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European Archives of Psychiatry and Clinical Neuroscience

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01.02.2011 | Original Paper

A morphometric analysis of the septal nuclei in schizophrenia and affective disorders: reduced neuronal density in the lateral septal nucleus in bipolar disorder

verfasst von: Ralf Brisch, Hans-Gert Bernstein, Henrik Dobrowolny, Dieter Krell, Renate Stauch, Kurt Trübner, Johann Steiner, Mounir N. Ghabriel, Hendrik Bielau, Rainer Wolf, Jana Winter, Siegfried Kropf, Tomasz Gos, Bernhard Bogerts

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience | Ausgabe 1/2011

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Abstract

The septal nuclei are assumed to play a significant role in the pathophysiology of schizophrenia and affective disorders. The aim of this study was to morphometrically characterize the septal nuclei in patients with schizophrenia, bipolar disorder, and major depressive disorder, when compared with healthy control subjects. We analyzed the septal nuclei by determining the density and size of the neurons in postmortem brains in 17 patients with schizophrenia, 8 patients with bipolar disorder, 7 patients with major depressive disorder, and 14 control subjects matched for age and gender. There was a significant reduction in the neuronal density, but not in the mean cross-sectional area, in the lateral septal nucleus (P = 0.013) in patients with bipolar disorder when compared with control subjects. There were no significant changes in the neuronal density of the septal nuclei of the medial and lateral cell groups in patients with schizophrenia and major depressive disorder when compared with control subjects. There was a significant negative correlation between neuronal density in the lateral septal nucleus and disease duration in patients with major depressive disorder (P = 0.037, r = −0.9). The histopathological abnormality of the decreased neuronal density in the lateral septal nucleus, which is an important limbic region involved in emotions, might be a neuropathological correlate of bipolar disorder.

McNaughton N, Corr PJ (2004) A two-dimensional neuropsychology of defence: fear/anxiety and defensive distance. Neurosci Biobehav Rev 28:285–305CrossRefPubMed

Sheehan TP, Chambers RA, Russell DR (2004) Regulation of affect by the lateral septum: implications for neuropsychiatry. Brain Res Brain Res Rev 46:71–117CrossRefPubMed

Lubar JF, Numan R (1973) Behavioral and physiological studies on septal function and related medial cortical structures. Behav Biol 8:1–25CrossRefPubMed

Danner H, Pfister C (1981) Investigation on the cytoarchitecture of the nucleus accumbens septi of rat. Anat Anz 150:264–280PubMed

Smith KS, Berridge KC (2007) Opioid limbic circuit for reward: interaction between hedonic hotspots of nucleus accumbens and ventral pallidum. J Neurosci 27:1594–1605CrossRefPubMed

Kreczmanski P, Heinsen H, Mantua V, Woltersdorf F, Masson T, Ulfig N, Schmidt-Kastner R, Korr H, Steinbusch HWM, Hof PR, Schmitz C (2007) Volume, neuron density and total neuron number in five subcortical regions in schizophrenia. Brain 130:678–692CrossRefPubMed

Brady JV, Nauta WJH (1953) Subcortical mechanisms in emotional behaviour: affective changes following septal forebrain lesions in the albino rat. J Comp Physiol Psych 46:339–346CrossRef

Turgeon SM, Kegel G, Davis MM (2001) Electrolytic lesions of the medial septum enhance latent inhibition in a conditioned taste aversion paradigm. Brain Res 890:333–337CrossRefPubMed

van der Staay FJ, Bouger P, Lehmann O, Lazarus C, Cosquer B, Koenig J, Stump V, Cassel JC (2006) Long-term effects of immunotoxicy cholinergic lesions in the septum on acquisition of the cone-field task and noncognitive measures in rats. Hippocampus 16:1061–1079CrossRefPubMed

10.

Brockhaus H (1942) Zur feineren Anatomie des Septums und des Striatums. J Psychol Neurol 51:1–56

11.

Horvath S, Palkovits M (1987) Morphology of the human septal area: a topographic atlas. Acta Morphol Hung 35:157–174PubMed

12.

Andy OJ, Stephan H (1969) The septum in the human brain. J Comp Neurol 133:383–410CrossRef

13.

Ulfig N, Braack H (1989) Neuronal types and their percent distribution within the magnocellular nuclei of the human basal forebrain. Acta Anat 134:237–241CrossRefPubMed

14.

