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Virchows Archiv

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01.12.2004 | Original Article

Expression of proteins related to prostaglandin E₂ biosynthesis is increased in human gastric cancer and during gastric carcinogenesis

verfasst von: Tae Jung Jang

Erschienen in: Virchows Archiv | Ausgabe 6/2004

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Abstract

Prostaglandin E₂ (PGE₂) is related to carcinogenesis. Cyclooxygenase (COX) and prostaglandin E synthase (PGES) are involved in PGE₂ synthesis. However, overall situation of COX and microsomal PGES (mPGES) expression in gastric cancer has not been studied in detail. The expression of COX and mPGES was evaluated in 45 cases of gastric cancer (22 intestinal type and 23 diffuse type), 13 gastric dysplasia, 15 intestinal metaplasia, 18 Helicobacter pylori associated gastritis, and 10 normal gastric tissues by performing immunohistochemistry and Western blot analysis. COX-1 expression was higher in intestinal type cancers than diffuse ones. COX-2 and mPGES-1 were expressed more in cancers than in paired nonneoplastic adjacent tissues, and intestinal type cancers showed higher expression of COX-2 than diffuse ones. The expression of COX and mPGES was gradually increased with progression of gastric lesions and the highest in dysplasia. mPGES-1 was expressed not only in epithelial cells but also in stromal cells, whose phenotype was myofibroblast, endothelial cells and others. In conclusion, proteins related to PGE₂ biosynthesis affect both histogenesis and the carcinogenesis of human gastric cancer.

Ashby B (1998) Co-expression of prostaglandin receptors with opposite effects: a model for homeostatic control of autocrine and paracrine signaling. Biochem Pharmacol 55:239–246CrossRefPubMed

Bottone FG Jr, Martinez JM, Alston-Mills B, Eling TE (2004) Gene modulation by Cox-1 and Cox-2 specific inhibitors in human colorectal carcinoma cancer cells. Carcinogenesis 25:349–357CrossRefPubMed

Chulada PC, Thompson MB, Mahler JF, Doyle CM, Gaul BW, Lee C, Tiano HF, Morham SG, Smithies O, Langenbach R (2000) Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice. Cancer Res 60:4705–4708PubMed

DeWitt DL (1991) Prostaglandin endoperoxide synthase: regulation of enzyme expression. Biochim Biophys Acta 1083:121–134CrossRefPubMed

Eberhart CE, DuBois RN (1995) Eicosanoids and gastrointestinal tract. Gastroenterology 109:285–301PubMed

Filion F, Bouchard N, Goff AK, Lussier JG, Sirois J (2001) Molecular cloning and induction of bovine prostaglandin E synthase by gonadotropins in ovarian follicles prior to ovulation in vivo. J Biol Chem 276:34323–34330CrossRefPubMed

Gupta RA, Tejada LV, Tong BJ, Das SK, Morrow JD, Dey SK, DuBois RN (2003) Cyclooxygenase-1 is overexpressed and promotes angiogenic growth factor production in ovarian cancer. Cancer Res 63:906–911PubMed

Hanahan D, Weinberg RA (2000) Hallmarks of cancer. Cell 100:57–70CrossRefPubMed

Jabbour HN, Milne SA, Williams AR, Anderson RA, Boddy SC (2001) Expression of COX-2 and PGE synthase and synthesis of PGE2 in endometrial adenocarcinoma: a possible autocrine/paracrine regulation of neoplastic cell function via EP₂/EP₄ receptors. Br J Cancer 85:1023–1031CrossRefPubMed

10.

Jang TJ, Jung HG, Jung KH, O MK (2002) Chemopreventive effect of celecoxib and expression of cyclooxygenase-1 and cyclooxygenase-2 on chemically-induced rat mammary tumours. Int J Exp Pathol 83:173–182CrossRefPubMed

11.

Jang TJ, Min SK, Bae JD, Jung KH, Lee JI, Kim JR, Ahn WS (2004) Expression of cyclooxygenase 2, microsomal prostaglandin E synthase 1, and EP receptors is increased in rat oesophageal squamous cell dysplasia and Barrett’s metaplasia induced by duodenal contents reflux. Gut 53:27–33CrossRefPubMed

12.

Jones MK, Wang H, Peskar BM, Levin E, Itani RM, Sarfeh IJ, Tarnawski AS (1999) Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing. Nat Med 5:1418–1423CrossRefPubMed

13.

