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Journal of Cancer Research and Clinical Oncology
Erschienen in: Journal of Cancer Research and Clinical Oncology 10/2010

01.10.2010 | Original Paper

Perineural invasion in carcinoma of the cervix uteri—prognostic impact

verfasst von: Lars-Christian Horn, Alexandra Meinel, Uta Fischer, Karl Bilek, Bettina Hentschel

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 10/2010

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Abstract

Purpose

Limited information exists about the occurrence and the impact of perineural invasion (PNI) in patients with cervical carcinoma (CX).

Methods

The original histologic slides from patients primarily treated by radical hysterectomy and systematic pelvic lymphadenectomy were re-examined regarding the occurrence of PNI. PNI was correlated to recurrence free (RFS) and overall survival (OS).

Results

35.1% of all patients (68/194) represented perineural invasion (=PNI). The 5-year-overall-survival-rate was significantly decreased in patients representing PNI, when they were compared with those without PNI (51.1% [95% CI 38.0–64.2] vs. 75.6% [95% CI 67.8–83.4]; p = 0.001). In a separate analysis the prognostic impact persisted in the node negative, but disappeared in the node-positive cases. In multivariate analysis, pelvic lymph node involvement and PNI were independent prognostic factors for overall survival.

Conclusions

Perineural invasion is seen in about one-third of patients with cervical carcinoma. Patients affected by PNI represented a decreased overall survival. Further studies are required to get a deeper insight into the clinical impact and the pathogenetic mechanisms of PNI in CX.
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Metadaten
Titel
Perineural invasion in carcinoma of the cervix uteri—prognostic impact
verfasst von
Lars-Christian Horn
Alexandra Meinel
Uta Fischer
Karl Bilek
Bettina Hentschel
Publikationsdatum
01.10.2010
Verlag
Springer-Verlag
Erschienen in
Journal of Cancer Research and Clinical Oncology / Ausgabe 10/2010
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI
https://doi.org/10.1007/s00432-010-0813-z

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