Zeman W, King FA (1958) Tumour of the septum pellucidum and adjacent structures with abnormal affective behavior: an anterior midline structure syndrome. J Nerv Ment Dis 127:490–502CrossRefPubMed

15.

Arendt T, Bigl V, Arendt A, Tennstedt A (1983) Loss of neurons in the nucleus basalis of Meynert in Alzheimer’s disease, paralysis agitans, and Korsakoff’s disease. Acta Neuropathol (Berl) 61:101–108CrossRef

16.

Averback P (1981) Structural lesions of the brain in young schizophrenics. Can J Neurol Sci 8:73–76PubMed

17.

Beck E, Gajdusek DC (1966) Variable size of the septal nuclei in man. Nature 210:1338–1340CrossRefPubMed

18.

Heath RG, Walker CF (1985) Correlation of deep and surface electroencephalograms with psychosis and hallucinations in schizophrenics: a report of two cases. Biol Psychiatry 20:669–674CrossRefPubMed

19.

Heath RG, Dempsey CW, Fontana CJ, Fitzjarelli AT (1980) Feedback loop between cerebellum and septo-hippocampal sites: its role in emotion and epilepsy. Biol Psychiatry 15:541–546PubMed

20.

Bogerts B (1997) The temporolimbic system theory of positive schizophrenic symptoms. Schizophr Bull 23:423–435PubMed

21.

Rajkowska G (2002) Cell pathology in mood disorder. Sem Clin Neuropsychiatry 7:281–292CrossRef

22.

Danos P, Baumann B, Krämer A, Bernstein H-G, Stauch R, Krell D, Falkai P, Bogerts B (2003) Volumes of association thalamic nuclei in schizophrenia: a postmortem study. Schizophr Res 60:141–155CrossRefPubMed

23.

Mai JK, Assheuer J, Paxinos G (1997) Atlas of the human brain. Academic Press Harcourt Brace & Company, San Diego, London, Boston, New York, Sydney, Tokyo, Toronto, pp 154–185

24.

Schumann CM, Amaral DG (2005) Stereological estimation of the number of neurons in the human amygdaloid complex. J Comp Neurol 491:320–329CrossRefPubMed

25.

Brisch R, Bernstein H-G, Krell D, Dobrowolny H, Bielau H, Steiner J, Gos T, Funke S, Stauch R, Knüppel S, Bogerts B (2009) Dopamine-glutamate abnormalities in the frontal cortex associated with the catechol-O-methyltransferase (COMT) in schizophrenia. Brain Res 1269:166–175CrossRefPubMed

26.

Gundersen HJ, Jensen EB, Kieu K, Nielsen J (1999) The efficiency of systematic sampling in stereology-reconsidered. J Microsc 151:3–21

27.

Brisch R, Bernstein H-G, Krell D, Stauch R, Dowbrowolny H, Trübner K, Kropf S, Bielau H, Bogerts B (2007) Volumetric analysis of septal region in schizophrenia and affective disorder. Eur Arch Psychiatry and Clin Neurosci 257:140–148CrossRef

28.

Beyer JL, Krishnan KRR (2002) Volumetric brain imaging findings in mood disorders. Bipolar Disord 4:89–104CrossRefPubMed

29.

Campbell S, MacQueen G (2006) An update on regional brain volume differences associated with mood disorders. Curr Opin Psychiatry 19:25–33CrossRefPubMed

30.

Takahashi T, Malhi GS, Wood SJ, Yücel M, Walterfang M, Nakamura K, Suzuki M, Pantelis C (2010) Midline brain abnormalities in established bipolar affective disorder. J Affect Disord 25:140–148

31.

Radenbach K, Flaig V, Schneider-Axmann T, Usher J, Reith W, Falkai P, Gruber O, Scherk H (2010) Thalamic volumes in patients with bipolar disorder. Eur Arch Psychiatry Clin Neurosci. doi:10.1007/s00406-010-0100-7

32.

Dahabra S, Ashton CH, Bahrainian M, Britton PG, Ferrier IN, McAllister VA, Marsh VR, Moore PB (1998) Structural and functional abnormalities in elderly patients clinically recovered from early- and late-onset depression. Biol Psychiatry 44:34–46CrossRefPubMed

33.

