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Current Neurology and Neuroscience Reports

Erschienen in:

01.04.2011

Asymptomatic Sleep Abnormalities Are a Common Early Feature in Patients with Huntington’s Disease

verfasst von: Anna O. G. Goodman, Lorraine Rogers, Samantha Pilsworth, Catherine J. McAllister, John M. Shneerson, A. Jennifer Morton, Roger A. Barker

Erschienen in: Current Neurology and Neuroscience Reports | Ausgabe 2/2011

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Abstract

Huntington’s disease (HD) is a fatal neurodegenerative disease characterized by motor, cognitive, and psychiatric disturbance. In this article, we used polysomnography, actigraphy and a variety of validated questionnaires to ascertain the extent to which sleep changes are identifiable and measurable in mild stage HD, and importantly, to see whether patients are negatively impacted by the changes in their sleep. We found significant differences in sleep architecture and sleep efficiency in patients compared with controls using polysomnography. However, patient scores on the Functional Outcomes of Sleep Questionnaire, Medical Outcomes of Sleep Scale, and Epworth Sleepiness Scale were not significantly different to controls. These results suggest that although marked changes in sleep architecture are present in early HD and can be detected using polysomnography, patients do not necessarily recognize or report these abnormalities.

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Titel: Asymptomatic Sleep Abnormalities Are a Common Early Feature in Patients with Huntington’s Disease
verfasst von: Anna O. G. Goodman
Lorraine Rogers
Samantha Pilsworth
Catherine J. McAllister
John M. Shneerson
A. Jennifer Morton
Roger A. Barker
Publikationsdatum: 01.04.2011
Verlag: Current Science Inc.
Erschienen in: Current Neurology and Neuroscience Reports / Ausgabe 2/2011
Print ISSN: 1528-4042
Elektronische ISSN: 1534-6293
DOI: https://doi.org/10.1007/s11910-010-0163-x

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