Background
Methods
Predictor variable
Outcome variable
Individual-level variables adjusted for in the model
Statistical analysis
Results
Men | Women | All | ||||
---|---|---|---|---|---|---|
Immune-mediated disease
| No | % | No | % | No | % |
Addison disease | 862 | 1.05 | 1190 | 0.89 | 2052 | 0.95 |
Amyotrophic lateral sclerosis | 2376 | 2.89 | 2055 | 1.53 | 4431 | 2.05 |
Ankylosing spondylitis | 2416 | 2.94 | 1061 | 0.79 | 3477 | 1.61 |
Autoimmune hemolytic anemia | 312 | 0.38 | 391 | 0.29 | 703 | 0.33 |
Behcet disease | 146 | 0.18 | 138 | 0.10 | 284 | 0.13 |
Celiac disease | 2639 | 3.21 | 4249 | 3.17 | 6888 | 3.18 |
Chorea minor | 10 | 0.01 | 25 | 0.02 | 35 | 0.02 |
Crohn disease | 9522 | 11.58 | 10700 | 7.98 | 20222 | 9.35 |
Diabetes mellitus type I | 9068 | 11.02 | 7664 | 5.72 | 16732 | 7.74 |
Discoid lupus erythematosus | 54 | 0.07 | 200 | 0.15 | 254 | 0.12 |
Grave disease | 3764 | 4.58 | 18298 | 13.65 | 22062 | 10.20 |
Hashimoto thyroiditis | 1440 | 1.75 | 5115 | 3.82 | 6555 | 3.03 |
Immune thrombocytopenic purpura | 1905 | 2.32 | 2039 | 1.52 | 3944 | 1.82 |
Localized scleroderma | 90 | 0.11 | 422 | 0.31 | 512 | 0.24 |
Lupoid hepatitis | 115 | 0.14 | 274 | 0.20 | 389 | 0.18 |
Multiple sclerosis | 3492 | 4.25 | 6892 | 5.14 | 10384 | 4.80 |
Myasthenia gravis | 935 | 1.14 | 1149 | 0.86 | 2084 | 0.96 |
Pernicious anemia | 1663 | 2.02 | 1868 | 1.39 | 3531 | 1.63 |
Polyarteritis nodosa | 437 | 0.53 | 386 | 0.29 | 823 | 0.38 |
Polymyalgia rheumatica | 5313 | 6.46 | 11183 | 8.34 | 16496 | 7.63 |
Polymyositis/dermatomyositis | 404 | 0.49 | 667 | 0.50 | 1071 | 0.50 |
Primary biliary cirrhosis | 124 | 0.15 | 675 | 0.50 | 799 | 0.37 |
Psoriasis | 4471 | 5.44 | 4558 | 3.40 | 9029 | 4.17 |
Reiter disease | 280 | 0.34 | 58 | 0.04 | 338 | 0.16 |
Rheumatic fever | 236 | 0.29 | 228 | 0.17 | 464 | 0.21 |
Rheumatoid arthritis | 12080 | 14.69 | 32531 | 24.27 | 44611 | 20.63 |
Sarcoidosis | 2847 | 3.46 | 2518 | 1.88 | 5365 | 2.48 |
Sjören syndrome | 125 | 0.15 | 1175 | 0.88 | 1300 | 0.60 |
Systemic lupus erythematosus | 742 | 0.90 | 3437 | 2.56 | 4179 | 1.93 |
Systemic sclerosis | 402 | 0.49 | 1356 | 1.01 | 1758 | 0.81 |
Ulcerative colitis | 12963 | 15.76 | 10647 | 7.94 | 23610 | 10.92 |
Wegener granulomatosis | 1025 | 1.25 | 884 | 0.66 | 1909 | 0.88 |