Kamei D, Murakami M, Nakatani Y, Ishikawa Y, Ishii T, Kudo I (2003) Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis. J Biol Chem 278:19396–19405CrossRefPubMed

14.

Kitamura T, Kawamori T, Uchiya N, Itoh M, Noda T, Matsuura M, Sugimura T, Wakabayashi K (2002) Inhibitory effects of mofezolac, a cyclooxygenase-1 selective inhibitor, on intestinal carcinogenesis. Carcinogenesis 23:1463–1466CrossRefPubMed

15.

Lim HY, Joo HJ, Choi JH, Yang MS, Cho DY, Kim HS, Nam DK, Lee KB, Kim HC (2000) Increased expression of cyclooxygenase-2 protein in human gastric carcinoma. Clin Cancer Res 6:519–525PubMed

16.

Murakami M, Naraba H, Tanioka T, Semmyo N, Nakatani Y, Kojima F, Ikeda T, Fueki M, Ueno A, Oh S, Kudo I (2000) Regulation of prostaglandin E₂ biosynthesis by inducible membrane-associated prostaglandin E₂ synthase that acts in concert with cyclooxygenase-2. J Biol Chem 275:32783–32792CrossRefPubMed

17.

Murakami M, Nakatani Y, Tanioka T, Kudo I (2002) Prostaglandin E synthase. Prostaglandins Other Lipid Mediat 68-69:383–399

18.

Murakami M, Nakashima K, Kamei D, Masuda S, Ishikawa Y, Ishii T, Ohmiya Y, Watanabe K, Kudo I (2003) Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenase-1 and–2. J Biol Chem 278:37937–37947CrossRefPubMed

19.

Murata H, Kawano S, Tsuji S, Tsuji M, Sawaoka H, Kimura Y, Shiozaki H, Hori M (1999) Cyclooxygenase-2 overexpression enhances lymphatic invasion and metastasis in human gastric carcinoma. Am J Gastroenterol 94:451–455CrossRefPubMed

20.

Mutoh M, Watanabe K, Kitamura T, Shoji Y, Takahashi M, Kawamori T, Tani K, Kobayashi M, Maruyama T, Kobayashi K, Ohuchida S, Sugimoto Y, Narumiya S, Sugimura T, Wakabayashi K (2002) Involvement of prostaglandin E receptor subtype EP₄ in colon carcinogenesis. Cancer Res 62:28–32PubMed

21.

Nardone G, Rocco A, Vaira D, Staibano S, Budillon A, Tatangelo F, Sciulli MG, Perna F, Salvatore G, Di Benedetto M, De Rosa G, Patrignani P (2004) Expression of COX-2, mPGE-synthase1, MDR-1 (P-gp), and Bcl-xL: a molecular pathway of H pylori-related gastric carcinogenesis. J Pathol 202:305–312CrossRefPubMed

22.

Que FG, Gores J (1996) Cell death by apoptosis: basic concept and disease relevance for the gastroenterologist. Gastroenterology 110:1238–1243PubMed

23.

Rees BP van, Saukkonen K, Ristimaki A (2002) Cyclooxygenase-2 expression during carcinogenesis in human stomach. J Pathol 196:171–179CrossRefPubMed

24.

Rees BP van, Sivula A, Thoren S, Yokozaki H, Jakobsson PJ, Offerhaus GJ, Ristimaki A (2003) Expression of microsomal prostaglandin E synthase-1 in intestinal type gastric adenocarcinoma and in gastric cancer cell lines. Int J Cancer 107:551–556CrossRefPubMed

25.

Ristimäki A, Honkanen N, Jänkala H, Sipponen P, Härkönen M (1997) Expression of cyclooxygenase-2 in human gastric carcinoma. Cancer Res 57:1276–1280PubMed

26.

Romano M, Ricci V, Memoli A, Tuccillo C, Di Popolo A, Sommi P, Acquaviva AM, Del Vecchio Blanco C, Bruni CB, Zarrilli R (1998) Helicobacter pylori upregulates cyclooxygenase-2 mRNA expression and prostaglandin E2 synthesis in MKN 28 gastric mucosal cells in vitro. J Biol Chem 273:28560–28563CrossRefPubMed

27.

Satoh K, Nagano Y, Shimomura C, Suzuki N, Saeki Y, Yokota H (2000) Expression of prostaglandin E synthase mRNA is induced in beta-amyloid treated rat astrocytes. Neurosci Lett 283:221–223CrossRefPubMed

28.

