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Virchows Archiv

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01.02.2010 | Review and Perspective

Soft tissue sarcomas with complex genomic profiles

verfasst von: Louis Guillou, Alain Aurias

Erschienen in: Virchows Archiv | Ausgabe 2/2010

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Abstract

Soft tissue sarcomas (STS) with complex genomic profiles (50% of all STS) are predominantly composed of spindle cell/pleomorphic sarcomas, including leiomyosarcoma, myxofibrosarcoma, pleomorphic liposarcoma, pleomorphic rhabdomyosarcoma, malignant peripheral nerve sheath tumor, angiosarcoma, extraskeletal osteosarcoma, and spindle cell/pleomorphic unclassified sarcoma (previously called spindle cell/pleomorphic malignant fibrous histiocytoma). These neoplasms show, characteristically, gains and losses of numerous chromosomes or chromosome regions, as well as amplifications. Many of them share recurrent aberrations (e.g., gain of 5p13-p15) that seem to play a significant role in tumor progression and/or metastatic dissemination. In this paper, we review the cytogenetic, molecular genetic, and clinicopathologic characteristics of the most common STS displaying complex genomic profiles. Features of diagnostic or prognostic relevance will be discussed when needed.

Fletcher CDM, Unni KK, Mertens F (eds) (2002) World Health Organization classification of tumours. Pathology and genetics of tumors of soft tissue and bone. IARC Press, Lyon

Weiss SW, Goldblum JR (2008) In: Weiss SW, Goldblum JR (eds) Enzinger and Weiss’s soft tissue tumors, 5th edn. Mosby-Elsevier, Philadelphia

Dei Tos AP (2006) Classification of pleomorphic sarcomas: where are we now? Histopathology 48:51–62PubMed

Sandberg AA (2005) Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: leiomyosarcoma. Cancer Genet Cytogenet 161:1–19PubMed

Mandahl N, Fletcher CDM, Dal Cin P et al (2000) Comparative cytogenetic study of spindle cell and pleomorphic leiomyosarcomas of soft tissues: a report from the CHAMP Study Group. Cancer Genet Cytogenet 116:66–73PubMed

Yang J, Du X, Chen K et al (2009) Genetic aberrations in soft tissue leiomyosarcoma. Cancer Lett 275:1–8PubMed

Fletcher CDM, Dal Cin P, De Wever I et al (1999) Correlation between clinicopathologic features and karyotype in spindle cell sarcomas. A report of 130 cases from the CHAMP Study Group. Am J Pathol 154:1841–1847PubMed

Wang R, Titley JC, Lu YJ et al (2003) Loss of 13q14–q21 and gain of 5p14-pter in the progression of leiomyosarcoma. Mod Pathol 16:778–785PubMed

Hu J, Rao UNM, Jasani S et al (2005) Loss of DNA copy number of 10q is associated with aggressive behavior of leiomyosarcomas: a comparative genomic hybridization study. Cancer Genet Cytogenet 161:20–27PubMed

10.

Adamowicz M, Radlwimmer B, Rieker RJ et al (2006) Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas. Genes Chromosomes Cancer 45:829–838PubMed

11.

Hernando E, Charytonowicz E, Dudas ME et al (2007) The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas. Nat Med 13:748–753PubMed

12.

Bjornsti MA, Houghton PJ (2004) The TOR pathway: a target for cancer therapy. Nat Med 10:594–601

13.

Mita MM, Tolcher AW (2007) The role of mTOR inhibitors for treatment of sarcomas. Current Oncology Reports 9:316–322PubMed

14.

Lee YF, John M, Falconer A et al (2004) A gene expression signature associated with metastatic outcome in human leiomyosarcomas. Cancer Res 64:7201–7204PubMed

15.

Ren B, Yu YP, Jing L et al (2003) Gene expression analysis of human soft tissue leiomyosarcomas. Hum Pathol 34:549–558PubMed

16.

Suehara Y, Kondo T, Fujii K et al (2006) Proteomic signatures corresponding to histological classification and grading of soft-tissue sarcomas. Proteomics 6:4402–4409PubMed

17.

Kawaguchi K, Oda Y, Saito T et al (2003) Mechanisms of inactivation of the p16INK4a gene in leiomyosarcoma of soft tissue: decrease. J Pathol 201:487–495PubMed

18.