All | 82258 | 100.00 | 134033 | 100.00 | 216291 | 100.00 |
All stroke events | Subsequent stroke events of auto immune disorders patients | |||||||
---|---|---|---|---|---|---|---|---|
Hemorrhagic stroke | Ischeamic stroke | Hemorrhagic stroke | Ischeamic stroke | |||||
Characteristics | No. | % | No. | % | No. | % | No. | % |
Gender | ||||||||
Men | 36639 | 55.1 | 216802 | 50.7 | 566 | 38.6 | 3216 | 34.1 |
Women | 29870 | 44.9 | 211229 | 49.3 | 902 | 61.4 | 6221 | 65.9 |
Age at diagnosis (yrs) | ||||||||
<50 | 5070 | 7.6 | 13632 | 3.2 | 73 | 5.0 | 221 | 2.3 |
50-59 | 6857 | 10.3 | 29285 | 6.8 | 120 | 8.2 | 439 | 4.7 |
60-69 | 12399 | 18.6 | 71089 | 16.6 | 249 | 17.0 | 1263 | 13.4 |
70-79 | 21079 | 31.7 | 145288 | 33.9 | 476 | 32.4 | 3208 | 34.0 |
> = 80 | 21104 | 31.7 | 168737 | 39.4 | 550 | 37.5 | 4306 | 45.6 |
Period of diagnosis (yrs) | ||||||||
1987-91 | 13074 | 19.7 | 90088 | 21.0 | 134 | 9.1 | 832 | 8.8 |
1992-96 | 15114 | 22.7 | 110525 | 25.8 | 299 | 20.4 | 2183 | 23.1 |
1997-01 | 15773 | 23.7 | 97993 | 22.9 | 389 | 26.5 | 2626 | 27.8 |
2002-08 | 22548 | 33.9 | 129425 | 30.2 | 646 | 44.0 | 3796 | 40.2 |
Socioeconomic status | ||||||||
Farmers | 4797 | 7.2 | 34375 | 8.0 | 109 | 7.4 | 773 | 8.2 |
Self-employed | 4911 | 7.4 | 31497 | 7.4 | 95 | 6.5 | 654 | 6.9 |
Professionals | 4726 | 7.1 | 25561 | 6.0 | 70 | 4.8 | 438 | 4.6 |
White collar workers | 18912 | 28.4 | 119320 | 27.9 | 476 | 32.4 | 2773 | 29.4 |
Workers | 29487 | 44.3 | 197833 | 46.2 | 653 | 44.5 | 4406 | 46.7 |
Others | 3676 | 5.5 | 19445 | 4.5 | 65 | 4.4 | 393 | 4.2 |
Region of residence | ||||||||
Big cities | 22409 | 33.7 | 145119 | 33.9 | 429 | 29.2 | 2915 | 30.9 |
Northern Sweden | 12936 | 19.4 | 80680 | 18.8 | 310 | 21.1 | 1972 | 20.9 |
Southern Sweden | 31164 | 46.9 | 202232 | 47.2 | 729 | 49.7 | 4550 | 48.2 |
Hospitalization for obesity | ||||||||
Yes | 114 | 0.2 | 703 | 0.2 | 2 | 0.1 | 30 | 0.3 |
No | 66395 | 99.8 | 427328 | 99.8 | 1466 | 99.9 | 9407 | 99.7 |
Hospitalization for alcoholism | ||||||||
Yes | 2265 | 3.4 | 7448 | 1.7 | 45 | 3.1 | 143 | 1.5 |
No | 64244 | 96.6 | 420583 | 98.3 | 1423 | 96.9 | 9294 | 98.5 |
Hospitalization for chronic lower respiratory diseases | ||||||||
Yes | 2067 | 3.1 | 18287 | 4.3 | 63 | 4.3 | 613 | 6.5 |