Sheline YI, Gado MH, Price JL (1998) Amygdala core nuclei are decreased in recurrent major depression. Neuroreport 9:2023–2027CrossRefPubMed

34.

Bremner JD, Narayan M, Anderson ER, Staib LH, Miller HL, Charney DS (2000) Hippocampal volume reduction in major depression. Am J Psychiatry 157:115–117CrossRefPubMed

35.

Frodl T, Meisenzahl EM, Zetsche T, Born C, Groll C, Jäger M, Leinsinger G, Bottlender R, Hahn K, Möller H-J (2002) Hippocampal changes in patients with a first episode of major depression. Am J Psychiatry 159:1112–1118CrossRefPubMed

36.

Posener JA, Wang L, Price JL, Gado MH, Province MA, Miller MI, Babb CM, Csernansky JG (2003) High-dimensional mapping of the hippocampus in depression. Am J Psychiatry 160:83–89CrossRefPubMed

37.

Selemon LD, Rajkowska G (2003) Cellular pathology in the dorsolateral prefrontal cortex distinguishes schizophrenia from bipolar disorder. Curr Mol Med 3:427–438CrossRefPubMed

38.

Benes FM, Vincent SL, Todtenkopf M (2001) The density of pyramidal and nonpyramidal neurons in anterior cingulate cortex of schizophrenic and bipolar subjects. Biol Psychiatry 50:395–406CrossRefPubMed

39.

Todtenkopf MS, Vincent SL, Benes FM (2005) A cross-study meta-analysis and three- dimensional comparison of cell counting in the anterior cingulate cortex of schizophrenia and bipolar brain. Schizophr Res 73:79–89CrossRefPubMed

40.

Benes FM, Kwok EW, Vincent SL, Todtenkopf MS (1998) A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives. Biol Psychiatry 44:88–97CrossRefPubMed

41.

Bouras C, Kövari E, Hof PR, Riederer BM, Giannakopoulos P (2001) Anterior cingulate cortex pathology in schizophrenia and bipolar disorder. Acta Neuropathol 102:373–379PubMed

42.

Beretta S, Pantazopoulos H, Lange N (2007) Neuron numbers and volume of the amygdala in subjects diagnosed with bipolar disorder or schizophrenia. Biol Psychiatry 62:884–893CrossRef

43.

Chana G, Landau S, Beasley C, Everall IP, Cotter D (2003) Two-dimensional assessment of cytoarchitecture in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia: evidence for decreased neuronal somal size and increased density. Biol Psychiatry 53:1086–1098CrossRefPubMed

44.

Cotter D, Mackay D, Landau S, Kerwin R, Everall I (2001) Reduced glial cell density and neuronal size in the anterior cingulate cortex in major depressive disorder. Arch Gen Psychiatry 58:545–553CrossRefPubMed

45.

Cotter D, Mackay D, Frangou S, Hudson L, Landau S (2004) Cell density, cortical thickness in Heschl`s gyrus in schizophrenia, major depression, bipolar disorder. Br J Psychiatry 185:258–259CrossRefPubMed

46.

Öngür D, Drevets WC, Price JL (1998) Glial reduction in the subgenual prefrontal cortex in mood disorders. Proc Natl Acad Sci USA 95:13290–13295CrossRefPubMed

47.

Cotter D, Hudson L, Landau S (2005) Evidence for orbitofrontal pathology in bipolar disorder and major depression, but not in schizophrenia. Bipolar Disord 7:358–369CrossRefPubMed

48.

Liu L, Schulz CS, Lee S, Reutiman TJ, Fatemi SH (2007) Hippocampal CA1 pyramidal cell size is reduced in bipolar disorder. Cell Mol Neurobiol 27:351–358CrossRefPubMed

49.

Bezchlibnyk YB, Sun X, Wang J-F, MacQueen GM, McEwen BS, Young LT (2007) Neuron somal size is decreased in the lateral amygdalar nucleus of subjects with bipolar disorder. J Psychiatry Neurosci 32:203–210PubMed

50.

Young KA, Holcomb LA, Yazdani U, Hicks PB, German DC (2004) Elevated neuron number in the limbic thalamus in major depression. Am J Psychiatry 161:1270–1277CrossRefPubMed

51.