Dei Tos AP, Maestro R, Doglioni C et al (1996) Tumor suppressor genes and related molecules in leiomyosarcoma. Am J Pathol 148:1037–1045PubMed

19.

Seidel C, Bartel F, Rastetter M et al (2005) Alterations of cancer-related genes in soft tissue sarcomas: hypermethylation of RASSF1A is frequently detected in leiomyosarcoma and associated with poor prognosis in sarcoma. Int J Cancer 114:442–447PubMed

20.

Kawaguchi K, Oda Y, Saito T et al (2006) DNA hypermethylation status of multiple genes in soft tissue sarcomas. Mod Pathol 19:106–114PubMed

21.

Francis P, Namlos HM, Müller C et al (2007) Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas: hypoxia-induced transcription profile signifies metastatic potential. BMC Genomics 8:73PubMed

22.

Pérot G, Derré J, Coindre JM et al (2009) Strong smooth muscle differentiation is dependent on myocardin gene amplification in most human retroperitoneal leiomyosarcomas. Cancer Res 69:2269–2278PubMed

23.

Deyrup AT, Lee VK, Hill CE et al (2006) Epstein–Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients. Am J Surg Pathol 30:75–82PubMed

24.

Kubben FJGM, Kroon FP, Hogendoorn PCW et al (1997) Absence of Epstein–Barr virus in a gastrointestinal stromal cell tumour (GIST) in an adult human immunodeficiency virus-seropositive patient with past Epstein–Barr virus (EBV) infection. Eur J Gastroent Hepatol 9:721–724

25.

Moinfar F, Azodi M, Tavassoli FA (2007) Uterine sarcomas. Pathology 39:55–71PubMed

26.

Quade BJ, Wang TY, Sornberger K et al (2004) Molecular pathogenesis of uterine smooth muscle tumors from transcriptional profiling. Genes Chromosomes Cancer 40:97–108PubMed

27.

Miettinen M, Fetsch JF (2006) Evaluation of biological potential of smooth muscle tumours. Histopathology 48:97–105PubMed

28.

Fletcher CD (1992) Pleomorphic malignant fibrous histiocytoma: fact or fiction? A critical reappraisal based on 159 tumors diagnosed as pleomorphic sarcoma. Am J Surg Pathol 16:213–228PubMedCrossRef

29.

Fletcher CDM (2006) The evolving classification of soft tissue tumours: an update based on the new WHO classification. Histopathology 48:3–12PubMed

30.

Mertens F, Fletcher CDM, Dal Cin P et al (1998) Cytogenetic analysis of 46 pleomorphic soft tissue sarcomas and correlation with morphologic and clinical features: a report of the CHAMP Study Group. Genes Chromosomes Cancer 22:16–25PubMed

31.

Derré J, Lagacé R, Nicolas A et al (2001) Leiomyosarcomas and most malignant fibrous histiocytomas share very similar comparative genomic hybridization imbalances: an analysis of a series of 27 leiomyosarcomas. Lab Invest 81:211–215PubMed

32.

Carneiro A, Francis P, Bendahl PO et al (2009) Indistinguishable genomic profiles and shared prognostic markers in undifferentiated pleomorphic sarcoma and leiomyosarcoma: different sides of a single coin? Lab Invest 89:668–675PubMed

33.

Larramendy ML, Gentile M, Soloneski S et al (2008) Does comparative genomic hybridization reveal differences in DNA copy number sequence patterns between leiomyosarcoma and malignant fibrous histiocytoma? Cancer Genet Cytogenet 187:1–11PubMed

34.

Kawai A, Kondo T, Suehara Y et al (2008) Global protein-expression analysis of bone and soft tissue sarcomas. Clin Orthop Relat Res 466:2099–2106PubMed

35.

Mairal A, Terrier P, Chibon F et al (1999) Loss of chromosome 13 is the most frequent genomic imbalance in malignant fibrous histiocytomas: a comparative genomic hybridization analysis of a series of 30 cases. Cancer Genet Cytogenet 111:134–138PubMed

36.

Chibon F, Mairal A, Fréneaux P et al (2000) The RB1 gene is the target of chromosome 13 deletions in malignant fibrous histiocytoma. Cancer Res 60:6339–6345PubMed

37.