No | 64442 | 96.9 | 409744 | 95.7 | 1405 | 95.7 | 8824 | 93.5 |
Hospitalization for hypertension | ||||||||
Yes | 2254 | 3.4 | 16998 | 4.0 | 48 | 3.3 | 434 | 4.6 |
No | 64255 | 96.6 | 411033 | 96.0 | 1420 | 96.7 | 9003 | 95.4 |
Hospitalization for diabetes type II | ||||||||
Yes | 2425 | 3.6 | 28091 | 6.6 | 77 | 5.2 | 726 | 7.7 |
No | 64084 | 96.4 | 399940 | 93.4 | 1391 | 94.8 | 8711 | 92.3 |
Hospitalization for artrial fibrillation | ||||||||
Yes | 4174 | 6.3 | 47257 | 11.0 | 134 | 9.1 | 1351 | 14.3 |
No | 62335 | 93.7 | 380774 | 89.0 | 1334 | 90.9 | 8086 | 85.7 |
Hospitalization for heart failure | ||||||||
Yes | 4619 | 6.9 | 63904 | 14.9 | 129 | 8.8 | 1749 | 18.5 |
No | 61890 | 93.1 | 364127 | 85.1 | 1339 | 91.2 | 7688 | 81.5 |
Hospitalization for renal disease | ||||||||
Yes | 2656 | 4.0 | 19793 | 4.6 | 105 | 7.2 | 718 | 7.6 |
No | 63853 | 96.0 | 408238 | 95.4 | 1363 | 92.8 | 8719 | 92.4 |
Hospitalization for sepsis | ||||||||
Yes | 2167 | 3.3 | 15738 | 3.7 | 77 | 5.2 | 615 | 6.5 |
No | 64342 | 96.7 | 412293 | 96.3 | 1391 | 94.8 | 8822 | 93.5 |
Hospitalization for coronary heart disease | ||||||||
Yes | 9323 | 14.0 | 108895 | 25.4 | 234 | 15.9 | 2589 | 27.4 |
No | 57186 | 86.0 | 319136 | 74.6 | 1234 | 84.1 | 6848 | 72.6 |
All | 66509 | 100.0 | 428031 | 100.0 | 1468 | 100.0 | 9437 | 100.0 |
Hemorrhagic stroke
Follow-up interval (years) | ||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
<1 | 1-5 | 5-10 | > = 10 | All | ||||||||||||||||
Immune-mediated diseases | O | SIR | 95% CI | O | SIR | 95% CI | O | SIR | 95% CI | O | SIR | 95% CI | O | SIR | 95% CI | |||||
Addison´s disease | 2 | 2.70 | 0.25 | 9.94 | 2 | 0.64 | 0.06 | 2.34 | 1 | 0.42 | 0.00 | 2.41 | 1 | 0.55 | 0.00 | 3.17 | 6 | 0.74 | 0.27 | 1.63 |
Amyotrophic lateral sclerosis | 1 | 0.47 | 0.00 | 2.68 | 2 | 1.30 | 0.12 | 4.78 | 1 | 1.82 | 0.00 | 10.42 | 0 | 4 | 0.89 | 0.23 | 2.30 | |||
Ankylosing spondylitis | 6 |
8.11
|
2.92
|
17.76
| 15 |
3.43
|
1.92
|
5.68
| 7 | 1.66 | 0.66 | 3.44 | 14 |
2.28
|
1.24
|
3.84
| 42 |
2.72
|
1.96
|
3.67
|
Autoimmune hemolytic anemia | 1 | 3.13 | 0.00 | 17.91 | 4 | 2.96 | 0.77 | 7.66 | 1 | 1.15 | 0.00 | 6.59 | 2 | 2.99 | 0.28 | 10.98 | 8 |
2.49
|
1.06
|
4.93
|
Behcet´s disease | 1 | 33.33 | 0.01 | 191.08 | 0 | 0 | 0 | 1 | 1.67 | 0.00 | 9.55 | |||||||||