Stichtenoth DO, Thoren S, Bian H, Peters-Golden M, Jakobsson PJ, Crofford LJ (2001) Microsomal prostaglandin E synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells. J Immunol 167:469–474. 14PubMed

29.

Sun Y, Tang XM, Half E, Kuo MT, Sinicrope FA (2002) Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells. Cancer Res 62:6323–6328PubMed

30.

Sung JJ, Leung WK, Go MY, To KF, Cheng AS, Ng EK, Chan FK (2000) Cyclooxygenase-2 expression in Helicobacter pylori-associated premalignant and malignant gastric lesions. Am J Pathol 157:729–735PubMed

31.

Tang X, Sun YJ, Half E, Kuo MT, Sinicrope FA (2002) Cyclooxygenase-2 overexpression inhibits death receptor 5 expression and confers resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human colon cancer cells. Cancer Res 62:4903–4908PubMed

32.

Tanikawa N, Ohmiya Y, Ohkubo H, Hashimoto K, Kangawa K, Kojima M, Ito S, Watanabe K (2002) Identification and characterization of a novel type of membrane-associated prostaglandin E synthase. Biochem Biophys Res Commun 291:884–889CrossRefPubMed

33.

Tanioka T, Nakatani Y, Semmyo N, Murakami M, Kudo I (2000) Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis. J Biol Chem 275:32775–32782CrossRefPubMed

34.

Tsujii M, DuBois RN (1995) Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell 83:493–501CrossRefPubMed

35.

Tsujii M, Kawano S, DuBois RN (1997) Cyclooxyenase-2 expression in human colon cancer cells increases metastatic potential. Proc Natl Acad Sci USA 94:3336–3340CrossRefPubMed

36.

Tsujii M, Kawano S, Tsuji S, Sawaoka H, Hori M, DuBois RN (1998) Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 93:705–716CrossRefPubMed

37.

Uefuji K, Ichikura T, Mochizuki H, Shinomiya N (1998) Expression of cyclooxygenase-2 protein in gastric adenocarcinoma. J Surg Oncol 69:168–172CrossRefPubMed

38.

Uefuji K, Ichikura T, Mochizuki H (2000) Cyclooxygenase-2 expression is related to prostaglandin biosynthesis and angiogenesis in human gastric cancer. Clin Cancer Res 6:135–138PubMed

39.

Watanabe K, Kurihara K, Suzuki T (1999) Purification and characterization of membrane-bound prostaglandin E synthase from bovine heart. Biochim Biophys Acta 1439:406–414CrossRefPubMed

40.

Watanabe K, Kawamori T, Nakatsugi S, Ohta T, Ohuchida S, Yamamoto H, Maruyama T, Kondo K, Ushikubi F, Narumiya S, Sugimura T, Wakabayashi K (1999) Role of the prostaglandin E receptor subtype EP₁ in colon carcinogenesis. Cancer Res 59:5093–5096PubMed

41.

Yamagata K, Matsumura K, Inoue W, Shiraki T, Suzuki K, Yasuda S, Sugiura H, Cao C, Watanabe Y, Kobayashi S (2001) Coexpression of microsomal-type prostaglandin E synthase with cyclooxygenase-2 in brain endothelial cells of rats during endotoxin-induced fever. J Neurosci 21:2669–2677PubMed

42.

Yoshimatsu K, Altorki NK, Golijanin D (2001) Inducible prostaglandin E synthase is overexpressed in non-small cell lung cancer. Clin Cancer Res 7:2669–2674PubMed

43.

Yoshimatsu K, Golijanin D, Paty PB, Soslow RA, Jakobsson PJ, DeLellis RA, Subbaramaiah K, Dannenberg AJ (2001) Inducible microsomal prostaglandin E synthase is overexpressed in colorectal adenomas and cancer. Clin Cancer Res 7:3971–3976PubMed

Titel: Expression of proteins related to prostaglandin E2 biosynthesis is increased in human gastric cancer and during gastric carcinogenesis
verfasst von: Tae Jung Jang
Publikationsdatum: 01.12.2004
Verlag: Springer-Verlag
Erschienen in: Virchows Archiv / Ausgabe 6/2004
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-004-1104-3

Springer Medizin

Expression of proteins related to prostaglandin E₂ biosynthesis is increased in human gastric cancer and during gastric carcinogenesis

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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