Nakayama R, Nemoto T, Takahashi H et al (2007) Gene expression analysis of soft tissue sarcomas: characterization and reclassification of malignant fibrous histiocytoma. Mod Pathol 20:749–759PubMed

38.

Shintani K, Matsumine A, Kusuzaki K et al (2006) Expression of hypoxia-inducible factor (HIF)-I alpha as a biomarker of outcome in soft tissue sarcomas. Virchows Arch 449:673–681PubMed

39.

Hunter KW (2004) Ezrin, a key component in tumor metastasis. Trends Mol Med 10:201–204PubMed

40.

Kim MS, Cho WH, Song WS et al (2007) Prognostic significance of ezrin expression in pleomorphic malignant fibrous histiocytoma. Anticancer Res 27:1171–1178PubMed

41.

Weng WH, Ahlén J, Aström K et al (2005) Prognostic impact of immunohistochemical expression of ezrin in highly malignant soft tissue sarcomas. Clinical Cancer Res 11:6198–6204

42.

Riggi N, Cironi L, Provero P et al (2005) Development of Ewing’s sarcoma from bone-marrow-derived mesenchymal progenitor cells. Cancer Res 65:11459–11468PubMed

43.

Riggi N, Cironi L, Provero P et al (2006) Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma. Cancer Res 66:7016–7023PubMed

44.

Matuschansky I, Hernando E, Socci ND et al (2007) Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway. J Clin Invest 117:3248–3257

45.

Fletcher CD, Gustafson P, Rydholm A et al (2001) Clinicopathologic re-evaluation of 100 malignant fibrous histiocytomas: prognostic relevance of subclassification. J Clin Oncol 19:3045–3050PubMed

46.

Deyrup AT, Haydon RC, Huo D et al (2003) Myoid differentiation and prognosis in adult pleomorphic sarcomas of the extremity: an analysis of 92 cases. Cancer 98:805–813PubMed

47.

Bui Nguyen Binh M, Guillou L, Hostein I et al (2007) Dedifferentiated liposarcomas with divergent myosarcomatous differentiation developed in the internal trunk. A study of 27 cases and comparison to conventional dedifferentiated liposarcomas and leiomyosarcomas. Am J Surg Pathol 31:1557–1566PubMed

48.

Montgomery E, Fisher C (2001) Myofibroblastic differentiation in malignant fibrous histiocytoma (pleomorphic myofibrosarcoma): a clinicopathological study. Histopathology 38:499–509PubMed

49.

Fisher C (2004) Myofibrosarcoma. Virchows Arch 445:215–223PubMed

50.

Merck C, Angervall L, Kindblom LG et al (1983) Myxofibrosarcoma. A malignant soft tissue tumor of fibroblastic–histiocytic origin. A clinicopathologic and prognostic study of 110 cases using multivariate analysis. Acta Pathol Microbiol Immunol Scand Suppl 282:1–40PubMed

51.

Mentzel T, Calonje E, Wadden C et al (1996) Myxofibrosarcoma: clinicopathologic analysis of 75 cases with emphasis on the low grade variant. Am J Surg Pathol 20:391–405PubMed

52.

Huang HY, Lal P, Qin J et al (2004) Low-grade myxofibrosarcoma: a clinicopathologic analysis of 49 cases treated at a single institution with simultaneous assessment of the efficacy of 3-tier and 4-tier grading systems. Hum Pathol 35:612–621PubMed

53.

Lin CN, Chou SC, Li CF et al (2006) Prognostic factors of myxofibrosarcomas: implications of margin status, tumor necrosis, and mitotic rate on survival. J Surg Oncol 93:294–3043PubMed

54.

Idbaih A, Coindre JM, Derré J et al (2005) Myxoid malignant fibrous histiocytoma and pleomorphic liposarcoma share very similar genomic imbalances. Lab Invest 85:176–181PubMed

55.

Willems SM, Debiec-Rychter M, Szuhai K et al (2006) Local recurrence of myxofibrosarcoma is associated with increased in tumour grade and cytogenetic aberrations, suggesting a multistep tumour progression model. Mod Pathol 19:407–416PubMed

56.