Celiac disease | 2 | 3.57 | 0.34 | 13.13 | 6 | 2.08 | 0.75 | 4.56 | 7 |
2.69
|
1.07
|
5.58
| 8 |
2.65
|
1.13
|
5.25
| 23 |
2.54
|
1.61
|
3.81
|
Chorea minor | 0 | 0 | 0 | 0 | 0 | |||||||||||||||
Crohn disease | 5 | 1.47 | 0.46 | 3.46 | 47 |
2.60
|
1.91
|
3.46
| 19 | 1.19 | 0.72 | 1.87 | 24 |
1.57
|
1.00
|
2.34
| 95 |
1.80
|
1.46
|
2.21
|
Diabetes mellitus type I | 0 | 2 | 2.50 | 0.24 | 9.19 | 1 | 1.11 | 0.00 | 6.37 | 2 | 1.01 | 0.09 | 3.70 | 5 | 1.32 | 0.42 | 3.10 | |||
Discoid lupus erythematosus | 1 | 11.11 | 0.00 | 63.69 | 1 | 2.33 | 0.00 | 13.33 | 0 | 0 | 2 | 1.87 | 0.18 | 6.87 | ||||||
Grave´s disease | 8 | 1.53 | 0.65 | 3.02 | 58 |
1.77
|
1.35
|
2.29
| 48 |
1.61
|
1.18
|
2.13
| 41 |
1.48
|
1.06
|
2.02
| 155 |
1.62
|
1.38
|
1.90
|
Hashimoto´s thyroiditis | 4 | 1.47 | 0.38 | 3.79 | 27 |
2.01
|
1.32
|
2.93
| 19 |
2.10
|
1.26
|
3.29
| 11 | 1.37 | 0.68 | 2.46 | 61 |
1.84
|
1.40
|
2.36
|
Immune thrombocytopenic purpura | 8 |
8.60
|
3.67
|
17.03
| 12 |
2.81
|
1.45
|
4.92
| 6 | 2.18 | 0.79 | 4.78 | 2 | 1.23 | 0.12 | 4.54 | 28 |
2.93
|
1.94
|
4.23
|
Localized scleroderma | 0 | 1 | 0.93 | 0.00 | 5.36 | 1 | 0.85 | 0.00 | 4.90 | 6 |
4.32
|
1.55
|
9.46
| 8 | 2.11 | 0.90 | 4.17 | |||
Lupoid hepatitis | 0 | 0 | 0 | 0 | 0 | |||||||||||||||
Multiple sclerosis | 4 | 1.82 | 0.47 | 4.70 | 15 | 1.36 | 0.76 | 2.25 | 9 | 1.09 | 0.49 | 2.08 | 6 | 0.94 | 0.34 | 2.06 | 34 | 1.22 | 0.84 | 1.71 |
Myasthenia gravis | 1 | 1.22 | 0.00 | 6.99 | 8 | 2.09 | 0.89 | 4.14 | 6 | 2.17 | 0.78 | 4.76 | 0 | 15 | 1.62 | 0.90 | 2.68 | |||
Pernicious anemia | 4 | 2.15 | 0.56 | 5.56 | 18 | 1.67 | 0.99 | 2.65 | 13 | 1.52 | 0.81 | 2.61 | 7 | 0.99 | 0.39 | 2.06 | 42 |
1.49
|
1.07
|
2.01
|
Polyarteritis nodosa | 2 | 5.41 | 0.51 | 19.88 | 0 | 0.00 | 0.54 | 2.19 | 3 | 1.91 | 0.36 | 5.66 | 0 | 5 | 1.00 | 0.31 | 2.34 | |||
Polymyalgia rheumatica | 21 |
2.06
|
1.28
|
3.16
| 78 |
1.42
|
1.12
|
1.77
| 65 |
1.67
|
1.29
|
2.13
| 40 |
1.49
|
1.06
|
2.03
| 204 |
1.56
|
1.35
|
1.79
|
Polymyositis/ dermatomyositis | 1 | 2.63 | 0.00 | 15.08 | 3 | 1.95 | 0.37 | 5.77 | 1 | 1.18 | 0.00 | 6.74 | 1 | 2.08 | 0.00 | 11.94 | 6 | 1.85 | 0.66 | 4.04 |
Primary biliary cirrhosis | 1 | 2.08 | 0.00 | 11.94 | 3 | 1.76 | 0.33 | 5.22 | 2 | 2.17 | 0.20 | 7.99 | 0 | 6 | 1.87 | 0.67 | 4.10 | |||