Stockmeier CA, Mahajan GJ, Konick LC, Overholser JC, Jurius GJ, Meltzer HY, Uylings HBM, Friedman L, Rajkowska G (2004) Cellular changes in the postmortem hippocampus in major depression. Biol Psychiatry 56:640–650CrossRefPubMed

52.

Amunts K, Zilles K (2007) Funktionelle Neuroanatomie. In: Schneider F, Fink GR (eds) Funktionelle MRT in Psychiatrie und Neurologie. Springer Medizin Verlag Heidelberg, 1, Auflage, pp 1–58

53.

Grossman SP (1977) An experimental dissection of the septal syndrome. Ciba Found Symp 58:227–273PubMed

54.

Martin MM, Horn KL, Kusman KJ, Wallace DG (2007) Medial septum lesions disrupt exploratory trip organization: evidence for septohippocampal involvement in dead reckoning. Physiol Behav 90:412–424CrossRefPubMed

55.

Cavazos JE, Wang C-J, Sitoh Y-Y, Ng SES, Tien RD (1997) Anatomy and pathology of the septal region. Neuroimaging Clin N Am 7:67–78PubMed

56.

Baumann B, Bielau H, Krell D, Agelink MW, Diekmann S, Wurthmann C, Trübner K, Bernstein H-G, Danos P, Bogerts B (2002) Circumscribed numerical deficit of dorsal raphe neurons in mood disorders. Psychol Med 32:93–103CrossRefPubMed

57.

Bernstein H-G, Stanarius A, Baumann B, Henning H, Krell D, Falkai P, Bogerts B (1998) Nitric oxide synthase-containing neurons in the human hypothalamus: reduced number of immunoreactive cells in the paraventricular nucleus of depressive patients and schizophrenics. Neuroscience 83:867–875CrossRefPubMed

58.

Baumann B, Bogerts B (2001) Neuroanatomical studies of bipolar disorder. Br J Psychiatry Suppl 178:s142–s147CrossRef

59.

Bernstein H-G, Heinemann A, Krell D, Mawrin C, Bielau H, Danos P, Diekmann S, Keilhoff G, Bogerts B, Baumann B (2002) Further immunohistochemical evidence for impaired NO signalling in the hypothalamus of depressed patients. Ann NY Acad Sci 973:91–93CrossRefPubMed

60.

Bielau H, Mawrin C, Krell D, Agelink MW, Trübner K, Davis R, Gos T, Bogerts B, Bernstein H-G, Baumann B (2005) Differences in activation of the dorsal raphe nucleus depending on performance of suicide. Brain Res 255:401–412

61.

Manaye KF, Lei D-L, Tizabi Y, Davila-Garcia MI, Mouton PR, Kelly PH (2005) Selective neuron loss in the paraventricular nucleus of hypothalamus in patients suffering from major depression and bipolar disorder. J Neuropathol Exp Neurol 64:224–229PubMed

62.

Ranft K, Dobrowolny H, Krell D, Bielau H, Bogerts B, Bernstein H-G (2010) Evidence for structural abnormalities of the human habenular complex in affective disorders but not in schizophrenia. Psychol Med 40:557–567CrossRefPubMed

63.

Watson S, Gallagher P, Ritchie JC, Ferrier N, Young AH (2004) Hypothalamic- pituitary-adrenal-axis function in patients with bipolar disorder. Br J Psychiatry 184:496–502CrossRefPubMed

64.

Daban C, Vieta E, Mackin P, Young AH (2005) Hypothalamic-pituitary-adrenal axis and bipolar disorder. Psychiatr Clin North Am 28:469–480CrossRefPubMed

65.

Jokinen J, Nordström P (2009) HPA axis hyperactivity and attempted suicide in young adult mood disorder patients. J Affect Disord 116:117–120CrossRefPubMed

66.

Pompili M, Serafini G, Innamorati M, Möller-Leimkühler AM, Giupponi G, Girardi P, Tatarelli R, Lester D (2010) The hypothalamic-pituitary-adrenal axis and serotonin abnormalities: a selective overview for the implications of suicide prevention. Eur Arch Psychiatry Clin Neurosci. doi:10.1007/s00406-010-0108-z

67.

Murakami S, Imbe H, Morikawa Y, Kuobo C, Senba E (2005) Chronic stress, as well as acute stress, reduces BDNF mRNA expression but less robustly. Neurosci Res 53:129–139CrossRefPubMed

68.