Willems SM, Mohseny AB, Balog C et al (2009) Cellular/intramuscular myxoma and grade I myxofibrosarcoma are characterized by distinct genetic alterations and specific composition of their extracellular matrix. J Cell Mol Med 13:1291–1301PubMed

57.

Nascimento AF, Bertoni F, Fletcher CDM (2007) Epithelioid variant of myxofibrosarcoma: expanding the clinicomorphologic spectrum of myxofibrosarcoma in a series of 17 cases. Am J Surg Pathol 31:99–105PubMed

58.

Gebhard S, Coindre JM, Michels JJ et al (2002) Pleomorphic liposarcoma: clinicopathologic, immunohistochemical, and follow-up analysis of 63 cases. A study from the French Federation of Cancer Centers Sarcoma Group. Am J Surg Pathol 26:601–616PubMed

59.

Hornick JL, Bosenberg MW, Mentzel T et al (2004) Pleomorphic liposarcoma. Clinicopathologic analysis of 57 cases. Am J Surg Pathol 28:1257–1267PubMed

60.

Miettinen M, Enzinger FM (1999) Epithelioid variant of pleomorphic liposarcoma: a study of 12 cases of a distinctive variant of high-grade liposarcoma. Mod Pathol 12:722–728PubMed

61.

Sandberg AA (2004) Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. Liposarcoma. Cancer Genet Cytogenet 155:1–24PubMed

62.

Schmidt H, Bartel F, Kappler M et al (2005) Gains of 13q are correlated with a poor prognosis in liposarcoma. Mod Pathol 18:638–644PubMed

63.

Taylor BS, Barretina J, Socci ND et al (2008) Functional copy-number alterations in cancer. PLoS ONE 3:e3179PubMed

64.

Rieker RJ, Joos S, Bartsch C et al (2002) Distinct chromosomal imbalances in pleomorphic and in high-grade dedifferentiated liposarcomas. Int J Cancer 99:68–73PubMed

65.

Fritz B, Schubert F, Wrobel G et al (2002) Microarray-based copy number and expression profiling in dedifferentiated and pleomorphic liposarcoma. Cancer Res 62:2993–2998PubMed

66.

Singer S, Socci ND, Ambrosini G et al (2007) Gene expression profiling of liposarcoma identifies distinct biological types/subtypes and potential therapeutic targets in well-differentiated and dedifferentiated liposarcoma. Cancer Res 67:6626–6636PubMed

67.

Matuschansky I, Hernando E, Socci ND et al (2008) A development model of sarcomagenesis defines a differentiation-based classification for liposarcomas. Am J Pathol 172:1069–1080

68.

Dei Tos AP, Mentzel T, Fletcher CDM (1998) Primary liposarcoma of the skin: a rare neoplasm with unusual high grade features. Am J Dermatopathol 20:332–338PubMed

69.

Furlong MA, Mentzel T, Fanburg-Smith JC (2001) Pleomorphic rhabdomyosarcoma in adults: a clinicopathologic study of 38 cases with emphasis on morphologic variants and recent skeletal muscle-specific markers. Mod Pathol 14:595–603PubMed

70.

Furlong MA, Fanburg-Smith JC (2001) Pleomorphic rhabdomyosarcoma in children: four cases in the pediatric age group. Ann Diagn Pathol 5:199–206PubMed

71.

Little DJ, Ballo MT, Zagars GK et al (2002) Adult rhabdomyosarcoma. Outcome following multimodality treatment. Cancer 95:377–388PubMed

72.

Parham DM, Ellison DA (2006) Rhabdomyosarcomas in adults and children. An update. Arch Pathol Lab Med 130:1454–1465PubMed

73.

Li G, Ogose A, Kawashima H et al (2009) Cytogenetic and real-time quantitative reverse-transcriptase polymerase chain reaction analyses in pleomorphic rhabdomyosarcoma. Cancer Genet Cytogenet 192:1–9PubMed

74.

Gordon A, McManus A, Anderson J et al (2003) Chromosomal imbalances in pleomorphic rhabdomyosarcomas and identification of the alveolar rhabdomyosarcoma-associated PAX3-FOXO1A fusion gene in one case. Cancer Genet Cytogenet 140:73–77PubMed

75.