Psoriasis | 9 |
2.88
|
1.31
|
5.50
| 32 |
1.83
|
1.25
|
2.59
| 23 | 1.51 | 0.95 | 2.26 | 21 | 1.32 | 0.81 | 2.02 | 85 |
1.64
|
1.31
|
2.03
|
Reiter´s disease | 0 | 1 | 2.94 | 0.00 | 16.86 | 1 | 2.56 | 0.00 | 14.70 | 0 | 2 | 1.42 | 0.13 | 5.22 | ||||||
Rheumatic fever | 1 | 7.69 | 0.00 | 44.09 | 0 | 0 | 1 | 1.72 | 0.00 | 9.88 | 2 | 1.04 | 0.10 | 3.81 | ||||||
Rheumatoid arthritis | 65 |
3.27
|
2.52
|
4.17
| 191 |
2.03
|
1.76
|
2.34
| 109 |
1.92
|
1.57
|
2.31
| 61 |
1.78
|
1.36
|
2.29
| 426 |
2.08
|
1.89
|
2.29
|
Sarcoidosis | 3 | 2.48 | 0.47 | 7.34 | 12 | 1.87 | 0.96 | 3.28 | 14 |
2.26
|
1.23
|
3.80
| 6 | 0.79 | 0.28 | 1.73 | 35 |
1.64
|
1.14
|
2.28
|
Sjögren´s syndrome | 0 | 3 | 1.35 | 0.25 | 4.00 | 2 | 1.03 | 0.10 | 3.77 | 0 | 5 | 0.81 | 0.26 | 1.90 | ||||||
Systemic lupus erythematosus | 9 |
8.65
|
3.92
|
16.50
| 13 |
2.89
|
1.53
|
4.95
| 4 | 1.17 | 0.31 | 3.03 | 6 | 1.91 | 0.69 | 4.19 | 32 |
2.65
|
1.81
|
3.74
|
Systemic sclerosis | 2 | 3.17 | 0.30 | 11.67 | 5 | 2.67 | 0.84 | 6.29 | 3 | 2.73 | 0.51 | 8.07 | 2 | 3.45 | 0.33 | 12.68 | 12 |
2.87
|
1.48
|
5.03
|
Ulcerative colitis | 7 | 1.45 | 0.57 | 3.00 | 40 |
1.45
|
1.03
|
1.97
| 28 | 1.21 | 0.80 | 1.74 | 33 | 1.44 | 0.99 | 2.02 | 108 |
1.37
|
1.13
|
1.66
|
Wegener´s granulomatosis | 6 |
5.83
|
2.10
|
12.76
| 3 | 0.90 | 0.17 | 2.67 | 2 | 1.08 | 0.10 | 3.95 | 0 | 11 | 1.47 | 0.73 | 2.63 | |||
All | 175 |
2.65
|
2.27
|
3.08
| 602 |
1.83
|
1.69
|
1.98
| 396 |
1.63
|
1.47
|
1.80
| 295 |
1.47
|
1.31
|
1.65
| 1468 |
1.75
|
1.66
|
1.84
|
Hemorrhagic stroke and age and sex
Ischemic stroke
Follow-up interval (years) | ||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
<1 | 1-5 | 5-10 | > = 10 | All | ||||||||||||||||
Immune-mediated diseases | O | SIR | 95% CI | O | SIR | 95% CI | O | SIR | 95% CI | O | SIR | 95% CI | O | SIR | 95% CI | |||||
Addison´s disease | 14 |
2.71
|
1.48
|
4.56
| 28 | 1.17 | 0.78 | 1.69 | 30 |
1.90
|
1.28
|
2.72
| 11 | 0.97 | 0.48 | 1.74 | 83 |
1.48
|
1.18
|
1.83
|
Amyotrophic lateral sclerosis | 7 | 0.53 | 0.21 | 1.10 | 16 | 1.52 | 0.87 | 2.47 | 7 | 1.77 | 0.70 | 3.67 | 2 | 1.15 | 0.11 | 4.23 | 32 | 1.09 | 0.74 | 1.54 |
Ankylosing spondylitis | 8 | 1.62 | 0.69 | 3.21 | 44 |
1.55
|
1.13
|
2.08