Das GD, Altman J (1970) Postnatal neurogenesis in the caudate nucleus and nucleus accumbens septi. Brain Res 21:122–127CrossRefPubMed

69.

Raisman G (1969) Neuronal plasticity in the septal nuclei of the adult rat. Brain Res 14:25–48CrossRefPubMed

70.

Steciuk M, Kram M, Kramer GL, Petty F (1999) Decrease in stress-induced c-Fos-like immunoreactivity in the lateral septal nucleus of learned helpless rats. Brain Res 822:256–259CrossRefPubMed

71.

Huang YH, Cheng C-Y, Hong C-J, Tsai SJ (2004) Expression of c-Fos-like immunoreactivity in the brain of mice with learned helplessness. Neurosci Lett 363:280–283CrossRefPubMed

72.

Zhang J-H, Pimenta AF, Levitt P, Zhou R (1997) Dynamic expression suggests multiple roles of the EPH family receptor brain-specific kinase (Bsk) during mouse neurogenesis. Mol Brain Res 47:202–214CrossRefPubMed

73.

Bernier PJ, Vinet J, Cossette M, Parent A (2000) Characterization of the sub ventricular zone of the adult human brain: evidence for the involvement of Bcl-2. Neurosci Res 37:67–78CrossRefPubMed

74.

Pencea V, Bingaman KD, Wiegand SJ, Luskin MB (2001) Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus. J Neurosci 21:6706–6717PubMed

75.

Wakade CG, Mahadik SP, Waller JL, Chiu FC (2002) Atypical neuroleptics stimulate neurogenesis in adult rat brain. J Neurosci Res 69:72–79CrossRefPubMed

76.

Kodama M, Fujioka T, Duman RS (2004) Chronic olanzapine or fluoxetine administration increases cell proliferation in hippocampus and prefrontal cortex of adult rat. Biol Psychiatry 56:570–580CrossRefPubMed

77.

Chen Z, Xu H, Haimano S, Li X, Li XM (2005) Quetiapine and venlafaxine synergically regulate heme oxygenase-2 protein expression in the hippocampus of stressed rats. Neurosci Lett 389:173–177CrossRefPubMed

78.

Luo C, Xu H, Li XM (2005) Quetiapine reverses the suppression of hippocampal neurogenesis caused by repeated restraint stress. Brain Res 1063:32–39CrossRefPubMed

79.

Csernansky JG, Martin MV, Czeisler B, Meltzer MA, Ali Z, Dong H (2006) Neuroprotective effects of olanzapine in a rat model of neurodevelopment injury. Pharmacol Biochem Behav 83:208–213CrossRefPubMed

80.

Xu H, Chen Z, He J, Haimanot S, Li X, Dyck L, Li XM (2006) Synergetic effects of quetiapine and venlafaxine in preventing the chronic restraint stress-induced decrease in cell proliferation and BDNF expression in rat hippocampus. Hippocampus 16:551–559CrossRefPubMed

81.

Weinberger DR (1987) Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry 44:660–669PubMed

82.

Lipska BK (2004) Using animal models to test a neurodevelopmental hypothesis of schizophrenia. J Psychiatry Neurosci 29:282–289PubMed

83.

Brisch R, Bernstein H-G, Stauch R, Dobrowolny H, Krell D, Truebner K, Meyer-Lotz G, Bielau H, Steiner J, Kropf S, Gos T, Danos P, Bogerts B (2008) The volumes of the fornix in schizophrenia and affective disorders: A post-mortem study. Psychiatry Res 164:265–273CrossRefPubMed

Titel: A morphometric analysis of the septal nuclei in schizophrenia and affective disorders: reduced neuronal density in the lateral septal nucleus in bipolar disorder
verfasst von: Ralf Brisch
Hans-Gert Bernstein
Henrik Dobrowolny
Dieter Krell
Renate Stauch
Kurt Trübner
Johann Steiner
Mounir N. Ghabriel
Hendrik Bielau
Rainer Wolf
Jana Winter
Siegfried Kropf
Tomasz Gos
Bernhard Bogerts
Publikationsdatum: 01.02.2011
Verlag: Springer-Verlag
Erschienen in: European Archives of Psychiatry and Clinical Neuroscience / Ausgabe 1/2011
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-010-0119-9

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