Scheithauer BW, Louis DN, Hunter S et al (2007) Malignant peripheral nerve sheath tumour (MPNST). In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (eds) World Health Organization classification of tumours of the central nervous system. IARC, Lyon, pp 160–162

76.

Mertens F, Dal Cin P, De Wever I et al (2000) Cytogenetic characterization of peripheral nerve sheath tumours: a report of the CHAMP Study Group. J Pathol 190:31–38PubMed

77.

Bridge RS, Bridge JA, Neff JR et al (2004) Recurrent chromosomal imbalances and structurally abnormal breakpoints within complex karyotypes of malignant peripheral nerve sheath tumour and malignant Triton tumor: a cytogenetic and molecular cytogenetic study. J Clin Pathol 57:1172–1178PubMed

78.

Kresse SH, Skarn M, Ohnstad HO et al (2008) DNA copy number changes in high-grade malignant peripheral nerve sheath tumors by array CGH. Mol Cancer 7:48PubMed

79.

Storlazzi CT, Brekke HR, Mandahl N et al (2006) Identification of a novel amplicon at distal 17q containing the BIRC5/survivin gene in malignant peripheral nerve sheath tumours. J Pathol 209:492–500PubMed

80.

Schmidt H, Würl P, Taubert H et al (1999) Genomic imbalances in 7p and 17q in malignant peripheral nerve sheath tumors are clinically relevant. Genes Chromosomes Cancer 25:205–211PubMed

81.

Skotheim RI, Kallioniemi A, Bjerkhagen B et al (2003) Topoisomerase-II α is upregulated in malignant peripheral nerve sheath tumors and associated with clinical outcome. J Clin Oncol 21:4586–4591PubMed

82.

Schmidt H, Taubert H, Würl P et al (2001) Cytogenetic characterization of six malignant peripheral nerve sheath tumors: comparison of karyotyping and comparative genomic hybridization. Cancer Genet Cytogenet 128:14–23PubMed

83.

Mantripragada KK, Spurlock G, Kluwe L et al (2008) High-resolution DNA copy number profiling of malignant peripheral nerve sheath tumors using targeted microarray-based comparative genomic hybridization. Clinical Cancer Res 14:1015–1024

84.

Carroll SL, Stonecypher MS (2004) Tumor suppressor mutations and growth factor signalling in the pathogenesis of NF1-associated peripheral nerve sheath tumors. I. The role of tumor suppressor mutations. J Neuropathol Exp Neurol 63:1115–1123PubMed

85.

Przygodzki RM, Finkelstein SD, Keohavong P et al (1997) Sporadic and thorotrast-induced angiosarcomas of the liver manifest frequent and multiple point mutations in KRAS-2. Lab Invest 76:153–159PubMed

86.

Naka N, Tomita Y, Nakanishi H et al (1997) Mutations of p53 tumor suppressor gene in angiosarcoma. Int J Cancer 71:952–955PubMed

87.

Zietz C, Rossle M, Haas C et al (1998) MDM2 oncoprotein overexpression, p53 gene mutation, and VEGF upregulation in angiosarcomas. Am J Pathol 153:1425–1433PubMed

88.

Domfeh AB, Fichera M, Hunt JL (2006) Allelic loss of 3 different tumor suppressor gene loci in benign and malignant endothelial tumors of the head and neck. Arch Pathol Lab Med 130:1184–1187PubMed

89.

Ahmad SA, Patel SR, Ballo MT et al (2002) Extraosseous osteosarcoma: response to treatment and long-term outcome. J Clin Oncol 20:521–527PubMed

90.

Jensen ML, Schumacher B, Jensen OM et al (1998) Extraskeletal osteosarcomas. A clinicopathologic study of 25 cases. Am J Surg Pathol 22:588–594

91.

Mertens F, Larramendy M, Gustavsson A et al (2000) Radiation-associated sarcomas are characterized by complex karyotypes with frequent rearrangements of chromosome arm 3p. Cancer Genet Cytogenet 116:89–96PubMed

92.

Mohamed AN, Zalupski MM, Ryan JR et al (1997) Cytogenetic aberrations and DNA ploidy in soft tissue sarcoma. A southwest oncology group study. Cancer Genet Cytogenet 99:45–53PubMed

93.