| 24 | 0.98 | 0.63 | 1.46 | 35 | 1.08 | 0.75 | 1.50 | 111 |
1.23
|
1.01
|
1.48
|
Autoimmune hemolytic anemia | 4 | 1.45 | 0.38 | 3.75 | 12 | 1.00 | 0.51 | 1.75 | 19 |
2.51
|
1.51
|
3.93
| 5 | 1.23 | 0.39 | 2.90 | 40 |
1.51
|
1.08
|
2.06
|
Behcet´s disease | 1 | 4.00 | 0.00 | 22.93 | 1 | 0.65 | 0.00 | 3.70 | 0 | 1 | 1.43 | 0.00 | 8.19 | 3 | 0.78 | 0.15 | 2.29 | |||
Celiac disease | 9 | 2.17 | 0.99 | 4.14 | 29 | 1.28 | 0.86 | 1.84 | 21 | 1.17 | 0.72 | 1.78 | 26 | 1.47 | 0.96 | 2.15 | 85 |
1.36
|
1.09
|
1.68
|
Chorea minor | 0 | 1 | 2.27 | 0.00 | 13.03 | 0 | 0 | 1 | 1.11 | 0.00 | 6.37 | |||||||||
Crohn disease | 49 |
2.15
|
1.59
|
2.84
| 160 |
1.33
|
1.13
|
1.55
| 103 | 1.11 | 0.91 | 1.35 | 97 | 1.15 | 0.93 | 1.40 | 409 |
1.28
|
1.16
|
1.41
|
Diabetes mellitus type I | 1 | 6.25 | 0.00 | 35.83 | 2 | 0.45 | 0.04 | 1.65 | 5 | 2.75 | 0.87 | 6.46 | 17 |
5.00
|
2.91
|
8.02
| 25 |
2.54
|
1.64
|
3.76
|
Discoid lupus erythematosus | 3 | 4.23 | 0.80 | 12.51 | 3 | 0.99 | 0.19 | 2.92 | 1 | 0.47 | 0.00 | 2.70 | 3 | 1.55 | 0.29 | 4.60 | 10 | 1.28 | 0.61 | 2.37 |
Grave´s disease | 101 |
2.15
|
1.76
|
2.62
| 402 |
1.39
|
1.26
|
1.53
| 348 |
1.36
|
1.22
|
1.51
| 276 |
1.27
|
1.12
|
1.43
| 1127 |
1.39
|
1.31
|
1.48
|
Hashimoto´s thyroiditis | 77 |
2.99
|
2.36
|
3.74
| 211 |
1.73
|
1.50
|
1.98
| 115 |
1.39
|
1.14
|
1.67
| 82 |
1.28
|
1.02
|
1.59
| 485 |
1.64
|
1.50
|
1.80
|
Immune thrombocytopenic purpura | 16 |
2.35
|
1.34
|
3.83
| 55 |
1.77
|
1.33
|
2.30
| 19 | 0.94 | 0.57 | 1.48 | 14 | 1.20 | 0.65 | 2.01 | 104 |
1.49
|
1.22
|
1.81
|
Localized scleroderma | 2 | 1.28 | 0.12 | 4.71 | 13 | 1.25 | 0.66 | 2.14 | 18 |
1.72
|
1.01
|
2.72
| 11 | 1.04 | 0.51 | 1.86 | 44 | 1.33 | 0.97 | 1.79 |
Lupoid hepatitis | 3 | 4.48 | 0.84 | 13.25 | 4 | 1.98 | 0.52 | 5.12 | 0 | 0 | 7 | 2.10 | 0.83 | 4.36 | ||||||
Multiple sclerosis | 40 |
3.05
|
2.18
|
4.15
| 73 | 1.09 | 0.85 | 1.37 | 55 | 1.11 | 0.83 | 1.44 | 35 | 0.95 | 0.66 | 1.32 | 203 |
1.22
|
1.06
|
1.40
|
Myasthenia gravis | 6 | 1.01 | 0.36 | 2.21 | 38 | 1.36 | 0.96 | 1.87 | 23 | 1.20 | 0.76 | 1.80 | 13 | 1.08 | 0.57 | 1.85 | 80 | 1.23 | 0.97 | 1.53 |
Pernicious anemia | 25 |
1.56
|
1.01
|
2.31
| 138 |
1.49
|
1.25
|
1.76
| 89 | 1.23 | 0.99 | 1.52 | 74 |
1.44
|
1.13
|
1.80
| 326 |
1.40
|
1.25
|
1.56
|
