsinfarkt. Darauf deutet eine Studie an der Uniklinik in Halle an der Saale hin.

Shunt-Therapie bei Herzinsuffizienz: Kein Anzug, der allen passt

13.05.2024 Chronische Herzinsuffizienz Nachrichten

Die Anlage eines interatrialen Shunts zur Reduktion des linksatrialen Drucks ist ein neuer Therapieansatz bei Herzinsuffizienz. Viele Patienten sprechen darauf an, andere jedoch nicht. 

Vorsicht, erhöhte Blutungsgefahr nach PCI!

10.05.2024 Koronare Herzerkrankung Nachrichten

Nach PCI besteht ein erhöhtes Blutungsrisiko, wenn die Behandelten eine verminderte linksventrikuläre Ejektionsfraktion aufweisen. Das Risiko ist umso höher, je stärker die Pumpfunktion eingeschränkt ist.

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.