Lau CC, Harris CP, Lu XY et al (2004) Frequent amplification and rearrangement of chromosomal bands 6p12–p21 and 17p11.2 in osteosarcoma. Genes Chromosomes Cancer 39:11–21PubMed

94.

Selvarajah S, Yoshimoto M, Ludkovski O et al (2008) Genomic signatures of chromosomal instability and osteosarcoma progression detected by high resolution array CGH and interphase FISH. Cytogenet Genome Res 122:5–15PubMed

95.

Bayani J, Zielenska M, Pandita A et al (2003) Spectral karyotyping identifies recurrent complex rearrangements of chromosomes 8, 17, and 20 in osteosarcomas. Genes Chromosomes Cancer 36:7–16PubMed

96.

Bridge JA, Nelson M, McComb E et al (1997) Cytogenetic findings in 73 osteosarcoma specimens and a review of the literature. Cancer Genet Cytogenet 95:74–87PubMed

97.

Sandberg AA, Bridge JA (2003) Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. Osteosarcoma and related tumors. Cancer Genet Cytogenet 145:1–30PubMed

98.

Montgomery EA, Devaney KO, Giordano TJ et al (1998) Inflammatory myxohyaline tumor of distal extremities with virocyte or Reed-Sternberg-like cells: a distinctive lesion with features simulating inflammatory conditions, Hodgkin's disease, and various sarcomas. Mod Pathol 11:384–391PubMed

99.

Meis-Kindblom JM, Kindblom LG (1998) Acral myxoinflammatory fibroblastic sarcoma: a low-grade tumor of the hands and feet. Am J Surg Pathol 22:911–924PubMed

100.

Lambert I, Debiec-Rychter M, Guelinckx P et al (2001) Acral myxoinflammatory fibroblastic sarcoma with unique clonal chromosomal changes. Virchows Arch 438:509–512PubMed

101.

Baumhoer D, Glatz K, Schulten H-J et al (2007) Myxoinflammatory fibroblastic sarcoma: investigations by comparative genomic hybridization of two cases and review of the literature. Virchows Arch 451:923–928PubMed

102.

Mansoor A, Fidda N, Himoe E et al (2004) Myxoinflammatory fibroblastic sarcoma with complex supernumerary ring chromosomes composed of chromosome 3 segments. Cancer Genet Cytogenet 152:61–65PubMed

103.

Hallor KH, Sciot R, Staaf J et al (2009) Two genetic pathways, t(1;10) and amplification of 3p11–12, in myxoinflammatory fibroblastic sarcoma, haemosiderotic fibrolipomatous tumour, and morphologically similar lesions. J Pathol 217:716–727PubMed

104.

Ida CM, Rolig KA, Hulshizer RL et al (2007) Myxoinflammatory fibroblastic sarcoma showing t(2;6)(q31;p21.3) as a sole cytogenetic abnormality. Cancer Genet Cytogenet 177:139–142PubMed

105.

Laskin WB, Silverman TA, Enzinger FM (1998) Postradiation soft tissue sarcomas. An analysis of 53 cases. Cancer 62:2330–2340

106.

Wiklund TA, Blomqvist CP, Raty J et al (1991) Postirradiation sarcoma. Analysis of a nationwide cancer registry material. Cancer 68:524–531PubMed

107.

Lagrange JL, Ramaioli A, Chateau MC et al (2000) Sarcoma after radiation therapy: retrospective multi institutional study of 80 histologically confirmed cases. Radiation therapist and pathologist groups of the Federation Nationale des Centres de Lutte Contre le Cancer. Radiology 216:197–205PubMed

108.

Inoue YZ, Frassica FJ, Sim FH et al (2000) Clinicopathologic features and treatment of postirradiation sarcoma of bone and soft tissue. J Surg Oncol 75:42–50PubMed

109.

Nakanishi H, Tomita Y, Myoui A et al (1998) Mutation of the p53 gene in postradiation sarcoma. Lab Invest 78:727–733PubMed

Titel: Soft tissue sarcomas with complex genomic profiles
verfasst von: Louis Guillou
Alain Aurias
Publikationsdatum: 01.02.2010
Verlag: Springer-Verlag
Erschienen in: Virchows Archiv / Ausgabe 2/2010
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-009-0853-4

Springer Medizin

Soft tissue sarcomas with complex genomic profiles

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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