Polyarteritis nodosa | 5 | 1.23 | 0.39 | 2.89 | 20 | 1.30 | 0.79 | 2.02 | 11 | 1.05 | 0.52 | 1.88 | 10 | 1.13 | 0.54 | 2.08 | 46 | 1.19 | 0.87 | 1.58 |
Polymyalgia rheumatica | 165 |
1.76
|
1.50
|
2.05
| 761 |
1.50
|
1.39
|
1.61
| 529 |
1.54
|
1.41
|
1.68
| 322 |
1.53
|
1.37
|
1.71
| 1777 |
1.54
|
1.47
|
1.61
|
Polymyositis/ dermatomyositis | 10 |
3.46
|
1.65
|
6.39
| 13 | 1.19 | 0.63 | 2.03 | 6 | 1.07 | 0.38 | 2.34 | 5 | 1.73 | 0.55 | 4.07 | 34 |
1.52
|
1.05
|
2.13
|
Primary biliary cirrhosis | 4 | 1.54 | 0.40 | 3.98 | 11 | 1.45 | 0.72 | 2.60 | 4 | 0.91 | 0.24 | 2.35 | 1 | 2.17 | 0.00 | 12.46 | 20 | 1.33 | 0.81 | 2.05 |
Psoriasis | 44 |
1.92
|
1.39
|
2.58
| 217 |
1.65
|
1.44
|
1.89
| 163 |
1.53
|
1.30
|
1.78
| 144 |
1.41
|
1.19
|
1.66
| 568 |
1.56
|
1.44
|
1.70
|
Reiter´s disease | 0 | 5 | 2.02 | 0.64 | 4.76 | 6 | 2.47 | 0.89 | 5.41 | 2 | 0.56 | 0.05 | 2.07 | 13 | 1.47 | 0.78 | 2.52 | |||
Rheumatic fever | 5 |
3.91
|
1.23
|
9.19
| 10 | 1.66 | 0.79 | 3.06 | 14 |
3.04
|
1.65
|
5.11
| 7 | 1.81 | 0.72 | 3.75 | 36 |
2.28
|
1.59
|
3.16
|
Rheumatoid arthritis | 345 |
2.08
|
1.86
|
2.31
| 1266 |
1.66
|
1.57
|
1.75
| 663 |
1.45
|
1.34
|
1.56
| 326 |
1.30
|
1.16
|
1.45
| 2600 |
1.59
|
1.53
|
1.65
|
Sarcoidosis | 9 | 0.97 | 0.44 | 1.85 | 70 |
1.43
|
1.12
|
1.81
| 51 | 1.12 | 0.83 | 1.47 | 56 | 1.08 | 0.81 | 1.40 | 186 |
1.19
|
1.03
|
1.38
|
Sjögren´s syndrome | 10 |
2.57
|
1.22
|
4.75
| 28 | 1.38 | 0.92 | 1.99 | 15 | 0.96 | 0.54 | 1.59 | 15 | 1.26 | 0.70 | 2.08 | 68 |
1.31
|
1.02
|
1.67
|
Systemic lupus erythematosus | 19 |
2.21
|
1.33
|
3.46
| 88 |
2.33
|
1.87
|
2.87
| 54 |
1.92
|
1.44
|
2.51
| 30 | 1.26 | 0.85 | 1.80 | 191 |
1.94
|
1.68
|
2.24
|
Systemic sclerosis | 11 | 1.90 | 0.94 | 3.41 | 28 | 1.22 | 0.81 | 1.77 | 11 | 1.19 | 0.59 | 2.14 | 2 | 0.39 | 0.04 | 1.43 | 52 | 1.21 | 0.90 | 1.58 |
Ulcerative colitis | 71 |
2.15
|
1.68
|
2.71
| 231 |
1.27
|
1.11
|
1.45
| 162 | 1.09 | 0.92 | 1.27 | 146 | 1.05 | 0.89 | 1.24 | 610 |
1.21
|
1.12
|
1.31
|
Wegener´s granulomatosis | 11 | 1.66 | 0.82 | 2.98 | 12 | 0.47 | 0.24 | 0.83 | 26 |
1.54
|
1.00
|
2.25
| 12 | 1.69 | 0.87 | 2.96 | 61 | 1.09 | 0.83 | 1.40 |
All | 1075 |
2.02
|
1.90
|
2.14
| 3990 |
1.50
|
1.46
|
1.55
| 2592 |
1.38
|
1.33
|
1.43
| 1780 |
1.29
|
1.23
|
1.35
| 9437 |
1.46
|
1.43
|
1.49
|